Radiotherapy and Oncology, Journal Year: 2024, Volume and Issue: unknown, P. 110658 - 110658
Published: Dec. 1, 2024
Language: Английский
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract One of the goals clinical pharmacology is to optimize patient treatment by adopting new strategies which will increase efficacy and decrease adverse effects drugs. In literature, it has shown that effectiveness toxicity medications can vary significantly based on when they are administered, making timing a crucial factor in plans. Chronopharmacology relatively branch focuses adjusting drug administration times enhance outcomes. largely influenced an individual’s circadian rhythm refers periodic changes biological processes depending time day. The chronopharmacology influences practice, accumulating knowledge this field likely lead healthcare providers adopt for regimens. This review aims summarize impact particularly current practices highlight latest findings related chronophysiological mechanisms.
Language: Английский
Citations
2
Journal for ImmunoTherapy of Cancer, Journal Year: 2024, Volume and Issue: 12(3), P. e008011 - e008011
Published: March 1, 2024
Background Recent studies have demonstrated that earlier time-of-day infusion of immune checkpoint inhibitors (ICIs) is associated with longer progression-free survival (PFS) and overall (OS) among patients metastatic melanoma non-small cell lung cancer. These data are in line growing preclinical evidence the adaptive response may be more effectively stimulated day. We sought to determine impact ICI infusions on outcomes renal carcinoma (mRCC). Methods The treatment records all stage IV RCC who began therapy within a multicenter academic hospital system between 2015 2020 were reviewed. associations proportion administered prior noon (denoting morning infusions) PFS OS evaluated using univariate multivariable Cox proportional hazards regression. Results In this study, 201 mRCC (28% women) received ICIs followed over median 18 months (IQR 5–30). age at time initiation was 63 years 56–70). 101 (50%) ≥20% their (Group A) 100 <20% B). Across two comparison groups, initial agents consisted nivolumab (58%), plus ipilimumab (34%), pembrolizumab (8%). On analysis, Group A had compared those B (PFS HR 0.67, 95% CI 0.48 0.94, P univar =0.020; 0.57, 0.34 0.95, =0.033). significant findings persisted following adjustment for age, sex, performance status, International Metastatic Database Consortium risk score, pretreatment lactate dehydrogenase, histology, presence bone, brain, liver metastases 0.70, 0.50 0.98, multivar =0.040; 0.33 =0.043). Conclusions Patients benefit from receipt ICIs. Our consistent established mechanisms chrono-immunology, as well preceding analogous Additional prospective randomized trials warranted.
Language: Английский
Citations
14
British Journal of Cancer, Journal Year: 2024, Volume and Issue: 131(5), P. 783 - 796
Published: June 4, 2024
Abstract Background Tolerability and antitumour efficacy of chemotherapy radiation therapy can vary largely according to their time administration along the 24-h scale, due moderation molecular cellular mechanisms by circadian rhythms. Recent clinical data have highlighted a striking role dosing for cancer immunotherapy, thus calling critical evaluation. Methods Here, we review analyse through which rhythms influence outcomes on ICI therapies. We examine how rhythm disorders affect tumour immune microenvironment, as main mechanism linking clock cycles in ICIs efficacy. Results Real-life from 18 retrospective studies revealed that early time-of-day (ToD) infusion checkpoint inhibitors (ICIs) could enhance progression-free and/or overall survival up fourfold compared late ToD dosing. The involved total 3250 patients with metastatic melanoma, lung, kidney, bladder, oesophageal, stomach or liver 9 countries. Such large consistent differences effects only result previously ignored robust chronobiological mechanism. timing system coordinates cellular, tissue whole-body physiology timescale. Circadian are generated at level involves 15 specific genes. disruption trigger accelerate carcinogenesis, contribute treatment failure, possibly evasion resulting immunosuppressive microenvironment. Conclusions perspective emerging understanding regulation immunity now calls randomised trials establish recommendations personalised chrono-immunotherapies current forthcoming drugs.
Language: Английский
Citations
14
Head & Neck, Journal Year: 2024, Volume and Issue: 46(9), P. 2292 - 2300
Published: May 24, 2024
Abstract Background Prior work documented circadian rhythm impacts on efficacy and toxicity of cancer therapies. Methods Secondary analysis prospective, phase II trial metastatic HNSCC randomized to nivolumab+/−SBRT. Used cutoffs 1100 1630. Timing classified by first infusion or majority SBRT (e.g., PM defined two three fractions after 1630). Results Of 62 patients, there was no significant difference in median PFS between AM nivolumab ( n = 7, 175 days), 21, 58 Mid‐Day 34, 67 days; p 0.8). There with 4, 78 13, 111 15, 63 Grade 3–4 ORR. Sensitivity analyses other timepoints were negative. Conclusions Further may elucidate select tumors, therapies; however, we found effect this study.
