Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: April 26, 2024
The study investigates morphological variants of tertiary lymphoid structures (TLSs) in relation to cervical cancer development, from intraepithelial neoplastic lesions invasive carcinomas with locoregional lymph node metastases.
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Aug. 28, 2024
Tertiary lymphoid structures (TLSs) are defined as aggregates formed in non-hematopoietic organs under pathological conditions. Similar to secondary (SLOs), the formation of TLSs relies on interaction between tissue inducer (LTi) cells and organizer (LTo) cells, involving multiple cytokines. Heterogeneity is a distinguishing feature TLSs, which may lead differences their functions. Growing evidence suggests that associated with various diseases, such cancers, autoimmune transplant rejection, chronic inflammation, infection, even ageing. However, detailed mechanisms behind these clinical associations not yet fully understood. The by TLS maturation localization affect immune function also unclear. Therefore, it necessary enhance understanding development at cellular molecular level, allow us utilize them improve microenvironment. In this review, we delve into composition, mechanism, potential therapeutic applications TLSs. Furthermore, discuss implications role markers response prognosis. Finally, summarize methods for detecting targeting Overall, provide comprehensive aim develop more effective strategies.
Language: Английский
Citations
19
Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
3
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: March 7, 2025
Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis development of tumor. The needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with improved survival outcomes many cancers. In recent years, increasing attention on the TLS tumor microenvironment, TLSs have emerged a novel target for anti-tumor therapy. Excitingly, studies shown contribution to immune responses. However, it unclear how form more effectively defense against through formation. Recent that inflammation plays role Interestingly, also found gut microbiota can regulate occurrence inflammation. Therefore, we here summarize potential effects microbiota- mediated or immunosuppression formation environments. Meanwhile, this review explores manipulate mature regulating microbiota/metabolites associated signal pathways potentially lead next-generation cancer immunotherapy.
Language: Английский
Citations
3
Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)
Published: March 5, 2025
Immune checkpoint blockade (ICB) inhibits tumor immune escape and has significantly advanced therapy. However, ICB benefits only a minority of patients treated may lead to many immune-related adverse events. Therefore, identifying factors that can predict treatment outcomes, enhance synergy with ICB, mitigate events is urgently needed. Tertiary lymphoid structures (TLS) are ectopic tissues arise from the periphery. They have been found be associated better prognosis improved clinical outcomes after TLS help address problems ICB. The multiple mechanisms action between remain unknown. This paper described potential interaction two explored their applications.
Language: Английский
Citations
1
Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown
Published: April 4, 2024
Abstract Cancer is the second leading cause of mortality worldwide. Despite recent advances in cancer treatment including immunotherapy with immune checkpoint inhibitors, new unconventional biomarkers and targets for detection, prognosis, are still high demand. Tumor cells characterized by mutations that allow their unlimited growth, program local microenvironment to support tumor spread towards distant sites. While a major focus has been on altered genomes proteomes, crucial signaling molecules such as lipids have underappreciated. One these membrane phospholipid phosphatidylserine (PS) usually found at cytosolic surfaces cellular membranes but can be rapidly massively shuttled extracellular leaflet plasma during apoptosis serve limiting factor responses. These immunosuppressive interactions exploited evade system. In this review, we describe mechanisms regulation tumors, discuss if PS may constitute an inhibitory checkpoint, current future strategies targeting reactivate tumor-associated
Language: Английский
Citations
6
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 13
Published: Feb. 5, 2024
Introduction The pro-inflammatory cytokine interleukin-23 (IL-23) has been implicated in colorectal cancer (CRC). Yet, the cell-specific contributions of IL-23 receptor (IL-23R) signaling CRC remain unknown. One cell types that highly expresses IL-23R are colonic regulatory T cells (Treg cells). aim this study was to define contribution Treg sporadic and inflammation-associated CRC. Methods In mice, role colitis-associated (CAC) investigated using azoxymethane/dextran sodium sulphate wild-type reporter mice (WT, Foxp3 YFP-iCre ), harboring a deletion ( Il23r ΔTreg ). examined utilizing orthotopic injection syngeneic colon line MC-38 submucosally into colon/rectum mice. function macrophages studied clodronate. Finally, single-cell RNA-seq previously published dataset human reanalyzed corroborate these findings. Results CAC, had increased tumor size dysplasia compared WT associated with decreased tumor-infiltrating macrophages. model, survival Additionally, tumors exhibited higher frequency IL-17 producing CD4 + cells. macrophage-dependent. These data suggest loss permits production by turn promotes clear tumors. analysis TCGA cancer, revealed IL23R expressed other cancers specifically tumor-associated Conclusion Inflammation carcinogenesis differs respect
Language: Английский
Citations
5
Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 1027 - 1027
Published: March 19, 2025
Resistance to immune checkpoint inhibitors (ICIs) represents a major challenge for the effective treatment of non-small cell lung cancer (NSCLC). Tumor heterogeneity has been identified as an important mechanism resistance in and increasingly implicated ICI resistance. The diversity clonality tumor neoantigens, which represent target epitopes tumor-specific cells, have shown impact efficacy immunotherapy. Advances genomic techniques further enhanced our understanding clonal landscapes within NSCLC their evolution response therapy. In this review, we examine role during surveillance highlight its spatial temporal revealed by modern technologies. We explore additional sources heterogeneity, including epigenetic metabolic factors, that come under greater scrutiny potential mediators response. finally discuss implications on ICIs strategies overcoming therapeutic
Language: Английский
Citations
0
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: May 6, 2025
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 9, 2025
Tertiary lymphoid structures (TLSs) are ectopic formations that develop in chronically inflamed tissues, including various solid tumours. In the context of gliomas, presence TLSs has recently attracted considerable attention because their potential implications tumour immunology and therapy. The immune microenvironment (TIME) plays a crucial role cancer progression, tumour-infiltrating cells (TILs) key players this environment. These cell aggregates, known as TLSs, display distinct characteristics across different However, central nervous system (CNS) tumours highly heterogeneous, environment within these is often more deficient than peripheral tissue This leads to differences formation function CNS variations particularly relevant glioma immunotherapy could have important for treatment strategies. review focuses on composition examines complexity glioblastoma (GBM) microenvironment, highlights unique GBM, providing new theoretical insights practical foundations targeting immunotherapy.
Language: Английский
Citations
0
Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0