Toxicology and Applied Pharmacology, Journal Year: 2022, Volume and Issue: 450, P. 116174 - 116174
Published: July 23, 2022
Language: Английский
ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 8190 - 8204
Published: May 4, 2022
In animal species, the brain–gut axis is a complex bidirectional network between gastrointestinal (GI) tract and central nervous system (CNS) consisting of numerous microbial, immune, neuronal, hormonal pathways that profoundly impact organism development health. Although nanoplastics (NPs) have been shown to cause intestinal neural toxicity in fish, role neurotransmitter microbiota interactions underlying mechanism toxicity, particularly at environmentally relevant contaminant concentrations, remains unknown. Here, effect 44 nm polystyrene (PS-NPs) on brain–intestine–microbe embryo–larval zebrafish (Danio rerio) was investigated. Exposure 1, 10, 100 μg/L PS-NPs for 30 days inhibited growth adversely affected inflammatory responses permeability. Targeted metabolomics analysis revealed an alteration 42 metabolites involved neurotransmission. The content 3,4-dihydroxyphenylacetic acid (DOPAC; dopamine metabolite formed by monoamine oxidase activity) significantly decreased dose-dependent manner after PS-NP exposure. Changes 14 correlated with changes 3 microbial groups, including Proteobacteria, Firmicutes, Bacteroidetes, as compared control group. A significant relationship Firmicutes homovanillic (0.466, Pearson correlation coefficient) evident. Eight altered (l-glutamine (Gln), 5-hydroxyindoleacetic (5-HIAA), serotonin, 5-hydroxytryptophan (5-HTP), l-cysteine (Cys), l-glutamic (Glu), norepinephrine (NE), l-tryptophan (l-Trp)) had negative Proteobacteria although histamine (His) acetylcholine chloride (ACh chloride) levels were positively Proteobacteria. An Associated Network showed Bacteroidetes highly (0.969). Furthermore, accumulated offspring impaired F1 (2 h post-fertilization) embryos, reduced spontaneous movements, hatching rate, length. This demonstration transgenerational deficits particular concern. These findings suggest inflammation, inhibition, restricted zebrafish, which are strongly linked disrupted regulation within brain–intestine–microbiota axis. Our study provides insights into how xenobiotics can disrupt suggests these end points should be taken account when assessing environmental health risks aquatic organisms.
Language: Английский
Citations
171
Chemosphere, Journal Year: 2022, Volume and Issue: 300, P. 134566 - 134566
Published: April 9, 2022
Language: Английский
Citations
60
Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 455, P. 131543 - 131543
Published: May 6, 2023
Language: Английский
Citations
33
Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11
Published: Feb. 24, 2023
Inflammatory bowel disease (IBD) is becoming increasingly prevalent with the improvement of people's living standards in recent years, especially urban areas. The emerging environmental contaminant a newly-proposed concept progress industrialization and modernization, referring to synthetic chemicals that were not noticed or researched before, which may lead many chronic diseases, including IBD. contaminants mainly include microplastics, endocrine-disrupting chemicals, chemical herbicides, heavy metals, persisting organic pollutants. In this review, we summarize adverse health effect these on humans their relationships Therefore, can better understand impact new IBD, minimize exposures, lower future incidence
Language: Английский
Citations
31
Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117134 - 117134
Published: Sept. 14, 2023
Language: Английский
Citations
28
The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 167215 - 167215
Published: Sept. 19, 2023
Language: Английский
Citations
28
Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123732 - 123732
Published: March 8, 2024
The gut-brain axis is a crucial interface between the central nervous system and gut microbiota. Recent evidence shows that exposure to environmental contaminants, such as heavy metals, can cause dysbiosis in microbiota, which may affect communication, impacting aspects of brain function behavior. This systematic review literature aims evaluate whether deleterious effects on due metal could be mediated by changes microbiota profile. Animal studies involving metals comparison with control group evaluated neuropsychological outcomes and/or molecular along analysis composition were reviewed. authors independently assessed for inclusion, extracted data risk bias using protocol Systematic Review Center Laboratory Experimentation (SYRCLE) preclinical studies. A search 3 databases yielded 16 eligible focused lead (n = 10), cadmium 1), mercury 3), manganese combined Pb Mn 1). animal species rats 7), mice 4), zebrafish carp 1) fruit fly Heavy found adversely cognitive function, behavior, neuronal morphology. Moreover, was associated abundance specific bacterial phyla, Firmicutes Proteobacteria, play roles health. In some studies, these alterations correlated learning memory impairments mood disorders. interplay suggests induce direct indirect through contributing neurotoxicity development However, small number papers under makes it difficult draw definitive conclusions. Further research warranted unravel underlying mechanisms translational implications human
Language: Английский
Citations
15
Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108805 - 108805
Published: June 10, 2024
The human gut microbiome, the host, and environment are inextricably linked across life course with significant health impacts. Consisting of trillions bacteria, fungi, viruses, other micro-organisms, microbiota living within our particularly dynamic responsible for digestion metabolism diverse classes ingested chemical pollutants. Exposure to pollutants not only in early but throughout growth into adulthood can alter hosts' ability absorb metabolize xenobiotics, nutrients, components critical longevity. Inflammation is a common mechanism underlying multiple environmentally related chronic conditions, including cardiovascular disease, cancer types, mental health. While growing research supports complex interactions between gaps exist. Few reviews provide descriptions mechanisms by which interact host microbiome through either direct or indirect pathways disease risk, particular focus on inflammatory pathways. This review focuses examples several commonly humans, (i) heavy metals, (ii) persistent organic (POPs), (iii) nitrates. Digestive enzymes microbes first line absorption these chemicals, have been shown compounds from less more toxic state influencing subsequent distribution excretion. In addition, may selection harmful commensal microbiota, leading dysbiosis, changes receptor-mediated signaling that integrity function intestinal tract. Arsenic, cadmium, lead (heavy metals), influence directly altering different subsequently driving inflammation metabolite production (LPS/TLR4 proteoglycan/TLR2 pathways). POPs microbial composition indirectly depending their activate key intestine (e.g., PCB-126 AHR). Nitrates nitrites' effect depend be transformed secondary tertiary metabolites bacteria. Future should continue support foundational both vitro, vivo, longitudinal population-based better identify opportunities prevention, gain additional mechanistic insights environmental translational science.
Language: Английский
Citations
13
Environmental Research, Journal Year: 2024, Volume and Issue: 250, P. 118506 - 118506
Published: Feb. 20, 2024
Language: Английский
Citations
11
Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 201, P. 105904 - 105904
Published: April 10, 2024
Language: Английский
Citations
10