Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges DOI Creative Commons
Qin Dang, Lulu Zuo, Xinru Hu

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(14)

Published: July 1, 2024

Abstract Background Colorectal cancer (CRC) is among the most hackneyed malignancies. Even patients with identical clinical symptoms and same TNM stage still exhibit radically different outcomes after receiving equivalent treatment regimens, indicating extensive heterogeneity of CRC. Myriad molecular subtypes CRC have been exploited for decades, including compelling consensus subtype (CMS) classification that has broadly applied patient stratification biomarker‐drug combination formulation. Encountering barriers to translation, however, CMS fails fully reflect inter‐ or intra‐tumor As a consequence, addressing precisely managing unique characteristics remain arduous tasks clinicians. Review In this review, we systematically summarize further elaborate on their applications, limitations, future orientations. Conclusion recent years, exploration through cell lines, animal models, patient‐derived xenografts (PDXs), organoids, trials contributes refining biological insights unraveling subtype‐specific therapies in Therapeutic interventions nanotechnology, clustered regulatory interspaced short palindromic repeat/CRISPR‐associated nuclease 9 (CRISPR/Cas9), gut microbiome, liquid biopsy are powerful tools possibility shift immunologic landscape outlook precise medicine.

Language: Английский

Tertiary lymphoid structures in cancer: immune mechanisms and clinical implications DOI Creative Commons
Siyu Wang, Hua Wang,

Chenbei Li

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(3)

Published: March 1, 2024

Abstract Cancer is a major cause of death globally, and traditional treatments often have limited efficacy adverse effects. Immunotherapy has shown promise in various malignancies but less effective tumors with low immunogenicity or immunosuppressive microenvironment, especially sarcomas. Tertiary lymphoid structures (TLSs) been associated favorable response to immunotherapy improved survival cancer patients. However, the immunological mechanisms clinical significance TLS malignant are not fully understood. In this review, we elucidate composition, neogenesis, immune characteristics tumors, as well inflammatory development. An in‐depth discussion unique TLSs lung cancer, breast melanoma, soft tissue sarcomas will be presented. Additionally, therapeutic implications TLS, including its role marker prognosis, strategies promote formation maturation explored. Overall, aim provide comprehensive understanding tumor microenvironment suggest potential interventions for treatment.

Language: Английский

Citations

5
Prediction values of tertiary lymphoid structures in the prognosis of patients with left- and right-sided colon cancer: a multicenter propensity score-matched study DOI Creative Commons

Yonghuan Mao,

Xingzhou Wang,

Ling Xi

et al.

International Journal of Surgery, Journal Year: 2023, Volume and Issue: unknown

Published: May 29, 2023

Tertiary lymphoid structures (TLS) are the lymphocyte aggregates that play a key role in vast majority of solid tumors including colon cancer, displaying an antitumor effect under most circumstances. The heterogeneity between left- and right-sided cancer (LCC RCC) encompasses various aspects, such as clinical manifestations, pathological features, immune responses. However, function prognostic significance TLS within LCC RCC have yet to be fully understood.A retrospective analysis was performed on 2612 patients who underwent radical resection for or without distant metastasis multiple medical centers. Utilizing propensity score matching, 121 with were selected training set. An external validation set 64 also employed. Hematoxylin-eosin immunohistochemical staining used assess proportion cells. Clinical characteristics values analyzed. Nomograms constructed predict 3-year 5-year overall survival (OS), respectively.For patients, located interstitial region outside tumor tissue mainly consisted B cells T quantity density higher than those LCC. In multivariate Cox regression analysis, ( P =0.014), vascular invasion =0.019), AJCC stage =0.026) independent factors OS RCC. For =0.024), differentiation =0.001), budding =0.040) emerged OS. Similar results obtained verification Separate nomograms developed, improved prediction performance compared 8th edition TNM staging system.Differences observed RCC, suggesting nomogram based could more effectively patients. Furthermore, recommended better patient survival. Taken together, these suggested at left right side substantially different, which may lead use different model development individual treatment strategy.

