The amazing potential of fungi: 50 ways we can exploit fungi industrially

Fungal Diversity, Journal Year: 2019, Volume and Issue: 97(1), P. 1 - 136

Published: July 1, 2019

Fungi are an understudied, biotechnologically valuable group of organisms. Due to the immense range habitats that fungi inhabit, and consequent need compete against a diverse array other fungi, bacteria, animals, have developed numerous survival mechanisms. The unique attributes thus herald great promise for their application in biotechnology industry. Moreover, can be grown with relative ease, making production at scale viable. search fungal biodiversity, construction living collection, both incredible economic potential locating organisms novel industrial uses will lead products. This manuscript reviews fifty ways which potentially utilized as biotechnology. We provide notes examples each exploitation give from our own work notable researchers. also flow chart used convince funding bodies importance biotechnological research provided world penicillin, lovastatin, globally significant medicines, they remain untapped resource enormous potential.

Language: Английский

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Plant health: feedback effect of root exudates-rhizobiome interactions

Applied Microbiology and Biotechnology, Journal Year: 2018, Volume and Issue: 103(3), P. 1155 - 1166

Published: Dec. 20, 2018

The well-being of the microbial community that densely populates rhizosphere is aided by a plant's root exudates. Maintaining health key factor in its continued existence. As minute as rhizospheric microbes are, their importance plant growth cannot be overemphasized. They depend on plants for nutrients and other necessary requirements. relationship between rhizosphere-microbiome (rhizobiome) hosts can beneficial, non-effectual, or pathogenic depending involved. This relationship, to large extent, determines fate host survival. Modern molecular techniques have been used unravel rhizobiome species' composition, but interplay exudates factors maintenance healthy not yet thoroughly investigated. Many functional proteins are activated upon contact with external factors. These may elicit promoting suppressing responses from plants. To optimize productivity plants, diversity modulatory need clearly understood improved health.

Language: Английский

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Carbon Catabolite Repression in Filamentous Fungi

International Journal of Molecular Sciences, Journal Year: 2017, Volume and Issue: 19(1), P. 48 - 48

Published: Dec. 24, 2017

Carbon Catabolite Repression (CCR) has fascinated scientists and researchers around the globe for past few decades. This important mechanism allows preferential utilization of an energy-efficient readily available carbon source over relatively less easily accessible sources. helps microorganisms to obtain maximum amount glucose in order keep pace with their metabolism. Microorganisms assimilate highly favorable sugars before switching less-favored sources such as organic acids alcohols. In CCR filamentous fungi, CreA acts a transcription factor, which is regulated some extent by ubiquitination. CreD-HulA ubiquitination ligase complex ubiquitination, while CreB-CreC deubiquitination (DUB) removes ubiquitin from CreA, causes its activation. fungi also involves very crucial elements Hexokinases, cAMP, Protein Kinase (PKA), Ras proteins, G protein-coupled receptor (GPCR), Adenylate cyclase, RcoA SnfA. Thorough study molecular understanding growth, conidiation, virulence survival fungi. review comprehensive revision regulation well updated summary key regulators, different CCR-dependent mechanisms impact on various physical characteristics

Language: Английский

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Fungal Cell Factories for Efficient and Sustainable Production of Proteins and Peptides

Microorganisms, Journal Year: 2022, Volume and Issue: 10(4), P. 753 - 753

Published: March 30, 2022

Filamentous fungi are a large and diverse taxonomically group of microorganisms found in all habitats worldwide. They grow as network cells called hyphae. Since filamentous live very habitats, they produce different enzymes to degrade material for their living, example hydrolytic various kinds biomasses. Moreover, defense proteins (antimicrobial peptides) attaching surfaces (hydrophobins). Many them easy cultivate known setups (submerged fermentation solid-state fermentation) secretion often much larger than what is seen from yeast bacteria. Therefore, many industries the preferred production hosts enzymes. Edible have traditionally been used food, such mushrooms or fermented foods. New trends use edible myco-protein enriched This review gives an overview proteins, enzymes, peptides produced by most well-known cell factories purposes applications. we describe some challenges that important consider when optimized efficient factories.

