DELETED, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 4, 2024
Language: Английский
Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1772 - 1772
Published: July 7, 2023
Desulfovibrio (DSV) are sulfate-reducing bacteria (SRB) that ubiquitously present in the environment and as resident commensal within human gastrointestinal tract. Though they minor residents of healthy gut, DSV opportunistic pathobionts may overgrow setting various intestinal extra-intestinal diseases. An increasing number studies have demonstrated a positive correlation between overgrowth (bloom) While relationship bloom disease pathology has not been clearly established, mounting evidence suggests causal role for these development. As most predominant genera SRB this review summarizes current knowledge regarding variety In study, we also discuss mechanisms by which contribute to pathology.
Language: Английский
Citations
91
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9605 - 9605
Published: May 31, 2023
S100B is a calcium-binding protein mainly concentrated in astrocytes the nervous system. Its levels biological fluids are recognized as reliable biomarker of active neural distress, and more recently, mounting evidence points to Damage-Associated Molecular Pattern molecule, which, at high concentration, triggers tissue reactions damage. and/or distribution patients experimental models different disorders, for which used biomarker, directly related progress disease. In addition, diseases such Alzheimer’s Parkinson’s diseases, amyotrophic lateral sclerosis, multiple traumatic vascular acute injury, epilepsy, inflammatory bowel disease, alteration correlates with occurrence clinical toxic parameters. general, overexpression/administration worsens presentation, whereas deletion/inactivation contributes amelioration symptoms. Thus, may be proposed common pathogenic factor sharing symptoms etiologies but appearing share some processes reasonably attributable neuroinflammation.
Language: Английский
Citations
54
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: July 15, 2024
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition that affects the digestive system and includes Crohn’s (CD) ulcerative colitis (UC). Although exact etiology of IBD remains uncertain, dysfunctional immunoregulation gut believed to be main culprit. Amongst immunoregulatory factors, reactive oxygen species (ROS) nitrogen (RNS), components oxidative stress event, are produced at abnormally high levels in IBD. Their destructive effects may contribute disease’s initiation propagation, as they damage lining activate inflammatory signaling pathways, further exacerbating inflammation. Oxidative markers, such malondialdehyde (MDA), 8-hydroxy-2’-deoxyguanosine (8-OHdG), serum-free thiols (R-SH), can measured blood stool patients with These markers elevated IBD, their correlate severity disease. Thus, used not only diagnosis but also monitoring response treatment. It targeted treatment through use antioxidants, including vitamin C, E, glutathione, N-acetylcysteine. In this review, we summarize role pathophysiology its diagnostic targets, potential application antioxidant therapies manage treat
Language: Английский
Citations
31
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 117956 - 117956
Published: Feb. 29, 2024
Language: Английский
Citations
19
Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Language: Английский
Citations
8
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 4, 2025
Ulcerative colitis is an idiopathic gastrointestinal disease described by chronic inflammation of the digestive system. Cytokines may be responsible for immunopathogenesis, mucosal and tissue damage, even treatment response. In addition to its role in calcium phosphorus homeostasis bone health, vitamin D immunomodulatory anti-inflammatory agent. Understanding cytokines lead improving pathogenesis this disease, therefore we aimed investigate relative gene expression pro- biopsy samples taken from affected area colon ulcerative patients association with serum levels. A total 47 were enrolled case-control study. The case group consisted 23 treatment-resistant colitis, control 24 responding routine treatment. Serum levels measured ELISA method. Real-time PCR was employed quantify groups. pro-inflammatory included tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), interleukin-1β (IL-1β), IL-6, IL-8, IL-17 A, IL-33, while IL-10, IL-35, TGF-β. Data are showed as mean ± standard deviation (SD), p values < 0.05 considered statistically significant. age 45.88 18.51 years, that 41.30 13.01 years. TNF-α, IFN-γ, IL-1β, TGF-β, groups did not exhibit significant differences (p > 0.05). However, principal cytokines, including elevated compared who responded treatments. No correlation observed between present study identify a or Therefore, treatments had no effect on these patients. Additionally, related Despite need further research protective pathological roles D, regular screening early complementary beneficial reducing inflammatory symptoms
Language: Английский
Citations
2
Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 15, 2024
Language: Английский
Citations
16
Applied Materials Today, Journal Year: 2024, Volume and Issue: 36, P. 102078 - 102078
Published: Jan. 20, 2024
Language: Английский
Citations
9
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4940 - 4940
Published: June 6, 2024
Cynara scolymus L. is an herbaceous plant originally from the western Mediterranean area, with Italy, Spain and France main being producers. Both edible flowering head by-products generated during processing (outer bracts, leaves stem) are characterized by a high content of essential vitamins, minerals bioactive compounds. In particular, represent great source phenolic acids derived caffeoylquinic acid or flavonoids such as luteonin apigenin, while stem contain soluble insoluble dietary fiber, especially inulin pectins. Its compounds provides artichoke antioxidant power due to modulation effect transcription factor Nrf2, which may lead protection against cardiovascular, hepatic neurological disorders. The potential use functional ingredient in food industry be promising terms improving nutritional value products, well preventing oxidation extending shelf-life processed foods its antimicrobial activity. This review aims provide overview qualities by-products, focusing on possible health effects applications products higher-value-added alternative ingredient.
Language: Английский
Citations
9
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: Oct. 4, 2023
The microbiota gut brain (MGB) axis has been shown to play a significant role in the regulation of inflammatory and infective diseases. Exploring structure communication mode MGB is crucial for understanding its diseases, studying signaling pathways regulatory methods diseases also profound significance future clinical research. This article reviews composition, mechanism including Parkinson’s disease (PD), Alzheimer’s (AD), multiple sclerosis (MS), autism spectrum disorder (ASD), depression, psoriasis, irritable bowel syndrome (IBS), (IBD). In addition, our investigation delved into functions inflammasome, IFN-I, NF-κB, PARK7/DJ-1 innate immune pathway context Ultimately, we discussed efficacy various interventions, fecal transplantation (FMT), antibiotics, probiotics, prebiotics, synbiotics, postbiotics, management Understanding might make positive effects treatment
Language: Английский
Citations
21