Aspergillus fumigatus and Aspergillosis in 2019

Clinical Microbiology Reviews, Journal Year: 2019, Volume and Issue: 33(1)

Published: Nov. 12, 2019

Aspergillus fumigatus is a saprotrophic fungus; its primary habitat the soil. In ecological niche, fungus has learned how to adapt and proliferate in hostile environments. This capacity helped resist survive against human host defenses and, further, be responsible for one of most devastating lung infections terms morbidity mortality.

Language: Английский

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Light sensing and responses in fungi

Nature Reviews Microbiology, Journal Year: 2018, Volume and Issue: 17(1), P. 25 - 36

Published: Oct. 30, 2018

Language: Английский

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Molecular and physiological effects of environmental UV radiation on fungal conidia

Current Genetics, Journal Year: 2015, Volume and Issue: 61(3), P. 405 - 425

Published: April 1, 2015

Language: Английский

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Stress tolerance and virulence of insect-pathogenic fungi are determined by environmental conditions during conidial formation

Current Genetics, Journal Year: 2015, Volume and Issue: 61(3), P. 383 - 404

Published: March 19, 2015

Language: Английский

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Assessing the Effects of Light on Differentiation and Virulence of the Plant Pathogen Botrytis cinerea: Characterization of the White Collar Complex

PLoS ONE, Journal Year: 2013, Volume and Issue: 8(12), P. e84223 - e84223

Published: Dec. 31, 2013

Organisms are exposed to a tough environment, where acute daily challenges, like light, can strongly affect several aspects of an individual's physiology, including pathogenesis. While fungal models have been widely employed understand the physiological and molecular events associated with light perception, various other agricultural-relevant fungi still remain, in terms their responsiveness dark. The fungus Botrytis cinerea is aggressive pathogen able cause disease on wide range plant species. Natural B. isolates exhibit high degree diversity predominant mode reproduction. Thus, majority naturally occurring strains known reproduce asexually via conidia sclerotia, sexually apothecia. Studies from 1970′s reported specific developmental responses treatments near-UV, blue, red far-red light. To unravel signaling machinery triggering development – possibly also connected virulence we initiated functional characterization transcription factor/photoreceptor BcWCL1 its partner BcWCL2, that form White Collar Complex (WCC) cinerea. Using mutants either abolished or exhibiting enhanced WCC (overexpression both bcwcl1 bcwcl2), demonstrate integral part mentioned by mediating transcriptional white inhibition conidiation response this stimulus. Furthermore, required for coping excessive oxidative stress achieve full virulence. Although absence bcwcl1, expression some genes induced distinct pattern oscillations enhanced, revealing complex underlying photobiology. Though overlaps well-studied systems exist, light-associated appears more than those Neurospora crassa Aspergillus nidulans.

Language: Английский

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The Transcription Factor BcLTF1 Regulates Virulence and Light Responses in the Necrotrophic Plant Pathogen Botrytis cinerea

PLoS Genetics, Journal Year: 2014, Volume and Issue: 10(1), P. e1004040 - e1004040

Published: Jan. 9, 2014

Botrytis cinerea is the causal agent of gray mold diseases in a range dicotyledonous plant species. The fungus can reproduce asexually by forming macroconidia for dispersal and sclerotia survival; latter also participate sexual reproduction bearing apothecia after fertilization microconidia. Light induces differentiation conidia apothecia, while are exclusively formed absence light. relevance light virulence not obvious, but infections observed under natural illumination as well constant darkness. By random mutagenesis approach, we identified novel virulence-related gene encoding GATA transcription factor (BcLTF1 light-responsive TF1) with characterized homologues Aspergillus nidulans (NsdD) Neurospora crassa (SUB-1). deletion over-expression bcltf1, confirmed predicted role virulence, discovered furthermore its functions regulation light-dependent differentiation, equilibrium between production scavenging reactive oxygen species (ROS), secondary metabolism. Microarray analyses revealed 293 genes, that expression levels majority these genes (66%) modulated BcLTF1. In addition, bcltf1 affects 1,539 irrespective conditions, including overexpression known so far uncharacterized metabolism-related genes. Increased alternative respiration enzymes, such oxidase (AOX), suggest mitochondrial dysfunction bcltf1. hypersensitivity Δbctlf1 mutants to exogenously applied oxidative stress - even restoration growth rates continuous antioxidants, indicate BcLTF1 required cope caused either exposure or arising during host infection.

Language: Английский

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How light affects the life of Botrytis

Fungal Genetics and Biology, Journal Year: 2017, Volume and Issue: 106, P. 26 - 41

Published: June 23, 2017

Fungi, like other organisms, actively sense the environmental light conditions in order to drive adaptive responses, including protective mechanisms against light-associated stresses, and regulate development. Ecological niches are characterized by different regimes, for instance is absent underground, spectra from sunlight changed underwater or under canopy of foliage due absorption distinct wavelengths bacterial, algal plant pigments. Considering fact that fungi have evolved adapt their habitats, complexities 'visual' systems may vary significantly. Fungi pathogenic on plants experience a special regime because host always seeks optimum photosynthesis – pathogen has cope with this environment. When lives indirectly exposed sunlight, it confronted an altered spectrum enriched green far-red light. Botrytis cinerea, gray mold fungus, aggressive mainly infecting above-ground parts plant. As outlined review, Leotiomycete maintains highly sophisticated signaling machinery, integrating (near)-UV, blue, green, red signals use at least eleven potential photoreceptors trigger variety i.e. protection (pigmentation, enzymatic systems), morphogenesis (conidiation, apothecial development), entrainment circadian clock, positive negative tropism multicellular (conidiophores, apothecia) unicellular structures (conidial germ tubes). In sense, 'looking through eyes' will expand our knowledge fungal photobiology.

Language: Английский

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Fungal photobiology: visible light as a signal for stress, space and time

Current Genetics, Journal Year: 2014, Volume and Issue: 61(3), P. 275 - 288

Published: Oct. 16, 2014

Language: Английский

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Light in the Fungal World: From Photoreception to Gene Transcription and Beyond

Annual Review of Genetics, Journal Year: 2019, Volume and Issue: 53(1), P. 149 - 170

Published: Aug. 27, 2019

Fungi see light of different colors by using photoreceptors such as the White Collar proteins and cryptochromes for blue light, opsins green phytochromes red light. Light regulates fungal development, promotes accumulation protective pigments proteins, tropic growth. The complex (WCC) is a photoreceptor transcription factor that responsible regulating after exposure to In Neurospora crassa, interaction WCCs their binding promoters activate transcription. Aspergillus nidulans, WCC phytochrome interact coordinate gene other responses, but contribution these photobiology varies across species. Ultimately, effect on biology result coordinated transcriptional regulation activation signal transduction pathways.

Language: Английский

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Fungi use the SakA (HogA) pathway for phytochrome-dependent light signalling

Nature Microbiology, Journal Year: 2016, Volume and Issue: 1(5)

Published: Feb. 29, 2016

Language: Английский

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