Language: Английский

Citations

12
Mapping the intellectual structure and landscape of colorectal cancer immunotherapy: A bibliometric analysis DOI Creative Commons

Qin Ling Ou,

Yong Long Chang,

Jin Hui Liu

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: March 18, 2024

Immunotherapy, particularly immune checkpoint inhibitor (ICIs) therapy, stands as an innovative therapeutic approach currently garnering substantial attention in cancer treatment. It has become a focal point of numerous studies, showcasing significant potential treating malignancies, including lung and melanoma. The objective this research is to analyze publications regarding immunotherapy for colorectal (CRC), investigating their attributes identifying the current areas interest cutting-edge advancements. We took into account from 2002 2022 included Web Science Core Collection. Bibliometric analysis visualization were conducted using CiteSpace, VOSviewer, R-bibliometrix, Microsoft Excel. quantity associated with domain been steadily rising over years, encompassing 3753 articles 1498 reviews originating 573 countries regions, involving 19,166 institutions, 1011 journals, 32,301 authors. In field, China, United States, Italy are main that come forward publishing. journal greatest impact factor CA-A Cancer Journal Clinicians. Romain Cohen leads number publications, while Le Dt out most influential author. microenvironment infiltration emerging key hotspots future directions domain. This carries extensive bibliometric examination cancer, aiding researchers understanding points, possible avenues research, recognizing forthcoming development trends.

Language: Английский

Citations

4
Tertiary lymphoid structures: new immunotherapy biomarker DOI Creative Commons
Fangyuan Yang,

Jiahe Yang,

Meijuan Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 4, 2024

Immunotherapy shows substantial advancement in cancer and is becoming widely used clinical practice. A variety of biomarkers have been proposed to predict the efficacy immunotherapy, but most them low predictive ability. Tertiary lymphoid structures (TLSs), aggregation multiple lymphocytes, found exist various tumor tissues. TLSs shown correlate with patient prognosis immunotherapy response. This review summarizes characteristics inducing factors TLS formation, presents available evidence on role predicting response different cancers, lastly emphasizes their potential for neoadjuvant efficacy.

Language: Английский

Citations

4
Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies DOI Creative Commons
Chang Zhu,

J Liao,

Yiyang Liu

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 14, 2024

Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout process liver formation, immune cells play pivotal role, particularly pre-metastatic and metastatic niches within liver. Immune establish extensive intricate interactions with tumor other components liver, collectively promoting sustaining growth metastases. Despite limited efficacy existing therapeutic modalities against some metastases, novel immune-based treatment approaches continuously being explored validated. Building on systematic elucidation immunosuppressive characteristics we potential immunotherapies applicable to patients from multiple dimensions.

Language: Английский

Citations

4
Immunogenicity of mesenchymal stromal/stem cells DOI Open Access
Wenyan Chen, Lu Lv, Na Chen

et al.

Scandinavian Journal of Immunology, Journal Year: 2023, Volume and Issue: 97(6)

Published: March 25, 2023

Mesenchymal stromal/stem cells (MSCs) possess the ability to self-renew and differentiate into other cell types. Because of their anti-inflammatory immunomodulatory abilities, as well more ready availability compared stem sources, MSCs hold great promise for treatment many diseases, such haematological defects, acute respiratory distress syndrome, autoimmunity, cardiovascular etc. However, immune rejection remains an important problem. are considered have low immunogenicity, but they do not full immunological privilege. This review analyzes discusses safety from perspective with aim providing a reference future research clinical application.

