Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(6), P. 723 - 723
Published: June 18, 2024
Wound
infections
may
disrupt
the
normal
wound-healing
process.
Large
amounts
of
antibiotics
are
frequently
used
to
prevent
pathogenic
infections;
however,
this
can
lead
resistance
development.
Biomaterials
possessing
antimicrobial
properties
have
promising
applications
for
reducing
antibiotic
usage
and
promoting
wound
healing.
Silk
sericin
(SS)
has
been
increasingly
explored
skin
healing
owing
its
excellent
biocompatibility
antioxidant,
antimicrobial,
ultraviolet-resistant
properties.
In
recent
years,
SS-based
composite
biomaterials
with
a
broader
spectrum
extensively
investigated
demonstrated
favorable
efficacy
in
This
review
summarizes
various
agents,
including
metal
nanoparticles,
natural
extracts,
antibiotics,
that
incorporated
into
SS
composites
elucidates
their
mechanisms
action.
It
revealed
achieve
sustained
activity
by
slow-release-loaded
agents.
The
antimicrobial-loaded
promote
through
anti-infection,
anti-inflammation,
hemostasis,
angiogenesis,
collagen
deposition.
manufacturing
methods,
benefits,
limitations
materials
briefly
discussed.
aims
enhance
understanding
new
advances
directions
guide
future
biomedical
research.
Infection and Drug Resistance,
Journal Year:
2020,
Volume and Issue:
Volume 13, P. 3255 - 3265
Published: Sept. 1, 2020
Abstract:
Methicillin-resistant
Staphylococcus
aureus
(MRSA)
is
a
major
human
pathogen
and
historically
emergent
zoonotic
with
public
health
veterinary
importance.
In
humans,
MRSA
commonly
causes
severe
infectious
diseases,
including
food
poisoning,
pyogenic
endocarditis,
suppurative
pneumonia,
otitis
media,
osteomyelitis,
infections
of
the
skin,
soft
tissues.
horse,
could
cause
localized
purulent
infection
botryomycosis;
in
cattle
ewe,
acute
mastitis
marked
toxemia;
sheep,
abscess
disease
resembles
caseous
lymphadenitis
caused
by
anaerobic
strains;
dogs
cats,
pustular
dermatitis
poisoning;
pig,
exudative
epidermatitis
"greasy
pig
disease;
birds,
bumble-foot.
The
methicillin
resistance
be
determined
PCR-based
detection
mec
A
gene
as
well
to
cefoxitin.
Egypt,
one
important
occasions
subclinical
clinical
bovine
mastitis,
prevalence
varies
geographical
region.
this
review,
we
are
trying
illustrate
variable
data
about
host
susceptibility,
epidemiology,
virulence
factors,
antibiotic
resistance,
treatment,
control
infection.
Keywords:
MRSA,
One
Health
Approach,
pathogenicity,
antimicrobial
treatment
Toxins,
Journal Year:
2021,
Volume and Issue:
13(10), P. 677 - 677
Published: Sept. 23, 2021
Staphylococcus
aureus
is
a
clinically
important
pathogen
that
causes
wide
range
of
human
infections,
from
minor
skin
infections
to
severe
tissue
infection
and
sepsis.
S.
has
high
level
antibiotic
resistance
common
cause
in
hospitals
the
community.
The
rising
prevalence
community-acquired
methicillin-resistant
(CA-MRSA),
combined
with
severity
general,
resulted
frequent
use
anti-staphylococcal
antibiotics,
leading
increasing
rates.
Antibiotic-resistant
continues
be
major
health
concern,
necessitating
development
novel
therapeutic
strategies.
uses
virulence
factors,
such
as
toxins,
develop
an
host.
Recently,
anti-virulence
treatments
directly
or
indirectly
neutralize
toxins
have
showed
promise.
In
this
review,
we
provide
update
on
toxin
pathogenic
characteristics,
well
anti-toxin
therapeutical
Infection and Immunity,
Journal Year:
2020,
Volume and Issue:
88(7)
Published: Feb. 24, 2020
Osteomyelitis,
or
inflammation
of
bone,
is
most
commonly
caused
by
invasion
bacterial
pathogens
into
the
skeleton.
Bacterial
osteomyelitis
notoriously
difficult
to
treat,
in
part
because
widespread
antimicrobial
resistance
preeminent
etiologic
agent,
Gram-positive
bacterium
Staphylococcus
aureus
.
triggers
pathological
bone
remodeling,
which
turn
leads
sequestration
infectious
foci
from
innate
immune
effectors
and
systemically
delivered
antimicrobials.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: April 6, 2023
Bacterial
biofilms
are
complex
microbial
communities
encased
in
extracellular
polymeric
substances.
Their
formation
is
a
multi-step
process.
Biofilms
significant
problem
treating
bacterial
infections
and
one
of
the
main
reasons
for
persistence
infections.
They
can
exhibit
increased
resistance
to
classical
antibiotics
cause
disease
through
device-related
non-device
(tissue)
-associated
infections,
posing
severe
threat
global
health
issues.
Therefore,
early
detection
search
new
alternative
treatments
essential
suppressing
biofilm-associated
In
this
paper,
we
systematically
reviewed
biofilms,
associated
methods,
potential
treatment
strategies,
aiming
provide
researchers
with
latest
progress
biofilms.
BMC Veterinary Research,
Journal Year:
2022,
Volume and Issue:
18(1)
Published: March 24, 2022
Abstract
Staphylococcus
aureus
is
a
leading
cause
of
bovine
mastitis
worldwide.
Despite
some
improved
understanding
disease
pathogenesis,
progress
towards
new
methods
for
the
control
intramammary
infections
(IMI)
has
been
limited,
particularly
in
field
vaccination.
