JAC-Antimicrobial Resistance,
Journal Year:
2024,
Volume and Issue:
6(2)
Published: March 5, 2024
Abstract
Antimicrobial
resistance
surveillance
systems
have
been
established
in
China.
Two
representative
national
networks
are
the
China
Surveillance
Network
(CHINET)
and
Resistance
System
(CARSS),
both
of
which
were
2005.
For
all
clinical
isolates
collected
these
networks,
ratio
Gram-negative
bacilli
to
Gram-positive
cocci
was
approximately
7:3
during
past
18
years.
Generally,
a
higher
antimicrobial
profile
The
prevalence
ESBLs
Escherichia
coli
is
as
high
50%.
Acinetobacter
baumannii-calcoaceticus
complex
(ABC)
has
profile,
with
carbapenem
rate
66%.
However,
carbapenem-resistant
ABC
also
shown
decreasing
trend
from
2018
2022.
vancomycin-resistant
Enterococcus
low,
MRSA
Pseudomonas
aeruginosa
showed
trends
2005
CHINET
data
demonstrated
that
Klebsiella
pneumoniae
remarkable
increasing
2.9%
(imipenem
resistance)
25.0%
2018,
then
slightly
decreased
22.6%
may
reflect
stewardship
efforts
China:
professional
consensus
on
rational
use
carbapenems
issued
by
National
Health
Commission
well
implemented
nationally;
after
that,
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(9), P. 1206 - 1206
Published: Sept. 12, 2024
The
rise
of
antibiotic
resistance
and
the
dwindling
antimicrobial
pipeline
have
emerged
as
significant
threats
to
public
health.
emergence
carbapenem-resistant
hLife,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 1, 2024
The
emergence
of
hypervirulence
(hv)
and
carbapenem
resistance
(CR)
as
distinct
evolutionary
directions
for
Klebsiella
pneumoniae
presents
a
significant
threat
in
clinical
settings.
However,
recent
years,
there
has
been
growing
identification
K.
strains
that
integrate
both
phenotypes,
resulting
severe
outcomes.
Carbapenem-resistant
hypervirulent
(CRhvKP)
typically
emerges
through
the
acquisition
plasmids
carrying
either
virulence
or
CR-encoded
genes
by
carbapenem-resistant
pneumoniae.
Furthermore,
hybrid
plasmid
can
confer
combination
CR
hv.
CRhvKP
cause
variety
infections,
including
pneumonia,
urinary
tract
bloodstream
liver
abscesses,
other
related
conditions.
While
sequence
type
11
(ST11)
dominates
majority
China,
molecular
factors
responsible
success
ST11
largely
remain
unknown.
Here,
we
provide
an
overview
current
understanding
variation
distribution
crucial
determinants,
mechanisms
driving
merging
hv
CR,
potential
influencing
epidemiological
CRhvKP.
This
research
aims
to
contribute
comprehensive
complexities
surrounding
It
is
imperative
underscore
development
therapies,
precision
medicine,
vaccine
strategies
pivotal
approaches
effectively
combating
Considering
widespread
prevalence
CRhvKP,
prioritized,
multifaceted
approach
encompassing
infection
control,
active
surveillance,
innovative
therapeutics
essential.
Journal of Antimicrobial Chemotherapy,
Journal Year:
2024,
Volume and Issue:
79(9), P. 2292 - 2297
Published: July 13, 2024
Carbapenem-resistant
Klebsiella
pneumoniae
(CRKP)
is
a
major
nosocomial
infectious
pathogen
with
rapidly
increasing
prevalence.
The
genomic
epidemiological
characteristics
of
CRKP
nationwide,
especially
the
evolving
trends
within
predominant
clones,
should
be
evaluated
clearly.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 12, 2024
Abstract
Unified
strain
taxonomies
are
crucial
for
fostering
international
communication
in
microbiological
research
and
the
epidemiological
surveillance
of
bacterial
pathogens.
While
multilocus
sequence
typing
(MLST)
has
served
as
a
foundation
taxonomy
two
decades,
whole
genome
sequencing
enables
more
precise
classifications
significantly
improves
discriminatory
resolution.
The
core
genome-wide
extension
MLST
(known
cgMLST)
thus
holds
great
promise
genotyping
classification,
but
its
implementation
faces
challenges
that
include
missing
data,
potential
instability
cluster-based
nomenclatures,
necessity
to
ensure
backwards
compatibility
with
identifiers.
Life
Identification
Number
(LIN)
codes
offer
solution
by
providing
multi-level
classification
groups
inherently
stable.
Here,
we
present,
consolidate,
extend
cgMLST-based
LIN
code
approach.
We
first
develop
nicknaming
system
prefixes,
which
flexible
human-readable
nomenclatures.
Using
Klebsiella
pneumoniae
(Kp)
an
example,
nicknames
were
attributed
inheritance
from
identifiers,
perpetuating
legacy
nomenclatures
genomic
era.
show
while
7-gene
sometimes
conflates
unrelated
sublineages
into
same
ST,
highly
concordant
phylogenetic
relationships.
implement
this
novel
code-based
nomenclature
BIGSdb
platform,
illustrate,
Pathogenwatch,
how
it
can
also
be
used
other
epidemiology
platforms.