Language: Английский

Citations

10
Heterogeneity of tertiary lymphoid structures in cancer DOI Creative Commons
Xin You, Kristina Koop, Andreas Weigert

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 4, 2023

The success of immunotherapy approaches, such as immune checkpoint blockade and cellular with genetically modified lymphocytes, has firmly embedded the system in roadmap for combating cancer. Unfortunately, majority cancer patients do not yet benefit from these therapeutic even when prognostic relevance response their tumor entity been demonstrated. Therefore, there is a justified need to explore new strategies inducing anti-tumor immunity. recent connection between formation ectopic lymphoid aggregates at sites patient prognosis, along an effective response, suggests that manipulating occurrence tertiary structures (TLS) may play critical role activating against growing tumor. However, mechanisms governing TLS clear understanding substantial heterogeneity are still lacking. Here, we briefly summarize current state knowledge regarding driving development, outline impact on clinical outcomes patients, discuss appropriate systems modeling help identify protective patients.

Language: Английский

Citations

10
Impact of lymph node metastasis on immune microenvironment and prognosis in colorectal cancer liver metastasis: insights from multiomics profiling DOI Creative Commons
Yueyang Zhang, Deng Wu, Zhen Zhang

et al.

British Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Background This study aimed to investigate the prognostic impact of lymph node metastasis (LNM) on patients with colorectal cancer liver (CRLM) and elucidate underlying immune mechanisms using multiomics profiling. Methods We enrolled CRLM from US Surveillance, Epidemiology, End Results (SEER) cohort a multicenter Chinese cohort, integrating bulk RNA sequencing, single-cell sequencing proteomics data. The cancer-specific survival (CSS) profiles tumor-draining nodes (TDLNs), primary tumors were compared between without LNM. Pathological evaluations used assess cell infiltration histological features. LNM had significantly shorter CSS than in two large cohorts. Our results showed that nonmetastatic TDLNs exhibited greater abundance cells, including CD4+ T CD8+ CD19+ B whereas metastatic enriched fibroblasts, endothelial macrophages. Immunohistochemical analysis confirmed elevated levels CD3+ cells TDLNs. presence was associated enhanced antitumor responses tumors, characterized by higher Klintrup–Makinen (KM) grade tertiary lymphoid structures. Furthermore, predominantly desmoplastic growth pattern (dHGP), while those replacement (rHGP). Conclusions research highlights adverse reveals potential related through analysis. paves way for further refinement AJCC TNM staging system clinical practice.

Language: Английский

Citations

0
Tertiary Lymphoid Structures as a Biomarker in Immunotherapy and Beyond: Advancing Towards Clinical Application DOI Creative Commons

Xinyu Cui,

Xuanyu Gu,

Dongyu Li

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217491 - 217491

Published: Jan. 1, 2025

Language: Английский

Citations

0
Determining the status of tertiary lymphoid structures in invasive pulmonary adenocarcinoma based on chest CT radiomic features DOI Creative Commons
Ye Yu, Tianshu Yang, Pengfei Ma

et al.

Insights into Imaging, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 29, 2025

Abstract Objectives The aim of this study was to determine the status tertiary lymphoid structures (TLSs) using radiomic features in patients with invasive pulmonary adenocarcinoma (IA). Methods In retrospective study, IA from November 2015 March 2024 were recruited two independent centers (center 1, training and internal test data set; center 2, external set). TLS divided into groups according hematoxylin-eosin staining. Radiomic extracted, support vector machine (SVM) implemented predict TLSs. Receiver operating characteristic (ROC) curves used analyze diagnostic performance. Furthermore, visual assessments set also conducted by thoracic radiologists compared radiomics results. Results A total 456 included (training set, n = 278; 115; 63). area under curve (AUC) model on validation 0.781 (95% confidence interval (CI): 0.659–0.905;), 0.804 CI: 0.723–0.884;) 0.747 0.621–0.874;), respectively. assessments, mean CT value air bronchogram important indicators TLS, AUC 0.683. clinical 0.632. Conclusions has a higher than effectively discriminates TLSs IA. Critical relevance statement This demonstrates that radiomics-based can differentiate As non-invasive biomarker, it enhances our understanding tumor prognosis management. Key Points are closely related favorable outcomes non-small cell lung cancer. Radiomics Chest predicted supports individualized decision-making for Graphical

Language: Английский

Citations

0