Blautia—a new functional genus with potential probiotic properties?

Gut Microbes, Journal Year: 2021, Volume and Issue: 13(1)

Published: Jan. 1, 2021

Blautia is a genus of anaerobic bacteria with probiotic characteristics that occur widely in the feces and intestines mammals. Based on phenotypic phylogenetic analyses, some species genera Clostridium Ruminococcus have been reclassified as Blautia, so to date, there are 20 new valid published names this genus. An extensive body research has recently focused effects genus, such biological transformation its ability regulate host health alleviate metabolic syndrome. This article reviews origin factors affect abundance discusses role health, thus laying theoretical foundation for development functional microorganisms properties.

Language: Английский

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Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome

Gut, Journal Year: 2022, Volume and Issue: 71(3), P. 544 - 552

Published: Jan. 26, 2022

Background Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms viral clearance remains unclear. Objective To investigate whether gut microbiome composition is linked to post-acute syndrome (PACS), defined as at least one symptom 4 weeks of SARS-CoV-2 virus. Methods We conducted a prospective study 106 patients with spectrum severity followed up from admission 6 months and 68 non-COVID-19 controls. analysed serial faecal 258 samples using shotgun metagenomic sequencing, correlated results months. Results At months, 76% had PACS most common were fatigue, poor memory hair loss. Gut microbiota was associated occurrence PACS. Patients without showed recovered profile comparable that characterised by higher levels Ruminococcus gnavus , Bacteroides vulgatus lower Faecalibacterium prausnitzii . Persistent respiratory opportunistic pathogens, neuropsychiatric fatigue nosocomial including Clostridium innocuum Actinomyces naeslundii (all p<0.05). Butyrate-producing bacteria, Bifidobacterium pseudocatenulatum largest inverse correlations Conclusion These findings provided observational evidence compositional alterations in long-term COVID-19. Further studies should modulation can facilitate timely recovery syndrome.

Language: Английский

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Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 18, 2022

Abstract The gut microbiome is an important determinant in various diseases. Here we perform a cross-sectional study of Japanese adults and identify the Blautia genus, especially B. wexlerae , as commensal bacterium that inversely correlated with obesity type 2 diabetes mellitus. Oral administration to mice induce metabolic changes anti-inflammatory effects decrease both high-fat diet–induced diabetes. beneficial are unique amino-acid metabolism produce S-adenosylmethionine, acetylcholine, l -ornithine carbohydrate resulting accumulation amylopectin production succinate, lactate, acetate, simultaneous modification bacterial composition. These findings reveal regulatory pathways host microbial may provide novel strategies preventive therapeutic approaches for disorders.

Language: Английский

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Gut Microbiome in Progressive Multiple Sclerosis

Annals of Neurology, Journal Year: 2021, Volume and Issue: 89(6), P. 1195 - 1211

Published: April 20, 2021

Objective This study was undertaken to investigate the gut microbiome in progressive multiple sclerosis (MS) and how it relates clinical disease. Methods We sequenced microbiota from healthy controls relapsing–remitting MS (RRMS) patients correlated levels of bacteria with features disease, including Expanded Disability Status Scale (EDSS), quality life, brain magnetic resonance imaging lesions/atrophy. colonized mice MS‐derived Akkermansia induced experimental autoimmune encephalomyelitis (EAE). Results Microbiota β‐diversity differed between but did not differ RRMS or based on disease‐modifying therapies. Disease status had greatest effect β‐diversity, followed by body mass index, race, sex. In both RRMS, we found increased Clostridium bolteae , Ruthenibacterium lactatiformans decreased Blautia wexlerae Dorea formicigenerans Erysipelotrichaceae CCMM . Unique MS, elevated Enterobacteriaceae g24 FCEY Agathobaculum Several species were associated higher EDSS fatigue scores. Contrary view that has a detrimental role, linked lower disability, suggesting beneficial role. Consistent this, isolated ameliorated EAE, which reduction RORγt+ IL‐17–producing γδ T cells. Interpretation Whereas some alterations are shared relapsing identified unique measures Furthermore, may be compensatory response microbiome. ANN NEUROL 2021;89:1195–1211

Language: Английский

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Mechanism of the Gut Microbiota Colonization Resistance and Enteric Pathogen Infection

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Dec. 23, 2021

The mammalian gut microbial community, known as the microbiota, comprises trillions of bacteria, which co-evolved with host and has an important role in a variety functions that include nutrient acquisition, metabolism, immunity development, more importantly, it plays critical protection from enteric infections associated exogenous pathogens or indigenous pathobiont outgrowth may result healthy community disruption. Microbiota evolves complex mechanisms to restrain pathogen growth, included competition, competitive metabolic interactions, niche exclusion, induction immune response, are collectively termed colonization resistance. On other hand, have also developed counterstrategies expand their population enhance virulence cope microbiota resistance cause infection. This review summarizes available literature on relationship occurring between intestinal pathogens, describing how can mediate against bacterial enteropathogens overcome this well understanding interaction inform future therapies infectious diseases.