Finally,
demonstrate
value
tracking
diversity
within
high-risk
internationally
disseminated
clonal
Kp
protracted
outbreaks.
Given
stability,
precision,
flexibility,
recommend
adoption
taxonomic
approach
suggest
is
widely
applicable
One Health Advances,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: Feb. 16, 2024
Abstract
Carbapenem-resistant
Klebsiella
pneumoniae
(CRKP)
is
emerging
as
an
imminent
threat
to
worldwide
public
health
because
of
its
high
level
antimicrobial
resistance,
which
can
result
in
severe
and
challenging-to-treat
infections.
The
capsular
polysaccharide
(CPS)
bacteria
well
acknowledged
a
crucial
virulence
factor
that
shields
K.
from
the
host’s
innate
immune
system.
Polysaccharide
depolymerase,
encoded
by
bacteriophages,
hydrolyze
CPS
may
be
promising
approach
for
treating
In
this
study,
we
identified
novel
K62-type
capsule
depolymerase
(K62-Dpo30)
phage
SH-KP2492.
We
demonstrated
K62-Dpo30
could
specifically
degrade
strains
promote
susceptibility
serum
neutrophil
killing.
Furthermore,
our
findings
highlight
potential
reliable
typing
tool.
BMC Microbiology,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 6, 2025
The
infections
of
bacterial
origin
represent
a
significant
problem
to
the
public
healthcare
worldwide
both
in
clinical
and
community
settings.
Recent
decade
was
marked
by
limiting
treatment
options
for
due
growing
antimicrobial
resistance
(AMR)
acquired
transferred
various
species,
especially
ones
causing
healthcare-associated
infections,
which
has
become
dangerous
issue
noticed
World
Health
Organization.
Numerous
reports
shown
that
spread
AMR
is
often
driven
several
species-specific
lineages
usually
called
'global
clones
high
risk'.
Thus,
it
essential
track
isolates
belonging
such
investigate
mechanisms
their
pathogenicity
acquisition.
Currently,
whole
genome-based
analysis
more
used
these
purposes,
including
epidemiological
surveillance
mobile
elements
involved
transfer.
However,
spite
exponential
growth
available
genomes,
representation
lack
uniformity
availability
supporting
metadata,
creates
bottleneck
investigations.
In
this
database,
we
provide
results
thorough
genomic
61,857
genomes
highly
pathogen
Klebsiella
pneumoniae.
Important
isolate
typing
information
multilocus
sequence
(MLST)
types
(STs),
assignment
known
global
clones,
capsular
(KL)
lipooligosaccharide
(O)
types,
presence
CRISPR-Cas
systems,
cgMLST
profiles
are
given,
regarding
AMR,
virulence
genes
plasmid
replicons
within
provided.
This
database
freely
under
CC
BY-NC-SA
at
https://doi.org/10.5281/zenodo.11069018
.
will
facilitate
selection
proper
reference
sets
any
It
be
helpful
investigations
field
K.
pneumoniae
epidemiology,
as
well
development
prevention
measures
against
important
pathogen.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Ceftazidime–avibactam
(CZA)
exhibits
promising
activity
against
carbapenem-resistant
Klebsiella
pneumoniae
(CRKP).
However,
CZA-resistant
CRKP
(CRKPCZA−R)
strains
have
been
emerging.
This
study
explored
the
mechanism
underlying
CZA
resistance
in
these
strains.
CRKPCZA−R
was
screened
from
non-repetitive
at
our
hospital
January
1,
2018
to
October
30,
2021.
The
drug
and
homology
were
analyzed
through
carbapenemase
phenotype
detection
next-generation
sequencing.
In
total,
67
of
623
isolates
(10.8%)
CRKPCZA−R.
most
prevalent
resistant
genes
blaNDM−1
(44.8%,
30/67),
followed
by
blaIMP−4
(9.0%,
6/67),
blaNDM−5
(7.5%,
5/67),
blaNDM−4
(1.5%,
1/67).
Furthermore,
37.3%
(25/67)
simultaneously
harbored
more
than
two
carbapenemase-encoding
genes.
enzyme
inhibitor
enhancement
method
detected
with
high
sensitivity
(82.1%),
particularly
for
harboring
a
single
(100%).
presence
or
limited
its
ability.
Notably,
21
ST11-KL64
exhibiting
blaNDM−1,
blaKPC−2,
also
ompk36
deletion,
17
co-carried
virulence
gene
markers,
suggesting
clonal
transmission.
Patients
infected
older
serious
other
drug-resistant
strains,
which
higher
MIC50
fosfomycin
conclusion,
rate
relatively
high,
could
be
attributed
transmission
MBL
Although
can
detect
carbapenemases
specificity,
it
might
ability
that
produce
carbapenemases.
both
blaKPC−2
should
closely
monitored.