Language: Английский

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Combinatorial pretreatment and fermentation optimization enabled a record yield on lignin bioconversion

Biotechnology for Biofuels, Journal Year: 2018, Volume and Issue: 11(1)

Published: Jan. 29, 2018

Lignin valorization has recently been considered to be an essential process for sustainable and cost-effective biorefineries. represents a potential new feedstock value-added products. Oleaginous bacteria such as Rhodococcus opacus can produce intracellular lipids from biodegradation of aromatic substrates. These used biofuel production, which potentially replace petroleum-derived chemicals. However, the low reactivity lignin produced pretreatment underdeveloped fermentation technology hindered bioconversion lipids. In this study, combinatorial with optimized strategy was evaluated improve into using R. PD630.As opposed single pretreatment, 12.8-75.6% higher lipid concentration in carbon source. Gas chromatography-mass spectrometry analysis showed that released more monomers, could readily utilized by lignin-degrading strains. Three detoxification strategies were remove inhibitors pretreatment. After heating stream, further increased 2.9-9.7%. Different scale-up 2.0-l fermenter. With laccase treatment stream highest cell dry weight 10.1 1.83 g/l, respectively, fed-batch fermentation, total soluble substrate 40 g/l. The improvement performance may have resulted depolymerization treatment, reduced inhibition effects adequate oxygen supply, accurate pH control fermenter.Overall, these results demonstrate together optimization, favorably improves production Combinatorial integrated effective lipids, thus facilitating

Language: Английский

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Regulation of plant cell wall degradation by light in Trichoderma

Fungal Biology and Biotechnology, Journal Year: 2018, Volume and Issue: 5(1)

Published: April 24, 2018

Trichoderma reesei (syn. Hypocrea jecorina) is the model organism for industrial production of plant cell wall degradating enzymes. The integration light and nutrient signals adaptation enzyme in T. emerged as an important regulatory mechanism to be tackled strain improvement. Gene regulation specific cellulase inducing conditions different darkness with substantial by photoreceptors. Genes regulated are clustered genome, several clusters overlapping CAZyme clusters. Major transcription factor genes at least 75% glycoside hydrolase encoding show potential dependent regulation. Accordingly, protein complex formation occurs within promoters cellulases their regulators. Additionally growth on diverse carbon sources between presence photoreceptors cases. Thereby, also intensity plays a role, levels dropping higher intensities background. heterotrimeric G-protein pathway most signaling connection response triggers posttranscriptional expression. All alpha subunits impact manner. downstream cAMP involved well. Connections pathways mainly established via photoreceptor ENV1. effect degradation filamentous fungus Neurospora crassa. In currently proposed model, senses biomass its environment detection building blocks cellulose hemicellulose. Interpretation respective subsequently adjusted requirements (or surface versus substrate) interconnection response. This review provides overview importance light, related degrading enzymes reesei. Additionally, relevance gene fermentations well strategies exploitation observed effects discussed.

Language: Английский

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Engineered microbial host selection for value-added bioproducts from lignocellulose

Biotechnology Advances, Journal Year: 2019, Volume and Issue: 37(6), P. 107347 - 107347

Published: Feb. 13, 2019

Language: Английский

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The influence of feedstock characteristics on enzyme production in Trichoderma reesei: a review on productivity, gene regulation and secretion profiles

Biotechnology for Biofuels, Journal Year: 2019, Volume and Issue: 12(1)

Published: Oct. 8, 2019

Abstract Biorefineries, designed for the production of lignocellulose-based chemicals and fuels, are receiving increasing attention from public, governments, industries. A major obstacle biorefineries to advance commercial scale is high cost enzymes required derive fermentable sugars feedstock used. As summarized in this review, techno-economic studies suggest co-localization integration enzyme manufacturing with cellulosic biorefinery as most promising alternative alleviate problem. Thus, cultivation Trichoderma reesei , principal producer lignocellulolytic enzymes, on lignocellulosic biomass processed on-site can reduce manufacturing. Further, due a complex gene regulation machinery, fungus adjust expression towards characteristics feedstock, hydrolytic efficiency produced cocktail. Despite extensive research over decades, underlying regulatory mechanisms not fully elucidated. One aspect that has received relatively little literature influence substrate, i.e., its chemical physical composition, mixture. Considering dependent efficient enzymatic degradation lignocellulose continuous supply carbon energy, relationship between secretome composition be expected. The aim review was systematically collect, appraise, aggregate data integrate results analyzing by T. insoluble model substrates biomass. show there direct effect substrate’s complexity (rated structure, lignin–carbohydrate complex, recalcitrance saccharification) titers specific activities secretome. It further shows process-related factors, such substrate loading set-up, targets yields. transcriptome supports proposed substrate-related factors enzymes. This provides insights into interrelation which may help integrated substrate-specific cocktails at scale.

Language: Английский

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From lignocellulose to plastics: Knowledge transfer on the degradation approaches by fungi

Biotechnology Advances, Journal Year: 2021, Volume and Issue: 50, P. 107770 - 107770

Published: May 11, 2021

Language: Английский

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Microbiota drive insoluble polysaccharides utilization via microbiome-metabolome interplay during Pu-erh tea fermentation

Food Chemistry, Journal Year: 2022, Volume and Issue: 377, P. 132007 - 132007

Published: Jan. 4, 2022

Language: Английский

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