Although
herd
management
programs
have
helped
to
reduce
number
clinical
cases,
S.
remains
major
burden.
This
review
summarizes
past
16
years
research
on
population
genetics,
and
molecular
pathogenesis
that
conducted
We
describe
diversity
associated
with
geographical
distribution
clones
different
continents.
also
studies
investigating
evolution
importance
host-adaptation
its
emergence
as
pathogen.
The
available
information
prevalence
virulence
determinants
their
functional
relevance
during
are
discussed.
traits
such
biofilm
formation
innate
immune
evasion
critical
persistence
bacteria,
current
key
host-pathogen
interactions
determine
outcome
IMI
very
limited.
suggest
greater
investment
into
genetic
basis
essential
identification
novel
therapeutic
vaccine
targets.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: July 7, 2021
is
one
of
the
most
important
human
pathogens
worldwide.
Its
high
antibiotic
resistance
profile
reinforces
need
for
new
interventions
like
vaccines
in
addition
to
antibiotics.
Vaccine
development
efforts
against
Toxins,
Journal Year:
2022,
Volume and Issue:
14(7), P. 464 - 464
Published: July 6, 2022
Staphylococcus
aureus
is
a
very
common
Gram-positive
bacterium,
and
S.
infections
play
an
extremely
important
role
in
variety
of
diseases.
This
paper
describes
the
types
virulence
factors
involved,
inflammatory
cells
activated,
process
host
cell
death,
associated
diseases
caused
by
aureus.
can
secrete
enterotoxins
other
toxins
to
trigger
responses
activate
cells,
such
as
keratinocytes,
helper
T
innate
lymphoid
macrophages,
dendritic
mast
neutrophils,
eosinophils,
basophils.
Activated
express
various
cytokines
induce
response.
also
death
through
pyroptosis,
apoptosis,
necroptosis,
autophagy,
etc.
article
discusses
MRSA
(methicillin-resistant
aureus)
atopic
dermatitis,
psoriasis,
pulmonary
cystic
fibrosis,
allergic
asthma,
food
poisoning,
sarcoidosis,
multiple
sclerosis,
osteomyelitis.
Summarizing
pathogenic
mechanism
provides
basis
for
targeted
treatment
infection.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(1), P. 87 - 87
Published: Jan. 4, 2023
is
a
microorganism
frequently
associated
with
implant-related
infections,
owing
to
its
ability
produce
biofilms.
These
infections
are
difficult
treat
because
antimicrobials
must
cross
the
biofilm
effectively
inhibit
bacterial
growth.
Although
some
antibiotics
can
penetrate
and
reduce
load,
it
important
understand
that
results
of
routine
sensitivity
tests
not
always
valid
for
interpreting
activity
different
drugs.
In
this
review,
broad
discussion
on
genes
involved
in
formation,
quorum
sensing,
antimicrobial
monotherapy
combination
therapy
presented
should
benefit
researchers
engaged
optimizing
treatment
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(12), P. 11692 - 11712
Published: June 13, 2023
Acute
methicillin
resistant
Staphylococcus
aureus
(MRSA)
pneumonia
is
one
of
the
most
frequently
seen
lung
infection
diseases
with
high
morbidity
and
mortality.
It
urgent
to
explore
an
efficient
antibacterial
strategy
owing
increase
drug
resistance,
virulence,
pathogenicity
MRSA.
was
found
that
Fe3O4
can
induce
ferroptosis
in
MRSA,
but
its
effect
inhibited
by
glutathione
(GSH)
a
certain
extent,
while
cinnamaldehyde
(CA)
enhance
consuming
GSH.
As
bacterial
quorum
sensing
(QS)
inhibitor,
CA
suppress
QS
system
further
exert
antibiofilm
effects.
Here,
we
developed
Fe3O4-based
inducer
promote
interrupt
QS,
destroy
biofilm,
thus
effectively
treat
acute
MRSA
pneumonia.
We
used
sodium
alginate
(SA)
wrap
form
particles,
then
coated
surface
hybrid
biomimetic
membrane
composed
erythrocyte
platelet
obtain
targeted
particles
(mFe-CA).
Under
ultrasonic
(US)
stimulation,
mFe-CA
efficiently
release
CA,
thereby
synergically
inducing
death
characteristics
ferroptosis,
including
mass
ROS
production,
lipid
peroxidation,
GSH
depletion,
respiratory
chain
suppression.
Furthermore,
+
US
inhibit
system,
remove
biofilms,
reduce
strain
virulence.
In
mouse
model
pneumonia,
treatment
markedly
advanced
survival
rate
mice,
reduced
load
lungs,
alleviated
inflammatory
damage,
there
no
obvious
toxicity.
This
study
proposes
substitute
which
may
provide
foreground
for
overcoming
microbial
resistance
fighting
biofilm-associated
infections
also
provides
target
theoretical
basis
clinical
Current Research in Immunology,
Journal Year:
2023,
Volume and Issue:
4, P. 100057 - 100057
Published: Jan. 1, 2023
The
research
interest
of
the
scientific
community
in
biofilm-forming
microorganisms
is
growing
due
to
problems
caused
by
their
infections
affecting
humans
and
animals,
mainly
because
difficulty
host
immune
system
eradicating
these
microbial
complex
communities
increasing
antimicrobial
resistance
rates
worldwide.
This
review
describes
virulence
factors
interaction
with
four
well-known
highly
pathogens,
more
exactly,
Pseudomonas
aeruginosa,
Escherichia
coli,
Staphylococcus
spp.,
Candida
spp.
innate
adaptive
responses
infection
evasion
biofilm
formation
are
discussed
present
work.
relevance
differences
expression
certain
response
biofilm-associated
when
compared
planktonic
usually
described
as
architecture
protects
pathogen
alters
responses,
here
we
extensively
mechanisms.
