Life Science Alliance,
Journal Year:
2022,
Volume and Issue:
5(8), P. e202101338 - e202101338
Published: May 5, 2022
AAV-mediated
optogenetic
neural
stimulation
has
become
a
clinical
approach
for
restoring
function
in
sensory
disorders
and
feasibility
hearing
restoration
been
indicated
rodents.
Nonetheless,
long-term
stability
safety
of
channelrhodopsin
(ChR)
expression
spiral
ganglion
neurons
(SGNs)
remained
to
be
addressed.
Here,
we
used
longitudinal
studies
on
mice
subjected
early
postnatal
administration
AAV2/6
carrying
fast
gating
ChR
f-Chrimson
under
the
control
human
synapsin
promoter
unilaterally
cochlea.
SGNs
both
ears
brain
was
probed
animals
aged
1
mo
2
yr.
observed
at
all
ages
indicating
longevity
ChR-expression.
SGN
numbers
AAV-injected
cochleae
declined
with
age
faster
than
controls.
Investigations
were
extended
which
viral
transduction
across
organ
varying
degrees
irrespective
without
observing
spread-related
pathologies.
No
DNA
or
virus-related
histopathological
findings
visceral
organs
encountered.
In
summary,
our
study
demonstrates
life-long
(24
mice)
upon
single
AAV-dosing
JASA Express Letters,
Journal Year:
2022,
Volume and Issue:
2(7)
Published: July 1, 2022
Cochlear
implants
have
been
the
most
successful
neural
prosthesis,
with
one
million
users
globally.
Researchers
used
source-filter
model
and
speech
vocoder
to
design
modern
multi-channel
implants,
allowing
implantees
achieve
70%–80%
correct
sentence
recognition
in
quiet,
on
average.
also
cochlear
implant
help
understand
basic
mechanisms
underlying
loudness,
pitch,
cortical
plasticity.
While
front-end
processing
advances
improved
noise,
unilateral
quiet
has
plateaued
since
early
1990s.
This
lack
of
progress
calls
for
action
re-designing
stimulating
interface
collaboration
general
neurotechnology
community.
Advanced Optical Materials,
Journal Year:
2021,
Volume and Issue:
9(14)
Published: May 17, 2021
Abstract
As
solid‐state
light
sources
based
on
amorphous
organic
semiconductors,
light‐emitting
diodes
(OLEDs)
are
widely
used
in
modern
smartphone
displays
and
TVs.
Due
to
the
dramatic
improvements
stability,
efficiency,
brightness
achieved
over
last
three
decades,
OLEDs
have
also
become
attractive
for
compact
“imperceptible”
biomedical
devices
that
use
probe,
image,
manipulate,
or
treat
biological
matter.
The
inherent
mechanical
flexibility
of
their
compatibility
with
a
wide
range
substrates
geometries
particular
benefit
this
context.
Here,
recent
progress
development
applications
is
reviewed.
specific
requirements
poses
described
compared
current
state
art,
terms
brightness,
patterning,
encapsulation
OLEDs.
Examples
from
several
main
areas
then
discussed
some
detail:
on‐chip
sensing
integration
microfluidics,
wearable
optical
monitoring,
therapeutic
devices,
emerging
neuroscience
targeted
photostimulation
via
optogenetics.
review
closes
brief
outlook
future
avenues
scale
manufacturing
OLED‐based
use.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Feb. 11, 2022
Abstract
Optogenetic
methods
provide
efficient
cell-specific
modulations,
and
the
ability
of
simultaneous
neural
activation
inhibition
in
same
brain
region
freely
moving
animals
is
highly
desirable.
Here
we
report
bidirectional
neuronal
activity
manipulation
accomplished
by
a
wireless,
dual-color
optogenetic
probe
synergy
with
co-expression
two
spectrally
distinct
opsins
(ChrimsonR
stGtACR2)
rodent
model.
The
flexible
comprises
vertically
assembled,
thin-film
microscale
light-emitting
diodes
lateral
dimension
125
×
180
µm
2
,
showing
colocalized
red
blue
emissions
enabling
chronic
vivo
operations
desirable
biocompatibilities.
Red
or
irradiations
deterministically
evoke
silence
neurons
co-expressing
opsins.
interferes
dopaminergic
ventral
tegmental
area
mice,
increasing
decreasing
dopamine
levels.
Such
regulations
further
generate
rewarding
aversive
behaviors
interrogate
social
interactions
among
multiple
mice.
