Journal of Clinical Medicine,
Journal Year:
2019,
Volume and Issue:
8(4), P. 444 - 444
Published: April 2, 2019
Atopic
dermatitis
(AD)
is
a
long-standing
inflammatory
skin
disease
that
highly
prevalent
worldwide.
Multiple
factors
contribute
to
AD,
with
genetics
as
well
the
environment
affecting
development.
Although
AD
shows
signs
of
barrier
defect
and
immunological
deviation,
mechanism
underlying
not
understood,
treatment
often
very
difficult.
There
substantial
data
patients
have
disturbed
microbial
composition
lack
diversity
in
their
gut
compared
controls,
which
contributes
onset
atopic
march.
It
clear
whether
change
an
outcome
or
cause
dysfunction
inflammation.
However,
cross-talk
between
commensals
immune
system
now
noticed,
alteration
believed
affect
maturation
innate
adaptive
immunity
during
early
life.
The
novel
concept
modifying
microbiome
by
applying
moisturizers
contain
nonpathogenic
biomass
probiotic
supplementation
years
may
be
preventive
therapeutic
option
high
risk
groups,
but
currently
lacks
evidence.
This
review
discusses
nature
flora
possible
mechanisms
skin–gut
interaction,
implications
correction
AD.
Science,
Journal Year:
2022,
Volume and Issue:
376(6596), P. 940 - 945
Published: May 26, 2022
Human
skin
forms
a
protective
barrier
against
the
external
environment
and
is
our
first
line
of
defense
toxic,
solar,
pathogenic
insults.
Our
also
defines
outward
appearance,
protects
internal
tissues
organs,
acts
as
sensory
interface,
prevents
dehydration.
Crucial
to
skin's
function
colonizing
microbiota,
which
provides
protection
pathogens,
tunes
immune
responses,
fortifies
epithelium.
Here
we
highlight
recent
advances
in
understanding
how
microbiota
mediates
multiple
facets
function.
We
discuss
insights
into
pathological
host-microbiota
interactions
implications
for
disorders
distant
organs.
Finally,
examine
microbiota-based
mechanisms
can
be
targeted
prevent
or
manage
impaired
wound
healing.
Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: Oct. 16, 2019
Abstract
Despite
recent
advances
in
understanding
microbial
diversity
skin
homeostasis,
the
relevance
of
dysbiosis
inflammatory
disease
is
poorly
understood.
Here
we
perform
a
comparative
analysis
communities
coupled
to
global
patterns
cutaneous
gene
expression
patients
with
atopic
dermatitis
or
psoriasis.
The
microbiota
analysed
by
16S
amplicon
whole
genome
sequencing
and
transcriptome
microarrays,
followed
integration
data
layers.
We
find
that
psoriasis
can
be
classified
distinct
microbes,
which
differ
from
healthy
volunteers
microbiome
composition.
Atopic
dominated
single
microbe
(
Staphylococcus
aureus
),
associated
relevant
host
transcriptomic
signature
enriched
for
barrier
function,
tryptophan
metabolism
immune
activation.
In
contrast,
characterized
co-occurring
microbes
weak
associations
related
expression.
Our
work
provides
basis
biomarker
discovery
targeted
therapies
dysbiosis.
Allergy Asthma and Immunology Research,
Journal Year:
2018,
Volume and Issue:
10(3), P. 207 - 207
Published: Jan. 1, 2018
The
epidermis
contains
epithelial
cells,
immune
and
microbes
which
provides
a
physical
functional
barrier
to
the
protection
of
human
skin.
It
plays
critical
roles
in
preventing
environmental
allergen
penetration
into
body
responsing
microbial
pathogens.
Atopic
dermatitis
(AD)
is
most
common,
complex
chronic
inflammatory
skin
disease.
Skin
dysfunction
initial
step
development
AD.
Multiple
factors,
including
dysregulation,
filaggrin
mutations,
deficiency
antimicrobial
peptides,
dysbiosis
contribute
defects.
In
phase
AD,
treatment
with
moisturizers
improves
function
prevents
With
progression
effective
topical
systemic
therapies
are
needed
reduce
pathway
activation
general
inflammation.
Targeted
microbiome
therapy
also
being
developed
correct
associated
Improved
identification
characterization
AD
phenotypes
endotypes
required
optimize
precision
medicine
approach
Microbiome,
Journal Year:
2018,
Volume and Issue:
6(1)
Published: Sept. 5, 2018
Psoriasis
impacts
1-3%
of
the
world's
population
and
is
characterized
by
hyper-proliferation
keratinocytes
increased
inflammation.
At
molecular
level,
psoriasis
commonly
driven
a
Th17
response,
which
serves
as
major
therapeutic
target.
Microbiome
perturbations
have
been
associated
with
several
immune-mediated
diseases
such
atopic
dermatitis,
asthma,
multiple
sclerosis.
Although
few
studies
investigated
association
between
skin
microbiome
psoriasis,
conflicting
results
reported
plausibly
due
to
lack
standardized
sampling
profiling
protocols,
or
inherent
microbial
variability
across
human
subjects
underpowered
studies.
To
better
understand
link
cutaneous
microbiota
we
conducted
an
analysis
bacterial
communities
28
patients
26
healthy
subjects,
sampled
at
six
body
sites
using
protocol
higher
sequencing
depth
compared
previous
Mouse
were
employed
examine
dermal
microbial-immune
interactions
species
identified
from
our
study.Skin
based
on
16S
rRNA
V1-V3
variable
region
revealed
significant
differences
psoriasis-associated
microbiota.
Comparing
overall
community
structures,
displayed
diversity
more
heterogeneity
communities.
Specific
signatures
psoriatic
lesional,
non-lesional,
skin.
Specifically,
relative
enrichment
Staphylococcus
aureus
was
strongly
both
lesional
non-lesional
In
contrast,
epidermidis
Propionibacterium
acnes
underrepresented
in
lesions
skin,
especially
arm,
gluteal
fold,
trunk.
Employing
mouse
model
further
study
impact
Staphylcoccus
T
cell
differentiation,
found
that
newborn
mice
colonized
demonstrated
strong
polarization,
whereas
un-colonized
controls
showed
no
response.Our
suggest
substantially
different
those
The
has
reduced
stability
microbiome.
loss
decrease
immunoregulatory
bacteria
may
lead
colonization
pathogens
aureus,
could
exacerbate
inflammation
along
axis.