Language: Английский

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Arsenic exposure induces intestinal barrier damage and consequent activation of gut-liver axis leading to inflammation and pyroptosis of liver in ducks

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 788, P. 147780 - 147780

Published: May 15, 2021

Language: Английский

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Structure and fermentation characteristics of five polysaccharides sequentially extracted from sugar beet pulp by different methods

Food Hydrocolloids, Journal Year: 2021, Volume and Issue: 126, P. 107462 - 107462

Published: Dec. 28, 2021

Language: Английский

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Metabolite profiling of human‐originated Lachnospiraceae at the strain level

iMeta, Journal Year: 2022, Volume and Issue: 1(4)

Published: Oct. 13, 2022

Abstract The human gastrointestinal (GI) tract harbors diverse microbes, and the family Lachnospiraceae is one of most abundant widely occurring bacterial groups in GI tract. Beneficial adverse effects on host health were reported, but diversities at species/strain levels as well their metabolites have been, so far, not documented. In present study, we report collection 77 h uman‐originated L a ch nospiraceae sp ecies (please refer hLchsp, https://hgmb.nmdc.cn/subject/lachnospiraceae ) vitro metabolite profiles 110 strains ( https://hgmb.nmdc.cn/subject/lachnospiraceae/metabolites ). hLchsp produced 242 17 categories. larger categories alcohols (89), ketones (35), pyrazines (29), short (C2–C5), long (C > 5) chain acids (31), phenols (14), aldehydes other 30 compounds. Among them, 22 aromatic well‐known beneficial gut microbial metabolite, butyric acid, was generally by many strains, Agathobacter rectalis strain Lach‐101 Coprococcus comes NSJ‐173 top 2 acid producers, 331.5 310.9 mg/L vitro, respectively. Further analysis publicly available cohort‐based volatile‐metabolomic data sets feces revealed that over 30% prevailing volatile covered identified this study. This study provides resources together with metabolic for future studies host–microbe interactions developments novel probiotics or biotherapies.

Language: Английский

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Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 16, 2023

Abstract The interplay between western diet and gut microbiota drives the development of non-alcoholic fatty liver disease its progression to steatohepatitis. However, specific microbial metabolic mediators contributing steatohepatitis remain be identified. Here, a choline-low high-fat high-sugar diet, representing typical named CL-HFS, successfully induces male mouse with some features human disease, such as hepatic inflammation, steatosis, fibrosis. Metataxonomic metabolomic studies identify Blautia producta 2-oleoylglycerol clinically relevant bacterial CL-HFS-induced In vivo validate that both promote inflammation fibrosis in normal diet- or CL-HFS-fed mice. Cellular molecular reveal GPR119/TAK1/NF-κB/TGF-β1 signaling pathway mediates 2-oleoylglycerol-induced macrophage priming subsequent stellate cell activation. These findings advance our understanding pathogenesis provide targets for developing microbiome/metabolite-based therapeutic strategies against

Language: Английский

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Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(6), P. 996 - 1010.e4

Published: June 1, 2024

The composition and maturation of the early-life microbiota are modulated by a number perinatal factors, whose interplay in relation to microbial vertical transmission remains inadequately elucidated. Using recent strain-tracking methodologies, we analyzed mother-to-infant two different birth environments: hospital-born (vaginal/cesarean) home-born (vaginal) infants their mothers. While delivery mode primarily explains initial compositional differences, place impacts timing-being early homebirths delayed cesarean deliveries. Transmission patterns vary greatly across species groups, yet certain species, like Bifidobacterium longum, consistently vertically transmitted regardless setting. Strain-level analysis B. longum highlights relevant consistent subspecies replacement mainly explained breastfeeding practices, which drive changes human milk oligosaccharide (HMO) degrading capabilities. Our findings highlight how setting, duration, other lifestyle preferences collectively shape transmission, impacting infant gut colonization during life.

Language: Английский

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