Post-acute COVID-19 syndrome

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(4), P. 601 - 615

Published: March 22, 2021

Language: Английский

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Cross-tissue organization of the fibroblast lineage

Nature, Journal Year: 2021, Volume and Issue: 593(7860), P. 575 - 579

Published: May 12, 2021

Language: Английский

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Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis

Annual Review of Pathology Mechanisms of Disease, Journal Year: 2021, Volume and Issue: 17(1), P. 515 - 546

Published: Nov. 23, 2021

The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay cell types and signaling pathways. Recurrent alveolar epithelial (AEC) injury may occur in the context predisposing factors (e.g., genetic, environmental, epigenetic, immunologic, gerontologic), leading to metabolic dysfunction, senescence, aberrant activation, dysregulated repair. interacts with mesenchymal, immune, endothelial cells via multiple mechanisms trigger fibroblast myofibroblast activation. Recent single-cell RNA sequencing studies IPF lungs support model. These have uncovered novel type AEC characteristics an basal cell, which disrupt normal repair propagate profibrotic phenotype. Here, we review bioinformatics tools as strategies discover pathways disease, cell-specific mechanisms, cell-cell interactions that niche.

Language: Английский

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SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

Cell, Journal Year: 2021, Volume and Issue: 184(26), P. 6243 - 6261.e27

Published: Nov. 27, 2021

Language: Английский

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An integrated cell atlas of the lung in health and disease

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(6), P. 1563 - 1577

Published: June 1, 2023

Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations individual the variability present in population. Here we integrated Human Lung Cell Atlas (HLCA), combining 49 respiratory system into single atlas spanning over 2.4 million cells from 486 individuals. The HLCA presents consensus re-annotation with matching marker genes, including annotations rare previously undescribed types. Leveraging diversity individuals HLCA, identify gene modules that are associated demographic covariates such as age, sex body mass index, well changing expression along proximal-to-distal axis bronchial tree. Mapping new data to enables rapid annotation interpretation. Using reference for study disease, shared states across multiple lung diseases, SPP1

Language: Английский

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Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: June 30, 2021

More than one year since its emergence, corona virus disease 2019 (COVID-19) is still looming large with a paucity of treatment options. To add to this burden, sizeable subset patients who have recovered from acute COVID-19 infection reported lingering symptoms, leading significant disability and impairment their daily life activities. These are considered suffer what has been termed as “chronic” or “long” form post-acute sequelae COVID-19, experiencing syndrome long-haulers. Despite recovery infection, the persistence atypical chronic including extreme fatigue, shortness breath, joint pains, brain fogs, anxiety depression, that could last for months implies an underlying pathology persist beyond presentation disease. As opposed direct effects itself, immune response severe respiratory coronavirus 2 (SARS-CoV-2) believed be largely responsible appearance these lasting possibly through facilitating ongoing inflammatory process. In review, we hypothesize potential immunological mechanisms persistent prolonged effects, describe multi-organ long-term manifestations COVID-19.

Language: Английский

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Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries

The Lancet Respiratory Medicine, Journal Year: 2021, Volume and Issue: 9(5), P. 487 - 497

Published: April 1, 2021

Language: Английский

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Pulmonary fibrosis secondary to COVID-19: a narrative review

Expert Review of Respiratory Medicine, Journal Year: 2021, Volume and Issue: 15(6), P. 791 - 803

Published: April 27, 2021

Introduction: Coronavirus disease 2019 (COVID-19) is still increasing worldwide, and as a result, the number of patients with pulmonary fibrosis secondary to COVID-19 will expand over time. Risk factors, histopathological characterization, pathophysiology, prevalence, management post-COVID-19 are poorly understood, few studies have addressed these issues.Areas covered:This article reviews current evidence regarding fibrosis, an emphasis on potential risk histopathology, functional tomographic features, therapeutic modalities. A search issue was performed in MEDLINE, Embase, SciELO databases Cochrane library between 1 December 2019, 25 January 2021. Studies were reviewed relevant topics incorporated into this narrative review. Expert opinion: Pulmonary sequelae may occur COVID-19, which needs be included etiology differential diagnosis fibrosis. Therefore, serial clinical, tomographic, screening for recommended after mainly involvement acute phase disease. Further necessary determine markers, appropriate

Language: Английский

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From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?

Translational research, Journal Year: 2021, Volume and Issue: 241, P. 13 - 24

Published: Sept. 20, 2021

While the coronavirus disease 19 (COVID-19) pandemic has transformed medical and scientific communites since it was first reported in late 2019, we are only beginning to understand chronic health burdens associated with this disease. Although COVID-19 is a multi-systemic disease, lungs primary source of infection injury, resulting pneumonia and, severe cases, acute respiratory distress syndrome (ARDS). Given that pulmonary fibrosis well-recognized sequela ARDS, many have questioned whether survivors will face long-term consequences. This review aimed at integrating our understanding pathophysiologic mechanisms underlying fibroproliferative ARDS current knowledge consequences

Language: Английский

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SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

Science Translational Medicine, Journal Year: 2022, Volume and Issue: 14(664)

Published: July 7, 2022

A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop post-acute sequelae severe acute respiratory syndrome 2 (SARS-CoV-2) (PASC), but the mechanistic basis PASC-associated lung abnormalities suffers a lack longitudinal tissue samples. The mouse-adapted SARS-CoV-2 strain MA10 produces an distress in mice similar to humans. To investigate PASC pathogenesis, studies MA10-infected were extended clinical recovery phases. At 15 120 days after virus clearance, pulmonary histologic findings included subpleural lesions composed collagen, proliferative fibroblasts, and chronic inflammation, including tertiary lymphoid structures. Longitudinal spatial transcriptional profiling identified global reparative fibrotic pathways dysregulated diseased regions, human COVID-19. Populations alveolar intermediate cells, coupled with focal up-regulation profibrotic markers, persistently regions. Early intervention antiviral EIDD-2801 reduced disease, early antifibrotic agent (nintedanib) modified severity. This murine model provides opportunities identify associated persistent test countermeasures ameliorate PASC.

Language: Английский

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