Short-chain fatty acids: linking diet, the microbiome and immunity

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(8), P. 577 - 595

Published: April 2, 2024

Language: Английский

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Inflammation and malnutrition in inflammatory bowel disease

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2023, Volume and Issue: 8(6), P. 579 - 590

Published: March 15, 2023

Language: Английский

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Inflammatory Bowel Diseases and Gut Microbiota

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3817 - 3817

Published: Feb. 14, 2023

Inflammatory bowel disease (IBD) is an inflammatory of the gastrointestinal tract, incidence which has rapidly increased worldwide, especially in developing and Western countries. Recent research suggested that genetic factors, environment, microbiota, immune responses are involved pathogenesis; however, underlying causes IBD unclear. Recently, gut microbiota dysbiosis, a decrease abundance diversity specific genera, been as trigger for IBD-initiating events. Improving identifying bacterial species essential understanding pathogenesis treatment autoimmune diseases. Here, we review different aspects role played by provide theoretical basis modulating through probiotics, fecal transplantation, microbial metabolites.

Language: Английский

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Oxidative Stress, Inflammation, Gut Dysbiosis: What Can Polyphenols Do in Inflammatory Bowel Disease?

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 967 - 967

Published: April 20, 2023

Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted associated with oxidative stress, unbalanced gut microbiota, aberrant immune response. Indeed, stress can affect the progression development by regulating homeostasis microbiota Therefore, redox-targeted therapy promising treatment option for IBD. Recent evidence has verified that Chinese herbal medicine (CHM)-derived polyphenols, natural antioxidants, able to maintain redox equilibrium in tract prevent abnormal radical responses. Here, we provide comprehensive perspective implementing antioxidants as potential candidate medications. In addition, demonstrate novel technologies stratagems promoting antioxidative properties CHM-derived including delivery systems, chemical modifications, combination strategies.

Language: Английский

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Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications

Life, Journal Year: 2024, Volume and Issue: 14(5), P. 559 - 559

Published: April 26, 2024

The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as the gut microbiota, which play a pivotal role in breaking down undigested foods, such dietary fibers. Through fermentation these food components, short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced, offering numerous health benefits host. production absorption SCFAs occur through various mechanisms within human intestine, contingent upon types fibers reaching specific engaged fermentation. Medical literature extensively documents supplementation SCFAs, particularly butyrate, treatment gastrointestinal, metabolic, cardiovascular, gut-brain-related disorders. This review seeks provide an overview dynamics involved gut. Additionally, it will focus on roles promoting metabolic health, well their current therapeutic implications.

Language: Английский

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Association between dietary inflammatory index and Stroke in the US population: evidence from NHANES 1999–2018

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 2, 2024

Abstract Background There is an increasing awareness that diet-related inflammation may have impact on the stroke. Herein, our goal was to decipher association of dietary inflammatory index (DII) with stroke in US general population. Methods We collected cross-sectional data 44,019 participants National Health and Nutrition Examination Survey (NHANES) 1999–2018. The DII estimated using weighted multivariate logistic regression, its nonlinearity being examined by restricted cubic spline (RCS) regression. least absolute shrinkage selection operator (LASSO) regression applied for identifying key stroke-related factors, which then included establishment a risk prediction nomogram model, receiver operating characteristic (ROC) curve built evaluate discriminatory power Results After confounder adjustment, adjusted odds ratios (ORs) 95% confidence intervals (CIs) across higher quartiles were 1.19 (0.94–1.54), 1.46 (1.16–1.84), 1.87 (1.53–2.29) compared lowest quartile, respectively. RCS showed nonlinear positive between model based factors identified LASSO displayed considerable predicative value stroke, area under (AUC) 79.8% (78.2–80.1%). Conclusions Our study determined Given intrinsic limitations design, it necessary conduct more research ensure causality such association.

Language: Английский

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The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 25, 2024

Abstract Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the bacterial configuration disturbs this microbe-mucus interaction, but specific microbial metabolites responsible maintaining remain poorly understood. By using human-to-mouse microbiota transplantation ex vivo analysis of function, we here show as a proof-of-concept that individuals who increase their daily dietary fiber intake can improve capacity to prevent diet-mediated defects. Mucus growth, critical feature intact mucus, correlated with abundance commensal Blautia , supplementation coccoides mice confirmed mucus-stimulating capacity. Mechanistically, B. stimulated growth through production short-chain fatty acids propionate acetate via activation acid receptor Ffar2, which could serve new target restore during mucus-associated lifestyle diseases.

Language: Английский

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Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(5), P. 661 - 675.e10

Published: April 23, 2024

Language: Английский

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Heavy arch: from inflammatory bowel diseases to metabolic disorders

Gut, Journal Year: 2024, Volume and Issue: 73(8), P. 1376 - 1387

Published: May 22, 2024

Background Metabolic disorders and inflammatory bowel diseases (IBD) have captured the globe during Westernisation of lifestyle related dietary habits over last decades. Both disease entities are characterised by complex heterogeneous clinical spectra linked to distinct symptoms organ systems which, on a first glimpse, do not many commonalities in practice. However, experimental studies indicate common backbone mechanisms metabolic gut inflammation, emerging evidence suggests an intricate interplay between IBD. Objective We depict parallels IBD diseases, easily overlooked routine. Design provide overview recent literature discuss implications morbidity patients with for researchers, clinicians healthcare providers. Conclusion The Western diet microbial perturbation serve as fuel inflammation beyond gut. syndrome increasingly affect IBD, expected negative impact both risk complications. This concept implies that tackling obesity pandemic exerts beneficial effects health.

Language: Английский

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Advanced Glycation End-Products and Their Effects on Gut Health

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 405 - 405

Published: Jan. 13, 2023

Dietary advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed when reducing sugars heated with proteins, amino acids, or lipids at high temperatures for prolonged period. The presence and accumulation AGEs in numerous cell types tissues known to be prevalent the pathology many diseases. Modern diets, which contain proportion processed foods therefore level AGE, cause deleterious effects leading multitude unregulated intracellular extracellular signalling inflammatory pathways. Currently, studies focus on investigating chemical structural aspects how they affect metabolism cardiovascular renal systems. Studies have also shown that digestive system. However, there is no complete picture implication this area. gastrointestinal tract not only first principal site digestion absorption dietary but one most susceptible organs AGEs, may exert local systemic effects. In review, we summarise current evidence association between high-AGE diet poor health outcomes, special relationship alterations structure, modifications enteric neurons, microbiota reshaping.

Language: Английский

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