Consensus on COVID-19 vaccine recommendations: Challenges and strategies for high-risk populations in Taiwan DOI Creative Commons
Chih‐Hsing Wu, Wei‐Chieh Hung, Chun‐Feng Huang

et al.

Journal of the Formosan Medical Association, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

The COVID-19 pandemic has had a profound impact globally, particularly in high-risk populations such as those with underlying health conditions. In response to the evolving landscape and recent surge confirmed cases Taiwan, Taiwan Association of Family Medicine (TAFM) established consensus on vaccine recommendations for vulnerable groups through comprehensive literature review, expert panel discussions, practice-oriented formulation procedure develop evidence-based guidance. Its key findings highlight increased risk severe outcomes among individuals disorders diabetes, obesity, chronic kidney disease, cardiovascular respiratory illness. It emphasizes safety effectiveness vaccines, mRNA these populations. underscores critical role family medicine physicians response, including routine screening, education, vaccination delivery, continuous research optimize strategies. Ongoing monitoring, adaptation, collaborative efforts will be essential ensure continued landscape. conclusion, TAFM provide robust framework guide healthcare providers policymakers tailoring address unique needs are an applicable template neighboring countries.

Language: Английский

Comparative Effectiveness of the Bivalent (Original/Omicron BA.4/BA.5) mRNA COVID-19 Vaccines mRNA-1273.222 and BNT162b2 Bivalent in Adults with Underlying Medical Conditions in the United States DOI Creative Commons

Hagit Kopel,

Văn Hùng Nguyễn, Alina Bogdanov

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(10), P. 1107 - 1107

Published: Sept. 27, 2024

This retrospective cohort study evaluated the relative vaccine effectiveness (rVE) of two bivalent (original/Omicron BA.4/BA.5) vaccines mRNA-1273.222 versus BNT162b2 Bivalent in preventing COVID-19-related outcomes adults with underlying medical conditions associated increased risk for severe COVID-19.

Language: Английский

Citations

5
Prophylactic vaccination strategies for adult patients with diabetes: a narrative review of safety profiles and clinical effectiveness DOI Creative Commons
Olivia Cicilia Walewangko,

Jonathan Suciono Purnomo,

Pranasha Amabella Jo

et al.

Clinical and Experimental Vaccine Research, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 1, 2025

Language: Английский

Citations

0
COVID-19 Vaccine Effectiveness and Risk Factors of Booster Failure in 480,000 Patients with Diabetes Mellitus: A Population-Based Cohort Study DOI Creative Commons
Maria Christina L. Oliveira, Daniella Reis Barbosa Martelli, Ana Cristina Simões e Silva

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 979 - 979

Published: April 24, 2025

To investigate the real-world effectiveness of COVID-19 vaccines in a large cohort patients with diabetes mellitus (DM), we analyzed all >18-year-old registered Brazilian nationwide surveillance database between February 2020 and 2023. The primary outcome interest was vaccine against death, evaluated using multivariate logistic regression models. Among 2,131,089 SIVEP-Gripe, 482,677 (22.6%) had DM. After adjusting for covariates, DM higher risk death than those without comorbidities (adjusted odds ratio [aOR] = 1.43, 95% CI, 1.39–1.47). For (72.7%, 70.5–74.7) (73.4%, 68.2–76.7), similar after booster dose. However, it reduced associated other (60.5%; 57.5–63.2). strongest factor failure omicron variant (aOR 27.8, 19.9–40.1). Our study revealed that provided robust protection individuals our findings underscore need to update develop tailored strategies diabetes, especially additional underlying conditions.

Language: Английский

Citations

0
The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19 DOI Open Access
Adam Drzymała

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9635 - 9635

Published: Sept. 5, 2024

Angiotensin-converting enzyme 2 (ACE2) is considered a severe acute respiratory syndrome coronavirus (SARS-CoV-2) receptor of high importance, but due to its non-ubiquitous expression, studies other proteins that may participate in virus internalisation have been undertaken. To date, many alternative receptors discovered. Their functioning provide an explanation for some the events observed COVID-19 cannot be directly explained by model which ACE2 constitutes central point infection. Diabetes mellitus type (T2D) can induce development. Although mechanisms associated with lead increased SARS-CoV-2 virulence diabetes, such as basigin (CD147), glucose-regulated protein 78 kDa (GRP78), cluster differentiation 4 (CD4), transferrin (TfR), integrins α5β1/αvβ3, or co-receptors neuropilin (NRP2), vimentin, and even syalilated gangliosides also responsible worsening course. On hand, others play protective roles. Understanding how diabetes-associated via modification needs further extensive studies.

