MedComm,
Journal Year:
2023,
Volume and Issue:
4(3)
Published: June 1, 2023
Gene
therapy,
a
medical
approach
that
involves
the
correction
or
replacement
of
defective
and
abnormal
genes,
plays
an
essential
role
in
treatment
complex
refractory
diseases,
such
as
hereditary
cancer,
rheumatic
immune
diseases.
Nucleic
acids
alone
do
not
easily
enter
target
cells
due
to
their
easy
degradation
vivo
structure
cell
membranes.
The
introduction
genes
into
biological
is
often
dependent
on
gene
delivery
vectors,
adenoviral
which
are
commonly
used
therapy.
However,
traditional
viral
vectors
have
strong
immunogenicity
while
also
presenting
potential
infection
risk.
Recently,
biomaterials
attracted
attention
for
use
efficient
vehicles,
because
they
can
avoid
drawbacks
associated
with
vectors.
Biomaterials
improve
stability
nucleic
efficiency
intracellular
delivery.
This
review
focused
biomaterial-based
systems
therapy
disease
treatment.
Herein,
we
recent
developments
modalities
Additionally,
discuss
acid
strategies,
focus
systems.
Furthermore,
current
applications
summarized.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(51)
Published: May 17, 2023
Abstract
Messenger
RNA
(mRNA)
has
received
great
attention
in
the
prevention
and
treatment
of
various
diseases
due
to
success
coronavirus
disease
2019
(COVID‐19)
mRNA
vaccines
(Comirnaty
Spikevax).
To
meet
therapeutic
purpose,
it
is
required
that
must
enter
target
cells
express
sufficient
proteins.
Therefore,
development
effective
delivery
systems
necessary
crucial.
Lipid
nanoparticle
(LNP)
represents
a
remarkable
vehicle
indeed
accelerated
applications
humans,
as
several
mRNA‐based
therapies
have
already
been
approved
or
are
clinical
trials.
In
this
review,
focus
on
mRNA‐LNP‐mediated
anticancer
therapy.
It
summarizes
main
strategies
mRNA‐LNP
formulations,
discusses
representative
approaches
cancer,
points
out
current
challenges
possible
future
directions
research
field.
hoped
these
delivered
messages
can
help
further
improve
application
technology
cancer
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7493 - 7493
Published: April 19, 2023
The
tumor
microenvironment
(TME)
is
a
critical
regulator
of
growth,
progression,
and
metastasis.
Among
the
innate
immune
cells
recruited
to
site,
macrophages
are
most
abundant
cell
population
present
at
all
stages
progression.
They
undergo
M1/M2
polarization
in
response
signals
derived
from
TME.
M1
suppress
while
their
M2
counterparts
exert
pro-tumoral
effects
by
promoting
angiogenesis,
metastasis,
resistance
current
therapies.
Several
subsets
phenotype
have
been
observed,
often
denoted
as
M2a,
M2b,
M2c,
M2d.
These
induced
different
stimuli
differ
phenotypes
well
functions.
In
this
review,
we
discuss
key
features
each
subset,
implications
cancers,
highlight
strategies
that
being
developed
harness
TAMs
for
cancer
treatment.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(23), P. 23223 - 23261
Published: Dec. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 8, 2024
Abstract
Glioblastoma
(GBM),
the
predominant
and
primary
malignant
intracranial
tumor,
poses
a
formidable
challenge
due
to
its
immunosuppressive
microenvironment,
thereby
confounding
conventional
therapeutic
interventions.
Despite
established
treatment
regimen
comprising
surgical
intervention,
radiotherapy,
temozolomide
administration,
exploration
of
emerging
modalities
such
as
immunotherapy
integration
medicine
engineering
technology
therapy,
efficacy
these
approaches
remains
constrained,
resulting
in
suboptimal
prognostic
outcomes.
In
recent
years,
intensive
scrutiny
inhibitory
milieu
within
GBM
has
underscored
significance
cellular
constituents
microenvironment
their
interactions
with
cells
neurons.
Novel
immune
targeted
therapy
strategies
have
emerged,
offering
promising
avenues
for
advancing
treatment.
