Secondary metabolism in Trichoderma – Chemistry meets genomics

Fungal Biology Reviews, Journal Year: 2016, Volume and Issue: 30(2), P. 74 - 90

Published: May 31, 2016

Species of the genus Trichoderma inhabit diverse environments and undergo a variety interactions with different other organisms. Mycoparasitic species are successfully applied as bio-fungicides due to their plant-protecting abilities they prolific producers secondary metabolites which comes along an enrichment in metabolism-associated genes genomes. The objective this article is review produced by spp. comprehensive overview genomic content for gene clusters being involved metabolite biosynthesis. We discuss bioactivity selected Trichoderma-derived focus on roles plants fungal preys give methods profiling.

Language: Английский

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Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei

Applied Microbiology and Biotechnology, Journal Year: 2018, Volume and Issue: 102(22), P. 9481 - 9515

Published: Oct. 6, 2018

This review presents an update on the current knowledge of secondary metabolite potential major fungal species used in industrial biotechnology, i.e., Aspergillus niger, oryzae, and Trichoderma reesei. These have a long history safe use for enzyme production. Like most microorganisms that exist challenging environment nature, these fungi can produce large variety number metabolites. Many compounds present several properties make them attractive different medical applications. A description all known metabolites produced by is presented here. Mycotoxins are very limited group be pose health hazards humans other vertebrates when ingested small amounts. Some mycotoxins species-specific. Here, we scientific basis (1) definition including their toxicity (2) clarity misclassification mycotoxin reported literature, e.g., A. oryzae has been wrongly as aflatoxin producer, due to flavus strains. It therefore paramount importance accurately describe potentially production organism ensure strains not capable producing during intended reference paper authorities, companies, researchers dealing with assessment, risk evaluation food or feed production, considerations hosts.

Language: Английский

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Evolution and comparative genomics of the most common Trichoderma species

BMC Genomics, Journal Year: 2019, Volume and Issue: 20(1)

Published: June 12, 2019

The growing importance of the ubiquitous fungal genus Trichoderma (Hypocreales, Ascomycota) requires understanding its biology and evolution. Many species are used as biofertilizers biofungicides T. reesei is model organism for industrial production cellulolytic enzymes. In addition, some highly opportunistic devastate mushroom farms can become pathogens humans. A comparative analysis first three whole genomes revealed mycoparasitism innate feature Trichoderma. However, evolution these traits not yet understood.

Language: Английский

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Regulators of plant biomass degradation in ascomycetous fungi

Biotechnology for Biofuels, Journal Year: 2017, Volume and Issue: 10(1)

Published: June 12, 2017

Fungi play a major role in the global carbon cycle because of their ability to utilize plant biomass (polysaccharides, proteins, and lignin) as source. Due complexity heterogenic composition biomass, fungi need produce broad range degrading enzymes, matching (part of) prevalent substrate. This process is dependent on network regulators that not only control extracellular enzymes degrade but also metabolic pathways needed metabolize resulting monomers. review will summarize current knowledge regulation utilization compare differences between fungal species, focusing particular presence or absence involved this process.

Language: Английский

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Molecular dialogues between Trichoderma and roots: Role of the fungal secretome

Fungal Biology Reviews, Journal Year: 2018, Volume and Issue: 32(2), P. 62 - 85

Published: Jan. 19, 2018

Language: Английский

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Mycoparasitism as a mechanism of Trichoderma-mediated suppression of plant diseases

Fungal Biology Reviews, Journal Year: 2021, Volume and Issue: 39, P. 15 - 33

Published: Dec. 1, 2021

Language: Английский

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Molecular interaction between plants and Trichoderma species against soil-borne plant pathogens

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: May 15, 2023

Trichoderma spp. (Hypocreales) are used worldwide as a lucrative biocontrol agent. The interactions of with host plants and pathogens at molecular level important in understanding the various mechanisms adopted by fungus to attain close relationship their plant through superior antifungal/antimicrobial activity. When working synchrony, mycoparasitism, antibiosis, competition, induction systemic acquired resistance (SAR)-like response considered key factors deciding potential . Sucrose-rich root exudates attract soluble secretome plays significant role attachment penetration colonization roots, well modulating mycoparasitic antibiosis activity Trichoderma. This review aims gather information on how interacts its agent soil-borne phytopathogens, give comprehensive account diverse aspects this interaction.

Language: Английский

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Identification of effector-like proteins in Trichoderma spp. and role of a hydrophobin in the plant-fungus interaction and mycoparasitism

BMC Genomic Data, Journal Year: 2017, Volume and Issue: 18(1)

Published: Feb. 15, 2017

Trichoderma spp. can establish beneficial interactions with plants by promoting plant growth and defense systems, as well as, antagonizing fungal phytopathogens in mycoparasitic interactions. Such depend on signal exchange between both participants be mediated effector proteins that alter the host cell structure function, allowing establishment of relationship. The main purpose this work was to identify, using computational methods, candidates from T. virens, atroviride reesei, validate expression some genes during a interaction mycoparasitism define biological function for one them. We defined catalogue putative reesei. further validated 16 encoding virens Arabidopsis thaliana, two anastomosis groups phytopathogenic fungus Rhizoctonia solani. found which transcript levels are modified response presence fungi, respond only either or host. Further, we show overexpression gene tvhydii1, Class II hydrophobin family member, enhances antagonistic activity against R. solani AG2. deletion tvhydii1 results reduced colonization roots, while its increases it. Our is able different ways host, it even distinguish strains fungi given species. identified here may play roles preventing perception hosts, favoring protecting host's response. Finally, novel protein TVHYDII1 plays role root T, participates

Language: Английский

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The Apoplastic Secretome of Trichoderma virens During Interaction With Maize Roots Shows an Inhibition of Plant Defence and Scavenging Oxidative Stress Secreted Proteins

Frontiers in Plant Science, Journal Year: 2018, Volume and Issue: 9

Published: April 5, 2018

In Nature, almost every plant is colonized by fungi. Trichoderma virens a biocontrol fungus which has the capacity to behave as an opportunistic endophyte. Even though many plants are this symbiont, exact mechanisms masks its entrance into host remain unknown, but likely involve secretion of different families proteins apoplast that may play crucial roles in suppression immune responses. study, we investigated T. colonization maize roots under hydroponic conditions, evidencing inter- and intracellular modifications root morphology coloration. Moreover, show upon penetration, secretes arsenal facilitate tissues. Using gel-free shotgun proteomics approach, 95 43 secretory were identified from virens, respectively. A reduction secretome (36%) was induced including two major groups, glycosyl hydrolases peroxidases. Furthermore, secreted mainly involved cell wall hydrolysis, scavenging reactive oxygen species secondary metabolism, well putative effector-like proteins. Levels peroxidase activity reduced inoculated roots, suggesting strategy used manipulate The results provide insight crosstalk essential maintain virens-plant interaction.

Language: Английский

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Fungicolous fungi: terminology, diversity, distribution, evolution, and species checklist

Fungal Diversity, Journal Year: 2019, Volume and Issue: 95(1), P. 337 - 430

Published: March 1, 2019

Language: Английский

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