Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Cells, Journal Year: 2023, Volume and Issue: 12(1), P. 184 - 184

Published: Jan. 2, 2023

Immune cells and commensal microbes in the human intestine constantly communicate with react to each other a stable environment order maintain healthy immune activities. system-microbiota cross-talk relies on complex network of pathways that sustain balance between tolerance immunogenicity. Probiotic bacteria can interact stimulate intestinal microflora modulate specific functions homeostasis. Growing evidence shows probiotic present important health-promoting immunomodulatory properties. Thus, use probiotics might represent promising approach for improving system So far, few studies have been reported beneficial modulatory effect probiotics. However, many others, which are mainly focused their metabolic/nutritional properties, published. Therefore, mechanisms behind interaction host only partially described. The review aims collect summarize most recent scientific results resulting implications how improve functions. Hence, description currently known is provided.

Language: Английский

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Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 138, P. 178 - 198

Published: June 11, 2023

The human gut hosts complex microbial communities, which are linked to health and disease. microbiota is continuously reshaped by multiple environmental factors, especially diet. Gut dysbiosis may promote various metabolic, neurological, intestinal, cardiovascular diseases, even tumor development. Probiotics have shown promising prophylactic, mitigating, or curative effects when use as nutrient supplements adjunctive therapy. These beneficial and/or symptom alleviation often accompanied microbiome metabolome changes. Differing from other published review articles, here we summarized the latest knowledge of evidence-based health-promoting probiotics scouring literature recent animal probiotic intervention studies. To elucidate mechanisms in enhancing intestinal homeostasis, barrier function, host immunity, through modulating its metabolites. Meanwhile, also discussed challenges data analysis clinical research comparison between laboratories, provides an outlook for future perspectives applications probiotics. achieved modulation. Current discussed. Finally, provided.

Language: Английский

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The role of Lactobacillus in inflammatory bowel disease: from actualities to prospects

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Sept. 29, 2023

Abstract Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease, is comprised of Ulcerative Colitis (UC) and Crohn’s (CD). IBD closely related to systemic reaction affects the progression many extraintestinal diseases. As one representative bacteria for probiotic-assisted therapy in IBD, multiple strains Lactobacillus have been proven alleviate damage strengthen immunological barrier, epithelial cell mucus barrier. also spares no effort alleviation IBD-related diseases such as Colitis-associated Colorectal cancer (CAC), Alzheimer’s (AD), Depression, Anxiety, Autoimmune Hepatitis (AIH), so on via gut-brain axis gut-liver axis. This article aims discuss role diseases, including its underlying mechanisms curative strategies from present future.

Language: Английский

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Prebiotics and Probiotics for Gastrointestinal Disorders

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 778 - 778

Published: March 9, 2024

The complex role of the gut microbiome in pathogenesis gastrointestinal (GI) disorders is an emerging area research, and there considerable interest understanding how diet can alter composition function microbiome. Prebiotics probiotics have been shown to beneficially modulate microbiome, which underlies their potential for benefit GI conditions. Formulating specific recommendations public regarding these dietary supplements has difficult due significant heterogeneity between strains, doses, duration treatment investigated across studies, as well safety concerns with administering live organisms. This review aims summarize existing evidence use prebiotics various disorders, paying special attention strain-specific effects that emerged any adverse noted.

Language: Английский

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The emerging role of the gut microbiota and its application in inflammatory bowel disease

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117302 - 117302

Published: Aug. 19, 2024

Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is a complex disorder with an unknown cause. However, the dysbiosis of gut microbiome has been found to play role in IBD etiology, exacerbated immune responses defective intestinal barrier integrity. The can also be potential biomarker for several diseases, IBD. Currently, conventional treatments targeting pro-inflammatory cytokines pathways IBD-associated do not yield effective results. Other therapies that directly target dysbiotic outcomes are emerging. We review health its as diagnostic, prognostic, therapeutic This explores emerging advancements microbiome-associated alterations IBD, such nanoparticle or encapsulation delivery, fecal microbiota transplantation, nutritional therapies, microbiome/probiotic engineering, phage therapy, mesenchymal stem cells (MSCs), proteins, herbal formulas.

