Mycobiome and Cancer: What Is the Evidence? DOI Open Access
Natalia G. Vallianou, Dimitris Kounatidis, Gerasimos Socrates Christodoulatos

et al.

Cancers, Journal Year: 2021, Volume and Issue: 13(13), P. 3149 - 3149

Published: June 24, 2021

Background: To date, most researchhas focused on the bacterial composition of human microbiota. In this review, we synopsize recent data mycobiome and cancer, highlighting specific cancer types based current available evidence, presenting interesting perspectives limitations studies laboratory methodologies. Recent findings: Head neck carcinoma (HNCC), colorectal (CRC) pancreatic ductal adenocarcinoma (PDA) have been associated with dissimilarities in mycobiota between cases non-cancer participants. Overall, fungal dysbiosis decreased richness diversity was common patients; however, a mycobiotic signature HNSCC or CRC has not emerged. Different strains Candida albicans identified among HNCC, whilst Lichtheimia corymbifera, member Mucoraceae family, shown to predominate patients oral tongue cancer. Virulence factors spp. include formation biofilm filamentation, secretion toxins metabolites. present dysregulated ratio Basidiomycota/Ascomycota. Abundance Malassezia linked occurrence progression PDA, particularly animal models PDA. Interestingly, Schizophyllum, component mycobiome, may exhibit anti-cancer potential. Conclusion: The per se, along its interactions bacteriome host, be implicated promotion carcinogenesis. Fungi used as diagnostic prognostic/predictive tools treatment targets for coming years. More large-scale, prospective, multicentric longitudinal an integrative multi-omics methodology are required examine precise contribution etiopathogenesis delineate whether changes that occur causal consequent

Language: Английский

Gut Mycobiota in Immunity and Inflammatory Disease DOI Creative Commons
Xin Li, Irina Leonardi, Iliyan D. Iliev

et al.

Immunity, Journal Year: 2019, Volume and Issue: 50(6), P. 1365 - 1379

Published: June 1, 2019

Language: Английский

Citations

187
Immune responses to human fungal pathogens and therapeutic prospects DOI Open Access
Michail S. Lionakis, Rebecca A. Drummond, Tobias M. Hohl

et al.

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(7), P. 433 - 452

Published: Jan. 4, 2023

Language: Английский

Citations

170
Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities DOI Creative Commons
Xiaoyan Wu, Yaoyao Xia, Fang He

et al.

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: March 14, 2021

Abstract Bacteria, viruses, protozoa, and fungi establish a complex ecosystem in the gut. Like other microbiota, gut mycobiota plays an indispensable role modulating intestinal physiology. Notably, most striking characteristics of are their extraintestinal functions. Here, we provide comprehensive review importance regulation intestinal, pulmonary, hepatic, renal, pancreatic, brain functions, present possible opportunities for application to alleviate/treat human diseases.

Language: Английский

Citations

111
Mapping the human gut mycobiome in middle-aged and elderly adults: multiomics insights and implications for host metabolic health DOI Creative Commons
Menglei Shuai, Yuanqing Fu,

Haili Zhong

et al.

Gut, Journal Year: 2022, Volume and Issue: 71(9), P. 1812 - 1820

Published: Jan. 11, 2022

Objective The human gut fungal community, known as the mycobiome, plays a fundamental role in ecosystem and health. Here we aimed to investigate determinants long-term stability of mycobiome among middle-aged elderly adults. We further explored interplay between fungi bacteria on metabolic Design present study included 1244 participants from Guangzhou Nutrition Health Study. characterised especially habitual dietary consumption. comprehensive multiomics analyses were performed ecological links bacteria, faecal metabolome. Finally, examined whether interaction could modulate risk. Results composition was temporally stable mainly determined by age, diet host physiological states. Specifically, compared with individuals, Blastobotrys Agaricomycetes spp depleted, while Malassezia enriched elderly. Dairy consumption positively associated Saccharomyces but inversely Candida . Notably, Saccharomycetales interacted bacterial diversity influence insulin resistance. Bidirectional mediation indicated that function or histidine might causally mediate an impact Pichia blood cholesterol. Conclusion depict sociodemographic reveal may be closely health through regulating functions metabolites.

