Science in One Health, Journal Year: 2025, Volume and Issue: unknown, P. 100111 - 100111
Published: April 1, 2025
Language: Английский
Microorganisms, Journal Year: 2024, Volume and Issue: 12(4), P. 772 - 772
Published: April 11, 2024
Antibiotic resistance has emerged as a significant global public health issue, driven by the rapid adaptation of microorganisms to commonly prescribed antibiotics. Colistin, previously regarded last-resort antibiotic for treating infections caused Gram-negative bacteria, is increasingly becoming resistant due chromosomal mutations and acquisition genes carried plasmids, particularly mcr genes. The mobile colistin gene (mcr-1) was first discovered in E. coli from China 2016. Since that time, studies have reported different variants ranging mcr-1 mcr-10, mainly Enterobacteriaceae various parts world, which major concern health. co-presence colistin-resistant with other determinants further complicates treatment strategies underscores urgent need enhanced surveillance antimicrobial stewardship efforts. Therefore, understanding mechanisms driving monitoring its prevalence are essential steps addressing growing threat preserving efficacy existing This review critical role last-choice antibiotic, elucidates dissemination genes, explores evaluates current detection methods bacteria. objective shed light on these key aspects combating
Language: Английский
Citations
54
Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1920 - 1920
Published: Sept. 21, 2024
Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by widespread prevalence constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, selective pressure) contribute to the emergence dissemination resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention control strategies—IPCs) emphasize importance responsible antimicrobial use surveillance. A One Health approach interconnectedness human, animal, environmental health) highlights necessity for interdisciplinary collaboration holistic in combating AMR. Advancements novel therapeutics alternative agents vaccines) offer promising avenues addressing challenges. Policy interventions at international national levels also promote ASPs aiming regulate use. Despite all observed progress, remains pressing concern, demanding sustained efforts address emerging threats sustainability. Future research must prioritize innovative approaches complex socioecological dynamics This manuscript resource researchers, policymakers, healthcare professionals seeking navigate develop effective mitigation.
Language: Английский
Citations
25
Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 93 - 93
Published: Jan. 9, 2025
The growing prevalence of antibiotic-resistant bacteria within the human microbiome has become a pressing global health crisis. While antibiotics have revolutionized medicine by significantly reducing mortality and enabling advanced medical interventions, their misuse overuse led to emergence resistant bacterial strains. Key resistance mechanisms include genetic mutations, horizontal gene transfer, biofilm formation, with microbiota acting as reservoir for antibiotic genes (ARGs). Industrialization environmental factors exacerbated this issue, contributing rise in infections multidrug-resistant (MDR) bacteria, such methicillin-resistant Staphylococcus aureus (MRSA) carbapenem-resistant Enterobacteriaceae. These pathogens compromise effectiveness essential treatments like surgical prophylaxis chemotherapy, increase healthcare costs, prolong hospital stays. This crisis highlights need One-Health approach, particularly regions weak regulatory frameworks. Innovative strategies, including next-generation sequencing (NGS) technologies, offer promising avenues mitigating resistance. Addressing challenge requires coordinated efforts, encompassing research, policymaking, public education, stewardship, safeguard current foster development new therapeutic solutions. An integrated, multidimensional strategy is tackle escalating problem ensure sustainability effective antimicrobial treatments.
Language: Английский
Citations
5
Antibiotics, Journal Year: 2023, Volume and Issue: 12(11), P. 1580 - 1580
Published: Oct. 30, 2023
Recent advancements in sequencing technology and data analytics have led to a transformative era pathogen detection typing. These developments not only expedite the process, but also render it more cost-effective. Genomic analyses of infectious diseases are swiftly becoming standard for analysis control. Additionally, national surveillance systems can derive substantial benefits from genomic data, as they offer profound insights into epidemiology emergence antimicrobial-resistant strains. Antimicrobial resistance (AMR) is pressing global public health issue. While clinical laboratories traditionally relied on culture-based antimicrobial susceptibility testing, integration AMR holds immense promise. Genomic-based furnish swift, consistent, highly accurate predictions phenotypes specific strains or populations, all while contributing invaluable surveillance. Moreover, genome assumes pivotal role investigation hospital outbreaks. It aids identification infection sources, unveils genetic connections among isolates, informs strategies The One Health initiative, with its focus intricate interconnectedness humans, animals, environment, seeks develop comprehensive approaches disease surveillance, control, prevention. When integrated epidemiological systems, forecast expansion bacterial populations species transmissions. Consequently, this provides evolution relationships pathogens, hosts, environment.