Language: Английский
Citations
4
Asia-Pacific Journal of Pharmacotherapy & Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
The circadian clock and its inherent rhythms serve as the foundation for regulating many of body’s vital processes. Recent advances in medicine have leveraged these natural cycles through chronotherapy, practice timing drug administration to align with body's internal clock, enhance treatment outcomes. Endogenous clocks not only dictate physiological but also influence how drugs are absorbed, distributed, metabolized, excreted, thereby affecting both their therapeutic efficacy potential toxicity. When disrupted, resulting imbalance has been linked a range disorders, such cancer cardiovascular diseases, highlighting growing need time-sensitive strategies. Technological breakthroughs, including wearable sensors, digital health platforms, sophisticated machine learning techniques, now allow continuous, real-time monitoring biomarkers, which turn helps optimize regimens. In oncology, example, synchronizing chemotherapy, therapy, immunotherapy anti-inflammatory patient’s cycle shown effectiveness improve tolerability. Moreover, observed sex-based differences responses emphasize importance tailoring individual patient profiles. Emerging research is focusing on directly targeting molecular components, showing treating metabolic oncological conditions. However, fully integrating chronopharmacology into clinical will require development standardized protocols, regulatory backing, large-scale trials that incorporate biomarkers. Ultimately, merging biology strategies promises efficacy, minimize side effects, Future studies must address inter-individual variability, sex differences, misalignment harness chronotherapy’s personalized medicine.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 732 - 732
Published: Feb. 21, 2025
In the era of precision medicine, mounting evidence suggests that time therapy administration, or chronotherapy, has a great impact on treatment outcomes. Chronotherapy involves planning timing by considering circadian rhythms, which are 24 h oscillations in behavior and physiology driven synchronized molecular clocks throughout body. The value chronotherapy cancer is currently under investigation, notably effects efficacy side effects. Immune checkpoint inhibitor (ICI) promising treatment. However, many patients still experience disease progression need to stop early due There accumulating day at ICI administered can have substantial effect efficacy. Thus, it important investigate intersections this review, we provide brief overview rhythms context immunity cancer. Additionally, outline current applications for We synthesize 29 studies conducted date examine time-of-day administration therapy, its associated effects, sex differences both also discuss potential mechanisms underlying these observed results. Finally, highlight challenges area future directions research, including chronotherapeutic personalized medicine approach tailors individual patients’ rhythms.
Language: Английский
Citations
0
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: April 25, 2025
Language: Английский
Citations
0
Hepatology Research, Journal Year: 2025, Volume and Issue: 55(5), P. 741 - 751
Published: Feb. 9, 2025
Abstract Aim This study aimed to evaluate the impact of infusion timing time‐of‐day on clinical outcomes in patients with unresectable hepatocellular carcinoma (HCC) treated atezolizumab plus bevacizumab combination therapy. Methods A retrospective analysis was conducted using data from 751 HCC between September 2020 and April 2024. Patients were categorized into morning (AM; n = 351) afternoon (PM; 400) groups based time‐of‐day. Outcomes, including progression‐free survival (PFS), overall survival, objective response rate, disease control assessed Kaplan–Meier Cox regression analysis. Results The PFS significantly longer AM group (8.6 months, 95% CI 7.6–10.5) compared PM (6.0 5.4–7.0; p 0.006). In contrast, similar (AM: 24.7 months vs. PM: 21.4 months; 0.99). revealed that an independent favorable predictor (HR 1.23, 1.04–1.45). Additionally, demonstrated superior rate group, suggesting better tumor control. Conclusion Morning is associated improved rates patients, highlighting potential for optimizing treatment through circadian timing.
Language: Английский
Citations
0
Cell and Tissue Research, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 12, 2024
Language: Английский
Citations
2
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 18, 2024
Circadian rhythms, intrinsic cycles spanning approximately 24 h, regulate numerous physiological processes, including sleep–wake cycles, hormone release, and metabolism. These rhythms are orchestrated by the circadian clock, primarily located in suprachiasmatic nucleus (SCN) of hypothalamus. Disruptions whether due to genetic mutations, environmental factors, or lifestyle choices, can significantly impact health, contributing disorders such as sleep disturbances, metabolic syndrome, cardiovascular diseases. Additionally, there is a profound link between disruption development various cancer, influence on disease incidence progression. This incurred regulation clock pathways has its implication tumorigenesis, cell cycle control, DNA damage response, apoptosis, Furthermore, timing system modulates efficacy toxicity cancer treatments. In treatment, use chronotherapy optimize medical treatments, involves administering chemotherapy, radiation, other therapeutic interventions at specific intervals enhance minimize side effects. approach capitalizes variations cellular repair, progression, drug Preclinical clinical studies have demonstrated that improve index chemotherapeutic agents like cisplatin 5-fluorouracil enhancing anticancer activity reducing toxicity. Further research needed elucidate mechanisms underlying develop robust chronotherapeutic protocols tailored individual patients' profiles, potentially transforming care into more effective personalized treatment strategies.
Language: Английский
Citations
2