These
technologies
create
numerous
opportunities
implications
for
research.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(42)
Published: Sept. 19, 2023
Abstract
Optogenetic
modulation
of
brain
neural
activity
that
combines
optical
and
electrical
modes
in
a
unitary
system
has
recently
gained
robust
momentum.
Controlling
illumination
spatial
coverage,
designing
light‐activated
modulators,
developing
wireless
light
delivery
data
transmission
are
crucial
for
maximizing
the
use
neuromodulation.
To
this
end,
biocompatible
electrodes
with
enhanced
optoelectrical
performance,
device
integration
multiplexed
addressing,
transmission,
multimodal
operation
soft
systems
have
been
developed.
This
review
provides
an
outlook
uniformly
illuminating
large
areas
while
spatiotemporally
imaging
responses
upon
stimulation
little
artifacts.
Representative
concepts
important
breakthroughs,
such
as
head‐mounted
illumination,
multiple
implanted
fibers,
micro‐light‐delivery
devices,
discussed.
Examples
techniques
incorporate
electrophysiological
monitoring
presented.
Challenges
perspectives
posed
further
research
efforts
toward
high‐density
interface
modulation,
potential
nonpharmacological
neurological
disease
treatments
stimulation.
Annual Review of Neuroscience,
Journal Year:
2024,
Volume and Issue:
47(1), P. 103 - 121
Published: April 10, 2024
The
cochlear
implant
(CI)
is
considered
the
most
successful
neuroprosthesis
as
it
enables
speech
comprehension
in
majority
of
million
otherwise
deaf
patients.
In
hearing
by
electrical
stimulation
auditory
nerve,
broad
spread
current
from
each
electrode
acts
a
bottleneck
that
limits
transfer
sound
frequency
information.
Hence,
there
remains
major
unmet
medical
need
for
improving
quality
with
CIs.
Recently,
optogenetic
cochlea
has
been
suggested
an
alternative
approach
restoration.
Cochlear
optogenetics
promises
to
more
information,
hence
hearing,
light
can
conveniently
be
confined
space
activate
nerve
within
smaller
tonotopic
ranges.
this
review,
we
discuss
latest
experimental
and
technological
developments
restoration
outline
remaining
challenges
en
route
clinical
translation.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(10)
Published: March 6, 2024
Compact
wireless
light
sources
are
a
fundamental
building
block
for
applications
ranging
from
displays
to
optical
implants.
However,
their
realization
remains
challenging
because
of
constraints
in
miniaturization
and
the
integration
power
harvesting
light-emission
technologies.
Here,
we
introduce
strategy
compact
wirelessly
powered
light-source
that
consists
magnetoelectric
transducer
serving
as
source
substrate
an
antiparallel
pair
custom-designed
organic
light-emitting
diodes.
The
devices
operate
at
low-frequency
ac
magnetic
fields
(~100
kHz),
which
has
added
benefit
allowing
operation
multiple
centimeters
deep
inside
watery
environments.
By
tuning
device
resonance
frequency,
it
is
possible
separately
address
devices,
e.g.,
produce
distinct
colors,
individual
display
pixels,
or
clustered
operation.
simultaneously
offering
small
size,
addressing,
compatibility
with
environments,
our
pave
way
multitude
displays,
tissue
treatment,
sensing,
imaging.
EMBO Molecular Medicine,
Journal Year:
2021,
Volume and Issue:
13(6)
Published: May 7, 2021
Optogenetic
stimulation
of
spiral
ganglion
neurons
(SGNs)
in
the
ear
provides
a
future
alternative
to
electrical
used
current
cochlear
implants.
Here,
we
employed
fast
and
very
variants
red-light-activated
channelrhodopsin
(ChR)
Chrimson
(f-Chrimson
vf-Chrimson)
study
their
utility
for
optogenetic
SGNs
mice.
The
light
requirements
were
higher
vf-Chrimson
than
f-Chrimson,
even
when
optimizing
membrane
expression
by
adding
potassium
channel
trafficking
sequences.
time
intensity
coding
single
putative
compared
with
acoustic
clicks.
enabled
fire
at
near-physiological
rates
good
temporal
precision
up
250
Hz
stimulation.
dynamic
range
SGN
spike
rate
upon
was
narrower
clicks
but
larger
reported
timing,
on
other
hand,
more
comparable
In
conclusion,
f-Chrimson
are
promising
candidates
auditory
research
