Amentoflavone for treating cardiocerebrovascular diseases and neurological disorders DOI Creative Commons
Zhang Hang,

Yunfei Ban,

De-mei Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 18, 2024

Amentoflavone (AME) is a flavonoid compound found in over 120 plants. Its extensive pharmacological activity for treating cardiocerebrovascular diseases and neurological disorders have attracted the attention of researchers recent years. However, owing to poor solubility low bioavailability AME, it has not been developed as drug these diseases. This review focuses on two aspects AME: First, provides detailed summary introduction AME based its chemical structure, physicochemical properties, plant sources, extraction purification methods, administration systems, pharmacokinetic properties. Second, summarizes effects disorders, specific mechanisms. aims promote use disorders. exhibits multiple activities, indicating potential natural Further studies pharmacokinetics toxicology are required ensure safety efficacy.

Language: Английский

Revealing the anti-senescence effects and related mechanisms of flavonoid extracts from the buds of Wikstroemia chamaedaphne Meisn on D-galactose-induced PC12 cells based on network pharmacology and transcriptomics DOI Creative Commons
Xiu-Ying Zhao,

Wen-Qian Liu,

Liwei Zhang

et al.

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 10, 2025

Abstract Background Natural products are an important source of drugs or lead compounds for the treatment senescence. The buds Wikstroemia chamaedaphne Meisn a traditional Chinese medicine to cure edema, schizophrenia and epilepsy. A flavonoid extract W. (FEW) was prepared from methanolic by our group previously, which including eight flavonoids with content (55.19 ± 0.32) %. In this study, anti-senescence effects related mechanisms FEW on D-galactose-induced PC12 cells were investigated first time. Results High doses D-galactose could induce cell senescence, whereas delay senescence decreasing SA-β-gal positivity, increasing SOD activity, reducing MDA levels, improving morphology, inhibiting cycle arrest down-regulating expression senescence-related proteins P16, P21 P53. Subsequently, potential underlying elucidated through integration network pharmacology transcriptomics. main signaling pathways involved found be cancer pathway, FOXO PI3k–Akt AGE–RAGE protein digestion uptake, etc. may pathway as revealed western blot experiments. Conclusion Our study that has effects. This suggest acts agent age-related neurological diseases.

Language: Английский

Citations

0

Procyanidins for the treatment of Parkinson's disease and ischemic stroke DOI
Weiran Li, Xinying Li, Pingping Wang

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106717 - 106717

Published: March 12, 2025

Language: Английский

Citations

0

Enhanced neuroprotection against Alzheimer’s disease by combining <i>Inula viscosa</i> with curcumin: an <i>in vitro</i> study DOI Creative Commons
Arash Alizadeh Yegani, Gülüzar Özbolat, Seydi Ahmet Şengül

et al.

Archives of Medical Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Introduction Alzheimer’s disease (AD), the most prevalent type of dementia among older individuals, is characterized by severe neurodegeneration with symptoms progressive loss cognitive capacity. We aimed to investigate effects curcumin (Curc) and Inula viscosa (IV) plant extracts on apoptosis oxidative stress in an amyloid-β (Aβ<i></i>)-induced vitro AD model. Material methods The human glioblastoma cell line (U87) was treated Aβ produce Treatment groups were: + Curc, IV, IV Curc. Cell viability assay performed analyze cytotoxicity. Caspase-3 (CASP3) levels were measured evaluate apoptosis. For stress, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), total antioxidant (TAS), oxidant (TOS) analyzed spectrophotometrically. Results Combinatory application Curc post-Aβ treatment increased U87 cells. Aβ-upregulated CASP3 markedly reduced upon co-treatment. Anti-oxidant parameters, i.e., SOD, CAT, GPx, TAS levels, significantly elevated Curc-treated group compared group. TOS level after exposure returned its basal Conclusions co-treatment apoptosis-related supported activity Aβ-induced model can be a promising therapeutic strategy against AD.

Language: Английский

Citations

0

Amentoflavone for treating cardiocerebrovascular diseases and neurological disorders DOI Creative Commons
Zhang Hang,

Yunfei Ban,

De-mei Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 18, 2024

Amentoflavone (AME) is a flavonoid compound found in over 120 plants. Its extensive pharmacological activity for treating cardiocerebrovascular diseases and neurological disorders have attracted the attention of researchers recent years. However, owing to poor solubility low bioavailability AME, it has not been developed as drug these diseases. This review focuses on two aspects AME: First, provides detailed summary introduction AME based its chemical structure, physicochemical properties, plant sources, extraction purification methods, administration systems, pharmacokinetic properties. Second, summarizes effects disorders, specific mechanisms. aims promote use disorders. exhibits multiple activities, indicating potential natural Further studies pharmacokinetics toxicology are required ensure safety efficacy.

Language: Английский

Citations

0