Language: Английский
Citations
28
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3080 - 3080
Published: March 7, 2024
This paper sheds light on the alarming issue of antibiotic resistance (ABR) in aquatic environments, exploring its detrimental effects ecosystems and public health. It examines multifaceted role use aquaculture, agricultural runoff, industrial waste fostering development dissemination resistant bacteria. The intricate interplay between various environmental factors, horizontal gene transfer, bacterial extracellular vesicles (BEVs) accelerating spread ABR is comprehensively discussed. Various BEVs carrying genes like blaCTX-M, tetA, floR, sul/I, as well their contribution to dominance multidrug-resistant bacteria, are highlighted. potential both a threat tool combating explored, with promising strategies targeted antimicrobial delivery systems probiotic-derived EVs holding significant promise. underscores urgency understanding environments. By unraveling these unseen weapons, we pave way for developing effective mitigate ABR, advocating multidisciplinary approach that includes stringent regulations, enhanced wastewater treatment, adoption sustainable practices aquaculture.
Language: Английский
Citations
14
Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115574 - 115574
Published: Jan. 1, 2025
Language: Английский
Citations
1
Food Control, Journal Year: 2024, Volume and Issue: 160, P. 110380 - 110380
Published: Feb. 13, 2024
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4329 - 4329
Published: April 13, 2024
Shigellosis is a severe gastrointestinal disease that annually affects approximately 270 million individuals globally. It has particularly high morbidity and mortality in low-income regions; however, it not confined to these regions occurs high-income nations when conditions allow. The ill effects of shigellosis are at their highest children ages 2 5, with survivors often exhibiting impaired growth due infection-induced malnutrition. escalating threat antibiotic resistance further amplifies as serious public health concern. This review explores Shigella pathology, primary focus on the status vaccine candidates. These candidates include killed whole-cells, live attenuated organisms, LPS-based, subunit vaccines. strengths weaknesses each vaccination strategy considered. discussion includes potential immunogens, such LPS, conserved T3SS proteins, outer membrane diverse animal models used research, innovative development approaches. Additionally, this addresses ongoing challenges necessitate action toward advancing effective prevention control measures.
Language: Английский
Citations
8
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 920, P. 170635 - 170635
Published: Feb. 8, 2024
Considerable attention is given to intensive care unit-acquired infections; however, research on the transmission dynamics of multichain carbapenemase-resistant Enterobacter cloacae complex (CRECC) outbreaks remains elusive. A total 118 non-duplicated CRECC strains were isolated from clinical, intestinal, and hospital sewage samples collected Zhejiang province China during 2022–2023. 64 samples, their prevalence increased 10.0 % (95 confidence interval, CI = 0.52–45.8 %) in 2022 63.6 31.6–87.6 2023. Species-specific identification revealed that hormaechei was predominant species this study (53.4 %, 95 44.0–62.6 %). The antimicrobial susceptibility profiles indicated all conferred high-level resistance β-lactam antibiotics, ceftacillin/avibactam, polymyxin. Furthermore, exhibited β-lactams, quinolones, fosfomycin, with a higher colistin rate observed (67.2 54.2–78.1 Several antibiotic genes identified strains, including Class carbapenemases (blaKPC-2) B (blaNDM-1/blaIMP), but not D carbapenemases. WGS analysis showed majority carried carbapenemase-encoding genes, blaNDM-1 being most prevalent (86.9 77.4–92.9 sequence typing belonged diverse types (STs), among which ST418 blaNDM-positive strain. high risk carbapenemase-producing E. blaNDM-harboring IncFIB-type plasmid (81.4 72.9–87.7 detected emphasized study. This provides valuable insights into prevalence, resistance, genomic characteristics, populations environments. clonal relatedness sporadic supporting inter-hospital transmission.
Language: Английский
Citations
6
Pharmacology & Pharmacy, Journal Year: 2024, Volume and Issue: 15(12), P. 403 - 465
Published: Jan. 1, 2024
Language: Английский
Citations
6