Exploring the Landscape of Fermentation: Products, Processes, and Outlook DOI
Igor Carvalho Fontes Sampaio,

Pedro Francisco,

Isabela Viana Lopes de Moura

et al.

Engineering materials, Journal Year: 2024, Volume and Issue: unknown, P. 433 - 454

Published: Jan. 1, 2024

Language: Английский

Synthetic biology meets Aspergillus: engineering strategies for next-generation organic acid production DOI
Yang Wu,

Qian-Hui Xu,

Zilei Chen

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 13, 2025

Language: Английский

Citations

0
Progress on production of malic acid and succinic acid by industrially-important engineered microorganisms DOI
Na Wu, Wenxin Wang, Jian-Guo Zhu

et al.

Journal of Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Improving Organic Acid Secretion of Aspergillus niger by Overexpression C4-Dicarboxylic Acid Transporters DOI Creative Commons
Yiyang Tan, Shutong Liu,

Sheng Wu

et al.

Fermentation, Journal Year: 2025, Volume and Issue: 11(3), P. 156 - 156

Published: March 20, 2025

C4-dicarboxylic acids are essential organic compounds characterized by a four-carbon structure and two carboxyl groups. Their export from cells is mediated specialized transporter proteins known as acid transporters (DCTs). The objective of this study was to investigate the specificity six DCTs (DCT1-5 C4t318) Aspergillus niger or oryzae, focusing on their role in different production strategies for acids. results indicate that compared WT strain, overexpressing dct2 dct3 A. CGMCC NO. 40550 specifically enhances succinic acid, increasing its yield 5.69 g/L 6.28 g/L, L-malic 11.02 12.11 g/L. Additionally, dct5 appears be involved transport both (6.19 g/L) (16.33 g/L). total yields T-D3-7, which lacks oxaloacetate hydrolase gene, were improved 27.75 25.19 T-D3-26, due blocking branch metabolism. Furthermore, heterologous expression oryzae C4T318 increased approximately 22.5%. best observed when strains T-D3-7 T-D5-16 scaled up 30 L bioreactor 84 h. reached 14.51 70.79 41.59 81.08 respectively. Moreover, purity produced 71%. This work further clarifies provides valuable insights optimizing production.

Language: Английский

Citations

0
Integrated Metagenomics and Metabolomics Analysis Illustrates the Systemic Impact of the Calcium Ions-Induced Microbial Migration on Organic Acid Metabolism in Chunjang DOI
Dan Yang, Siqi Li,

Lu Kong

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring the Landscape of Fermentation: Products, Processes, and Outlook DOI
Igor Carvalho Fontes Sampaio,

Pedro Francisco,

Isabela Viana Lopes de Moura

et al.

Engineering materials, Journal Year: 2024, Volume and Issue: unknown, P. 433 - 454

Published: Jan. 1, 2024

Language: Английский

Citations

0