Vaginal Microbiome and the Risk of Preterm Birth in Women Living With HIV: A Scoping Review DOI
Fouzia Zahid Ali Khan, Saifuddin Ahmed, Anna Powell

et al.

American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 92(5)

Published: Oct. 30, 2024

There are sparse data on the role of vaginal microbiome (VMB) in pregnancy among pregnant women living with HIV (PWLWH) and its association spontaneous preterm birth (sPTB). We conducted a scoping review to assess associations between microbiota sPTB PWLWH. Three studies were included, representing total 180 PWLWH out 652 pregnancies. All used modern DNA sequencing methods (16S rRNA amplification, metagenomics, or metatranscriptomics). had higher VMB richness diversity compared HIV-uninfected rates two three studies. A proportion was observed those Lactobacillus-deficient, anaerobe-dominant microbiota. In studies, concentrations inflammation markers associated increased diversity. status independently sPTB. It is unclear if microbial contributes more PTB, but does appear alter individuals may also affect PTB microbiome-independent pathways. Given limited number heterogeneity sample size, collection methods, inconsistent results it difficult causally link HIV, VMB, inflammatory cytokines,

Language: Английский

The sow vaginal and gut microbiota associated with longevity and reproductive performance DOI Creative Commons
Ziyu Liu, Tsung-Cheng Tsai, Bin Zuo

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 7, 2025

Abstract Background Sow longevity and reproductivity are essential in the modern swine industry. Although many studies have focused on genetic genomic factors for selection, little is known about associations between microbiome sows with reproduction. Results In this study, we collected sequenced rectal vaginal swabs from 48 sows, nine of which completed up to four parities (U4P group), exhibiting reproductive longevity. We first identified predictors sow rectum (e.g., Akkermansia ) vagina Lactobacillus U4P group using RandomForest early breeding stage parity. Interestingly, these bacteria showed decreased predicted KEGG gene abundance involved biosynthesis amino acids. Then, tracked longitudinal changes over sows. LEfSe analysis revealed parity-associated that existed both Streptococcus Parity 1, 2, Veillonella 4). also patterns bacterial change (d 0) d 110, such as , was all parties. Furthermore, potential better performance. Finally, discovered Prevotellaceae NK3B31 total number piglets born throughout vagina. Conclusions This study highlights how reproduction within parities. The identification parity-associated, pregnancy-related, performance-correlated provides foundation targeted modulation improve animal production.

Language: Английский

Citations

1
The Vaginal Microbiota, Human Papillomavirus Infection, and Cervical Carcinogenesis: A Systematic Review in the Latina Population DOI Creative Commons

Vianney Mancilla,

Nicole R. Jimenez, Naomi Bishop

et al.

Journal of Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: 14(2), P. 480 - 497

Published: Feb. 26, 2024

Latina women experience disproportionately higher rates of HPV infection, persistence, and progression to cervical dysplasia cancer compared other racial-ethnic groups. This systematic review explores the relationship between cervicovaginal microbiome human papillomavirus dysplasia, in Latinas.

Language: Английский

Citations

7
Cervicovaginal Microbiome: Physiology, Age-Related Changes, and Protective Role Against Human Papillomavirus Infection DOI Open Access

Diana Alizhan,

Talshyn Ukybassova, Gauri Bapayeva

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1521 - 1521

Published: Feb. 24, 2025

Background/Objectives: Persistent high-risk human papillomavirus (HPV) infections are the leading cause of cervical cancer. Developing evidence suggests that cervicovaginal microbiome plays a significant role in modulating HPV persistence and progression to neoplasia. This review synthesizes current knowledge on interplay between local immunity infections, emphasizing microbial diversity, immune responses, potential therapeutic implications. Methods: A thorough literature was performed using Embase, PubMed, Scopus, Google Scholar, encompassing studies published 2000 2024. Studies examining composition microbiome, HPV-related outcomes were evaluated synthesized into comprehensive review. Results: Lactobacillus-dominant particularly with L. crispatus, creates protective environment through lactic acid production, maintenance low pH, anti-inflammatory modulation, facilitating clearance. Dysbiosis, often characterized by dominance iners overgrowth anaerobic bacteria, fosters chronic inflammation, cytokine imbalance, microenvironment conducive progression. Hormonal changes menopause exacerbate these shifts, increasing risk lesions. suggest profiles antimicrobial peptides significantly influence further infection outcomes. Conclusions: The is critical determinant outcomes, for enhance responses prevent Personalized microbiome-targeted therapies may offer novel avenue managing reducing cancer incidence.

Language: Английский

Citations

0
Urogenital colonization and pathogenicity of E. Coli in the vaginal microbiota during pregnancy DOI Creative Commons
Nassim Boutouchent, Vu Thi Ngoc Anh,

Luce Landraud

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 26, 2024

Language: Английский

Citations

3
Microbiota dynamics, metabolic and immune interactions in the cervicovaginal environment and their role in spontaneous preterm birth DOI Creative Commons
Stanley Onyango, Jia Mi, Angela Koech

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 22, 2023

Differences in the cervicovaginal microbiota are associated with spontaneous preterm birth (sPTB), a significant cause of infant morbidity and mortality. Although establishing direct causal link between sPTB remains challenging, recent advancements sequencing technologies have facilitated identification microbial markers potentially linked to sPTB. Despite variations findings, recurring observation suggests that is more diverse less stable vaginal across pregnancy trimesters. It hypothesized risk likely be modified via an intricate host-microbe interactions rather than due presence single taxon or broad community state. Nonetheless, lactobacilli dominance generally term outcomes contributes healthy environment through production lactic acid/maintenance low pH excludes other pathogenic microorganisms. Additionally, innate immunity host metabolic microbiota, such as bacteriocins use proteolytic enzymes, exerts profound influence on populations, activities, immune responses. These interplays collectively impact outcomes. This review aims summarize complexity dynamics, associations bacterial vaginosis There also consideration how probiotics may mitigate vaginosis.