Language: Английский

Citations

106
A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases DOI

Qiulong Yan,

Shenghui Li, Qingsong Yan

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(12), P. 2969 - 2989.e24

Published: May 21, 2024

Language: Английский

Citations

35
Fungi in the Gut Microbiota: Interactions, Homeostasis, and Host Physiology DOI Creative Commons
Haoyu Liu, Shicheng Li,

Kennedy Jerry Ogamune

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 70 - 70

Published: Jan. 2, 2025

The mammalian gastrointestinal tract is a stage for dynamic inter-kingdom interactions among bacteria, fungi, viruses, and protozoa, which collectively shape the gut micro-ecology influence host physiology. Despite being modest fraction, fungal community, also referred to as mycobiota, represents critical component of microbiota. Emerging evidence suggests that fungi act early colonizers intestine, exerting lasting on development. Meanwhile, composition mycobiota influenced by multiple factors, with diet, nutrition, drug use (e.g., antimicrobials), physical condition standing primary drivers. During its establishment, forms both antagonistic synergistic relationships bacterial communities within host. For instance, intestinal can inhibit colonization producing alcohol, while certain pathogens exploit iron carriers enhance their growth. However, regulatory mechanisms governing these complex remain poorly understood. In this review, we first introduce methodologies studying microbiota, then address significance in especially during weaning when all ‘primary drivers’ change, and, finally, discuss between bacteria under various influencing factors. Our review aims shed light dynamics homeostasis provide insights into how they be better understood managed improve health disease outcomes.

Language: Английский

Citations

4
Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities DOI
Iliyan D. Iliev, Ashwin N. Ananthakrishnan, Chun‐Jun Guo

et al.

Nature Reviews Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

3
Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model DOI Creative Commons
Xiaoyun Huang,

A. Johnson,

Joshua N. Brehm

et al.

mSphere, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

ABSTRACT Treatment with antibiotics is a major risk factor for Clostridioides difficile infection, likely due to depletion of the gastrointestinal microbiota. Two microbiota-mediated mechanisms thought limit C. colonization include conversion conjugated primary bile salts into secondary toxic growth and competition between microbiota limiting nutrients. Using continuous flow model that simulates nutrient conditions distal colon, we investigated how treatment 6 clinically used influenced susceptibility infection in 12 different microbial communities cultivated from healthy individuals. Antibiotic reduced richness; disruption varied by antibiotic class composition, but did not correlate susceptibility. also disrupted salt metabolism, increasing levels salt, cholate. However, changes increased Furthermore, were required inhibit colonization. We tested whether amino acid fermentation contributed persistence antibiotic-treated communities. mutants unable use proline as an electron acceptor Stickland reductase ( prdB −) had significantly lower than wild-type strains four six tested. The inability ferment glycine or leucine acceptors, however, was sufficient any data provide further support importance salt-independent regulating . IMPORTANCE one leading causes hospital-acquired infections antibiotic-associated diarrhea. Several potential through which can have been identified are targets new therapeutics. it unclear inhibition represent best development These studies demonstrate complex vitro resistance independent metabolism. Instead, ability colonize dependent upon its metabolize proline, although proline-dependent context observed all Altogether, these need work understand bile-independent regulate

Language: Английский

Citations

2
Longitudinal Survey of Fungi in the Human Gut: ITS Profiling, Phenotyping, and Colonization DOI Creative Commons
Stefano Raimondi, Alberto Amaretti, Caterina Gozzoli

et al.

Frontiers in Microbiology, Journal Year: 2019, Volume and Issue: 10

Published: July 10, 2019

The fungal component of the intestinal microbiota eight healthy subjects was studied over 12 months using metagenome survey and culture-based approaches. Aspergillus, Candida, Debaryomyces, Malassezia, Penicillium, Pichia, Saccharomyces were most recurrent and/or dominant genera, according to metagenomic analysis. biodiversity communities lower characterized by greater unevenness, when compared bacterial microbiome. dissimilarities both among time within same subject suggested that fungi passed through gastro-intestinal tract (GIT) without becoming stable colonizers. Certain such as Aspergillus isolated in a minority cases, although they recurred abundantly frequently metagenomics survey, likely being environmental or food-borne do not inhabit GIT. Candida genus recurrently detected. albicans isolates dominated cultivable mycobiota longitudinally persisted, commensals inhabiting intestine regularly reaching it from Candida-colonized districts, oral cavity. Other putative colonizers belonged C. zeylanoides, G. candidum, R. mucilaginosa, with persisting biotypes identified. Phenotyping indicated adhered human epithelial cells more efficiently produced amounts biofilm vitro than non-albicans (NAC) non-Candida (NCF). also induced highest release HBD-2 cells, further differing NAC NCF. Nine representative administered mice evaluate ability colonize intestine. Only two out three strains persisted stools animals weeks after end administration, whereas NCF did not. These results confirm allochthonous nature fungi, while appears be commonly involved colonization. A combination specific genetic features microbe host allow colonization normally present solely passengers. It remains established if other species identified potential colonizers, addition are true inhabitants GIT rather reach spreading body districts.

Language: Английский

Citations

121
Crossing Kingdoms: How the Mycobiota and Fungal-Bacterial Interactions Impact Host Health and Disease DOI Creative Commons
William Santus, Jason R. Devlin, Judith Behnsen

et al.

Infection and Immunity, Journal Year: 2021, Volume and Issue: 89(4)

Published: Feb. 1, 2021

The term “microbiota” invokes images of mucosal surfaces densely populated with bacteria. These and the luminal compartments they form indeed predominantly harbor

Language: Английский

Citations

101