Evolution and implementation of One Health to control the dissemination of antibiotic-resistant bacteria and resistance genes: A review

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 12

Published: Jan. 16, 2023

Antibiotic resistance is a serious threat to humanity and its environment. Aberrant usage of antibiotics in the human, animal, environmental sectors, as well dissemination resistant bacteria genes among these sectors globally, are all contributing factors. In humans, generally used treat infections prevent illnesses. food-producing animals has lately emerged major public health concern. These medicines currently being utilized infectious diseases also for growth-promoting qualities. methods have resulted induction spread antibiotic from humans. Antibiotics can be introduced into environment variety sources, including human wastes, veterinary livestock husbandry waste. The soil been recognized reservoir ABR genes, not only because presence wide varied range capable producing natural but manure on crop fields, which may contain or antibiotics. Fears about hazards related residues include possible modifying microbiota promoting rise selection bacteria, danger generating pressure microflora resulting resistance. Because connectivity use, residue persistence, existence antibiotic-resistant human-animal-environment habitats linked One Health triangle. pillars support rigorous surveillance different individually combination, at national international level, overcoming laboratory resource challenges, core plan action execution should strictly implemented combat under one approach. Implementing could help avoid emergence while healthier World. This review aims emphasize regulatory approaches perspective by highlighting interconnectedness multi-sectoral nature ill-health facets.

Language: Английский

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Colistin: from the shadows to a One Health approach for addressing antimicrobial resistance

International Journal of Antimicrobial Agents, Journal Year: 2023, Volume and Issue: 61(2), P. 106713 - 106713

Published: Jan. 11, 2023

Language: Английский

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Global Strategies to Combat Antimicrobial Resistance: A One Health Perspective

Pharmacology &amp Pharmacy, Journal Year: 2023, Volume and Issue: 14(08), P. 271 - 328

Published: Jan. 1, 2023

Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and environment. Developing implementing strategies reduce combat AMR critical. Purpose: This study aimed highlight some can be implemented address using One Health approach. Methods: employed narrative review design included studies published from January 2002 July 2023. The searched for literature on antimicrobial stewardship (AMS) PubMed Google Scholar 2020 PRISMA guidelines. Results: reveals remains significant public problem. Its severity been markedly exacerbated by broader ecological Several have developed AMR, including Global Action Plan (GAP), National Plans (NAPs), AMS programs, implementation AWaRe classification antimicrobials. These also involve strengthening surveillance consumption resistance, encouraging development new antimicrobials, enhancing regulations around prescribing, dispensing, usage. Additional measures include promoting partnerships, combating substandard falsified advocating vaccinations, sanitation, hygiene biosecurity, as well exploring alternatives However, these faces various challenges. challenges low awareness knowledge shortage human resources capacity building AMS, adequate funding initiatives, limited laboratory capacities surveillance, behavioural change issues, ineffective leadership multidisciplinary teams. Conclusion: In conclusion, this established prevalent among Successfully addressing calls collaborative, multifaceted Despite this, gaps remain effectively currently recommended AMR. As result, it essential reinforce are deployed counter across human, animal, environmental sectors.

Language: Английский

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Joining Forces against Antibiotic Resistance: The One Health Solution

Pathogens, Journal Year: 2023, Volume and Issue: 12(9), P. 1074 - 1074

Published: Aug. 23, 2023

Antibiotic resistance is a significant global health concern that affects both human and animal populations. The One Health approach acknowledges the interconnectedness of health, environment. It emphasizes importance collaboration coordination across these sectors to tackle complex challenges such as antibiotic resistance. In context Health, refers ability bacteria withstand efficacy antibiotics, rendering them less effective or completely ineffective in treating infections. emergence spread antibiotic-resistant pose threat well effectiveness medical treatments veterinary interventions. particular, recognizes use medicine, agriculture, environment are interconnected factors contributing development For example, misuse overuse antibiotics healthcare, including inappropriate prescribing patient non-compliance, can contribute selection resistant bacteria. Similarly, livestock production for growth promotion disease prevention animals subsequent transmission humans through food chain. Addressing requires collaborative involves multiple participants, healthcare professionals, veterinarians, researchers, policymakers.

Language: Английский

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Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond

Clinical Microbiology Reviews, Journal Year: 2023, Volume and Issue: 37(1)

Published: Dec. 14, 2023

SUMMARY Wastewater-based surveillance (WBS) has undergone dramatic advancement in the context of coronavirus disease 2019 (COVID-19) pandemic. The power and potential this platform technology were rapidly realized when it became evident that not only did WBS-measured SARS-CoV-2 RNA correlate strongly with COVID-19 clinical within monitored populations but also, fact, functioned as a leading indicator. Teams from across globe innovated novel approaches by which wastewater could be collected diverse sewersheds ranging treatment plants (enabling community-level surveillance) to more granular locations including individual neighborhoods high-risk buildings such long-term care facilities (LTCF). Efficient processes enabled extraction concentration highly dilute matrix. Molecular genomic tools identify, quantify, characterize its various variants adapted programs applied these mixed environmental systems. Novel data-sharing allowed information mobilized made immediately available public health government decision-makers even public, enabling evidence-informed decision-making based on local dynamics. WBS since been recognized tool transformative potential, providing near-real-time cost-effective, objective, comprehensive, inclusive data changing prevalence measured analytes space time populations. However, consequence rapid innovation hundreds teams simultaneously, tremendous heterogeneity currently exists literature. This manuscript provides state-of-the-art review established details current work underway expanding scope other infectious targets.

Language: Английский

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