Language: Английский

Citations

3
Factors Predicting COVID-19 Vaccine Effectiveness and Longevity of Humoral Immune Responses DOI Creative Commons
Engin Berber, Ted M. Ross

Vaccines, Journal Year: 2024, Volume and Issue: 12(11), P. 1284 - 1284

Published: Nov. 15, 2024

The COVID-19 pandemic, caused by SARS-CoV-2, prompted global efforts to develop vaccines control the disease. Various vaccines, including mRNA (BNT162b2, mRNA-1273), adenoviral vector (ChAdOx1, Ad26.COV2.S), and inactivated virus platforms (BBIBP-CorV, CoronaVac), elicit high-titer, protective antibodies against virus, but long-term antibody durability effectiveness vary. objective of this study is elucidate factors that influence vaccine (VE) longevity humoral immune responses through a review relevant literature, clinical real-world studies. Here, we discuss response different identify influencing VE longevity. Despite initial robust responses, vaccine-induced immunity wanes over time, particularly with emergence variants, such as Delta Omicron, exhibit escape mechanisms. Additionally, elicited platforms, along identification essential determinants protection-like pre-existing immunity, booster doses, hybrid demographic factors-are critical for protecting severe COVID-19. Booster vaccinations substantially restore neutralizing levels, especially immune-evasive while individuals have more durable potent response. Importantly, comorbidities diabetes, cardiovascular disease, chronic kidney cancer significantly reduce magnitude protection. Immunocompromised individuals, those undergoing chemotherapy hematologic malignancies, diminished benefit disproportionately from vaccinations. Age sex also older adults experiencing accelerated decline females generally exhibiting stronger compared males. Understanding variables affecting protection crucial improving strategies predicting

Language: Английский

Citations

2
Comparative Effectiveness of the Bivalent (Original/Omicron BA.4/BA.5) mRNA COVID-19 Vaccines mRNA-1273.222 and BNT162b2 Bivalent in Adults With Underlying Medical Conditions in the United States DOI Open Access

Hagit Kopel,

Văn Hùng Nguyễn, Alina Bogdanov

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 7, 2024

Abstract This retrospective cohort study evaluated the relative vaccine effectiveness (rVE) of two bivalent (Original/Omicron BA.4/BA.5) vaccines mRNA-1273.222 versus BNT162b2 Bivalent in preventing COVID-19-related outcomes adults with underlying medical conditions associated increased risk for severe COVID-19. In a linked EHR-claims dataset, US (≥18 years) ≥1 condition interest who received either between August 31, 2022, and February 28, 2023, were identified. Inverse probability treatment weighting was used to adjust differences. Cohorts followed up hospitalizations outpatient encounters until May 2023. Hazard ratios rVEs estimated using Cox regression. Subgroup analyses performed on individuals pre-specified comorbid conditions. 757,572 1,204,975 recipients The adjusted rVE over median follow-up 198 days 10.9% (6.2%-15.2%) against hospitalization 3.2% (1.7%-4.7%) encounters. estimates COVID-19 among subgroups were: diabetes 15.1% (8.7%–21.0%), cardiovascular disease 14.7% (9.0%–20.1%), chronic lung 11.9% (5.1%–18.2%), immunocompromised 15.0% (7.2%–22.2%), kidney 8.4% (0.5%–15.7%). Overall, conditions, more effective than Bivalent, especially hospitalizations.

Language: Английский

Citations

1
Exploring the associations between gut microbiota composition and SARS-CoV-2 inactivated vaccine response in mice with type 2 diabetes mellitus DOI Creative Commons
Long Liu,

Xianzhen He,

Jiaqi Wang

et al.

mSphere, Journal Year: 2024, Volume and Issue: 9(9)

Published: Aug. 27, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is crucial for protecting vulnerable individuals, yet individuals with type diabetes mellitus (T2DM) often exhibit impaired vaccine responses. Emerging evidence suggests that the composition of host microbiota, in immune regulation and development, influences efficacy. This study aimed to characterize relationships between SARS-CoV-2 inactivated microbiota (specifically, gut lung microbiota) C57BL/6 mice T2DM. Employing 16S rRNA metagenomic sequencing ultra-high-performance liquid chromatography-mass spectrometry, we observed lower alpha diversity distinct beta fecal before 28 days post-vaccination T2DM healthy mice. Compared mice, showed a higher Firmicutes/Bacteroidetes ratio post-vaccination. Significant alterations were detected following vaccination, while remained unchanged. was associated diminished initial IgG antibody response against spike protein, which subsequently normalized after days. Notably, positively correlated pre-vaccination. Furthermore, days, increased relative abundance probiotics (

Language: Английский

Citations

1
Consensus on COVID-19 vaccine recommendations: Challenges and strategies for high-risk populations in Taiwan DOI Creative Commons
Chih‐Hsing Wu, Wei‐Chieh Hung, Chun‐Feng Huang

et al.

Journal of the Formosan Medical Association, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

The COVID-19 pandemic has had a profound impact globally, particularly in high-risk populations such as those with underlying health conditions. In response to the evolving landscape and recent surge confirmed cases Taiwan, Taiwan Association of Family Medicine (TAFM) established consensus on vaccine recommendations for vulnerable groups through comprehensive literature review, expert panel discussions, practice-oriented formulation procedure develop evidence-based guidance. Its key findings highlight increased risk severe outcomes among individuals disorders diabetes, obesity, chronic kidney disease, cardiovascular respiratory illness. It emphasizes safety effectiveness vaccines, mRNA these populations. underscores critical role family medicine physicians response, including routine screening, education, vaccination delivery, continuous research optimize strategies. Ongoing monitoring, adaptation, collaborative efforts will be essential ensure continued landscape. conclusion, TAFM provide robust framework guide healthcare providers policymakers tailoring address unique needs are an applicable template neighboring countries.

Language: Английский

Citations

0