One
pivotal
mechanism
orchestrating
immunosuppression
involves
aggregation
myeloid-derived
suppressor
(MDSCs),
glioma-associated
macrophage/microglia
(GAM),
regulatory
T
(Tregs).
Among
these,
MDSCs,
though
constituting
minority
(4–8%)
CD45
+
GBM,
play
central
component
fostering
evasion
propelling
tumor
progression,
angiogenesis,
invasion,
metastasis.
MDSCs
deploy
intricate
mechanisms
that
adapt
dynamic
(TME).
Understanding
interplay
between
provides
compelling
basis
This
review
seeks
elucidate
inherent
explore
existing
targets,
consolidate
insights
into
MDSC
induction
contribution
immunosuppression.
Additionally,
comprehensively
surveys
ongoing
clinical
trials
potential
strategies,
envisioning
future
where
targeting
could
reshape
landscape
GBM.
Through
synergistic
other
modalities,
this
approach
can
establish
multidisciplinary,
multi-target
paradigm,
ultimately
improving
prognosis
quality
life
patients
Exploration,
Journal Year:
2023,
Volume and Issue:
3(4)
Published: July 2, 2023
Abstract
Adoptive
cell
therapy
(ACT)
is
a
rapidly
growing
anti‐cancer
strategy
that
has
shown
promise
in
treating
various
cancer
types.
The
concept
of
ACT
involves
activating
patients’
own
immune
cells
ex
vivo
and
then
transferring
them
back
to
the
patients
recognize
eliminate
cells.
Currently,
commonly
used
includes
tumor‐infiltrating
lymphocytes
(TILs),
genetically
engineered
cells,
dendritic
(DCs)
vaccines.
With
advancement
culture
genetic
engineering
techniques,
been
clinics
treat
malignant
hematological
diseases
many
new
ACT‐based
regimens
are
different
stages
clinical
trials.
Here,
representative
approaches
introduced
opportunities
challenges
for
translation
discussed.
Biomarker Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Nov. 28, 2023
Abstract
Today,
adoptive
cell
therapy
has
many
successes
in
cancer
therapy,
and
this
subject
is
brilliant
using
chimeric
antigen
receptor
T
cells.
The
CAR
with
its
FDA-approved
drugs,
could
treat
several
types
of
hematological
malignancies
thus
be
very
attractive
for
treating
solid
cancer.
Unfortunately,
the
cannot
functional
cancers
due
to
unique
features.
This
treatment
method
harmful
adverse
effects
that
limit
their
applications,
so
novel
treatments
must
use
new
cells
like
NK
cells,
NKT
macrophage
Among
these
innate
features,
are
more
tumor
seem
a
better
candidate
prior
methods.
have
vital
roles
microenvironment
and,
direct
effect,
can
eliminate
efficiently.
In
addition,
being
part
immune
system,
attended
sites.
With
high
infiltration,
modulations
effective.
review
investigates
last
achievements
CAR-macrophage
future
immunotherapy
method.
BMEMat,
Journal Year:
2023,
Volume and Issue:
1(3)
Published: July 19, 2023
Abstract
Cell
therapy
has
revolutionized
the
treatment
of
various
diseases,
such
as
cancers,
genetic
disorders,
and
autoimmune
diseases.
Currently,
most
cell
products
rely
on
ex
vivo
engineering,
which
requires
sophisticated
manufacturing
processes
poses
safety
concerns.
The
implementation
in
situ
holds
potential
to
overcome
current
limitations
provides
a
broad
range
applications
clinical
feasibility
future.
A
variety
biomaterials
have
been
developed
improve
function
target
delivery
specific
types
due
their
excellent
biocompatibility,
tunable
properties,
other
functionalities,
provide
reliable
method
achieve
modulation
reprogramming.
In
this
article,
we
summarize
recent
advances
for
including
T
cells,
macrophages,
dendritic
stem
cells
reprogramming
leveraging
lipid
nanoparticles,
polymers,
inorganic
materials,
biomaterials.
Finally,
discuss
challenges
future
perspectives
therapy.