Language: Английский

Citations

7
Vulvovaginitis in pregnant women DOI Creative Commons
Geraldo Duarte, Iara M. Linhares, Régis Kreitchmann

et al.

Revista Brasileira Ginecologia e Obstetrícia, Journal Year: 2024, Volume and Issue: 46

Published: Jan. 1, 2024

• The balanced vaginal microbiome is the main factor defending environment against infections. Lactobacilli play a key role in this regard, maintaining pH within normal range (3.8 to 4.5). •Hormonal and immune adaptations resulting from pregnancy influence changes during pregnancy. •An altered predisposes human immunodeficiency virus (HIV) infection. •Bacterial vaginosis clinical expression of an imbalanced microbiome. •Vulvovaginal candidiasis depends more on host's conditions than etiological agent.

Language: Английский

Citations

2
An updated study of the relationship between bacterial infections and women's immune system, focusing on bacterial compositions with successful pregnancy DOI
Raed Obaid Saleh,

Omar Dheyauldeen Salahdin,

Irfan Ahmad

et al.

Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 165, P. 104283 - 104283

Published: June 25, 2024

Language: Английский

Citations

1
Viewing Native American Cervical Cancer Disparities through the Lens of the Vaginal Microbiome: A Pilot Study DOI Creative Commons
Paweł Łaniewski, Tawnjerae R. Joe, Nicole R. Jimenez

et al.

Cancer Prevention Research, Journal Year: 2024, Volume and Issue: 17(11), P. 525 - 538

Published: Aug. 22, 2024

Abstract Vaginal dysbiosis is implicated in persistent human papillomavirus (HPV) infection and cervical cancer. Yet, there a paucity of data on the vaginal microbiome Native American communities. Here, we aimed to elucidate relationships between microbiome, HPV, sociodemographic, behavioral risk factors better understand an increased cancer women. In this pilot study, recruited 31 participants (16 15 non-Native women) Northern Arizona examined microbiota composition, HPV status, immune mediators. We also assessed individuals’ sociodemographic information physical, mental, sexual, reproductive health. Overall, profiles were dominated by common Lactobacillus species (associated with health) or mixture bacterial vaginosis–associated bacteria. Only 44% women exhibited dominance, compared 58% Women had elevated pH more frequently infected high-risk HPV. Furthermore, observed associations multiple people household, lower level education, high parity abundance specific species. Finally, dysbiotic presented levels proinflammatory cytokines. Altogether, these findings indicate interplay microbiota, host defense, which may play role disparity among Future longitudinal studies are needed determine mechanistic persistence context social determinants health toward long-term goal reducing disparities non-Hispanic White populations. Prevention Relevance: Cervical disproportionally affects Sociodemographic might contribute via alteration microbiota. show association activation, can be other racial/ethnic

Language: Английский

Citations

1
Pregnancy-Related Precancerous Cervical Lesions: Pathogenesis, Diagnosis, Evolution, and Impact upon Gestation and Fertility DOI Open Access

Teodora Ana Balan,

Raluca Bălan, Demetra Socolov

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6718 - 6718

Published: Nov. 8, 2024

More common than cervical cancer, intraepithelial neoplasia (CIN) represents a precursor lesion of carcinoma, being associated with HPV infection. Due to the bidirectional relationship between and estrogen progesterone in pregnancy, most published data claim that precancerous lesions remain stable or even regress during although several studies have indicated tendency HSILs persist. It is considered pregnancy-related undergo postpartum regression, due stimulatory effects immune microenvironment. rarity publications on this subject, we aimed offer concise overview new insights into current knowledge regarding pathogenesis, diagnosis, evolution pregnancy-associated lesions, as well their impact upon gestation fertility.

Language: Английский

Citations

1
Early prediction of preeclampsia using the first trimester vaginal microbiome DOI Creative Commons
William F. Kindschuh, George I. Austin, Yoli Meydan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Preeclampsia is a severe obstetrical syndrome which contributes to 10-15% of all maternal deaths. Although the mechanisms underlying systemic damage in preeclampsia-such as impaired placentation, endothelial dysfunction, and immune dysregulation-are well studied, initial triggers condition remain largely unknown. Furthermore, although pathogenesis preeclampsia begins early pregnancy, there are no diagnostics for this life-threatening syndrome, typically diagnosed much later, after has already manifested. Here, we performed deep metagenomic sequencing multiplex immunoassays vaginal samples collected during first trimester from 124 pregnant individuals, including 62 who developed with features. We identified multiple significant associations between factors, microbes, clinical preeclampsia. These vary BMI, stratification revealed strong

Language: Английский

Citations

1