Language: Английский

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Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115430 - 115430

Published: Sept. 8, 2023

Ulcerative colitis (UC) has been confirmed as a disease with high incidence and low cure rate worldwide. In severe cases, UC can develop into colon cancer. Modern research that berberine (BBR) treat by inhibiting the expressions of inflammatory factors. However, contribution gut microbiota flora metabolites in treating BBR remains unclear. this study, ameliorative effects on dysbiosis were investigated dextran sodium sulfate (DSS)-induced rodent model. We found significantly improved pathological phenotype, attenuated intestinal barrier disruption, mitigated colonic inflammation DSS mice. By 16 S rDNA sequencing, alleviated Moreover, depletion experiment therapeutic effect was inextricably correlated microbiota. Besides, (e.g., short-chain fatty acids, bile 5-hydroxytryptamine) studied using HPLC-MS. The results suggested ameliorated acid imbalance induced liver gut. Furthermore, treatment repaired damage. above revealed DSS-induced mice restoring disturbed microbiota, elevating unconjugated secondary acids gastrointestinal tract, activating FXR TGR5 signal pathway. This study provides novel insights mechanism UC.

Language: Английский

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Gut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 5, 2024

Abstract Background The gut microbiota is a critical factor in the regulation of host health, but relationship between differential resistance hosts to pathogens and interaction microbes not yet clear. Herein, we investigated potential correlation piglets their disease using single-cell transcriptomics, 16S amplicon sequencing, metagenomics, untargeted metabolomics. Results Porcine epidemic diarrhea virus (PEDV) infection leads significant changes piglets. Notably, Landrace pigs lose quickly after being infected with PEDV, transplanting fecal Min alleviated status. Macrogenomic animal protection models identified Lactobacillus reuteri amylovorus as playing an anti-infective role. Moreover, metabolomic screening secondary bile acids’ deoxycholic acid (DCA) lithocholic (LCA) correlated significantly , only LCA exerted protective function model. In addition, supplementation altered distribution intestinal T-cell populations resulted enriched CD8 + CTLs, vivo vitro experiments showed that increased SLA-I expression porcine epithelial cells via FXR receptors, thereby recruiting CTLs exert antiviral effects. Conclusions Overall, our findings indicate diversity influences development disease, manipulating well LCA, represents promising strategy improve PEDV

Language: Английский

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Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 30, 2024

Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) regulatory T cells (Tregs) produced during differentiation of CD4 + plays a key role in bone remodelling disorders RA PMOP. However, the specific mechanism this PMOP has not been clarified. Identifying underlying Th17/Treg represents factor research development new drugs for immune In review, potential roles Th17, Treg, regulating have summarised, mechanisms by which probiotics, traditional Chinese medicine compounds, monomers maintain balance expounded. maintenance could be considered as an therapeutic alternative treatment This study also summarizes advantages disadvantages conventional treatments quality life rehabilitation patients with findings presented her will provide better understanding close relationship immunity chronic diseases ideas future research, prevention,

Language: Английский

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Probiotic Bacillus licheniformis ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(1), P. 561 - 561

Published: Jan. 1, 2024

Despite Bacillus species having been extensively utilized in the food industry and biocontrol as part of probiotic preparations, limited knowledge exists regarding their impact on intestinal disorders. In this study, we investigated effect licheniformis ZW3 (ZW3), a potential isolated from camel feces, dextran sulfate sodium (DSS)-induced colitis. The results showed partially mitigated body weight loss, disease activity index (DAI), colon shortening, suppressed immune response colitis mice, evidenced by reduction levels inflammatory markers IL-1β, TNF-α, IL-6 (p < 0.05). was found to ameliorate DSS-induced dysfunction colonic barrier enhancing mucin 2 (MUC2), zonula occluden-1 (ZO-1), occludin. Furthermore, enriched beneficial bacteria Lachnospiraceae_NK4A136_group decreased harmful Escherichia-Shigella revealed that improved imbalanced gut microbiota. Abnormally elevated uric acid were further normalized upon supplementation. Overall, study emphasized protective effects mice well some applications management inflammation-related diseases.

Language: Английский

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The Potential Therapeutic Role of Lactobacillaceae rhamnosus for Treatment of Inflammatory Bowel Disease

Foods, Journal Year: 2023, Volume and Issue: 12(4), P. 692 - 692

Published: Feb. 5, 2023

Inflammatory bowel disease (IBD) is a heterogeneous group of diseases associated with chronic inflammation the intestinal tract, and highly prevalent worldwide. Although its origin not yet fully understood, new evidence emphasizes that environmental factors, especially dietary factors microbiota disorders are key triggers IBD. Probiotics, such as Lactobacillaceae spp., play an essential role in human health they exert beneficial effects on composition gastrointestinal microbial community immune system. Probiotic-based therapies have been shown to be effective alleviating Among these, rhamnosus one most widely used strains. L. present intestines healthy individuals; it regulates system reduces through variety mechanisms. The purpose this study was identify scientific related IBD, review summarize results, discuss possible mechanisms action starting point for future research IBD treatment.

Language: Английский

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