Metabolic pathways associated with Firmicutes prevalence in the gut of multiple livestock animals and humans DOI Creative Commons

Beatriz do Carmo Dias,

Alessandra P. Lamarca, Douglas Terra Machado

et al.

Animal Microbiome, Journal Year: 2025, Volume and Issue: 7(1)

Published: March 3, 2025

Dynamic interspecific interactions and environmental factors deeply impact the composition of microbiotic communities in gut. These intertwined with host's genetic background social habits cooperate synergistically as a hidden force modulating physiological health determinants, certain bacterial species being maintained from generation to generation. Firmicutes, one dominant phyla present across vertebrate classes, exhibits wide range functional capabilities colonization strategies. While ecological scenarios involving microbial specialization metabolic functions have been hypothesized, specific mechanisms that sustain persistence its taxa high diversity hosts remain elusive. This study fills this gap by investigating Firmicutes contributing their prevalence heritability host gut on metagenomes-assembled genomes collected 351 samples, covering 18 food-producing animals humans, breeds closely-related species. We observed belonging Acetivibrionaceae, Clostridiaceae, Lachnospiraceae, Ruminococcaceae, not well understood CAG-74 family were evolutionarily shared all hosts. prevalent exhibit pathways significantly correlated extra-host survival mechanisms, cell adhesion, transmission, highlighted sporulation, glycan biosynthesis, bile acid metabolism, short-chain fatty encoded genes. Our findings provide deeper understanding foundations governing distinct transmission modes, effective establishment, maintenance offering new perspectives both well-known poorly characterized

Language: Английский

Soil microbiomes and one health DOI
Samiran Banerjee, Marcel G. A. van der Heijden

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 21(1), P. 6 - 20

Published: Aug. 23, 2022

Language: Английский

Citations

489
Harnessing the microbiome to prevent global biodiversity loss DOI Open Access
Raquel S. Peixoto, Christian R. Voolstra, Michael Sweet

et al.

Nature Microbiology, Journal Year: 2022, Volume and Issue: 7(11), P. 1726 - 1735

Published: July 21, 2022

Language: Английский

Citations

165
Potential Causes of Spread of Antimicrobial Resistance and Preventive Measures in One Health Perspective-A Review DOI Creative Commons
Habtamu Endale, Mesfin Mathewos,

Debela Abdeta

et al.

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 7515 - 7545

Published: Dec. 1, 2023

Abstract: Antimicrobial resistance, referring to microorganisms' capability subsist and proliferate even when there are antimicrobials is a foremost threat public health globally. The appearance of antimicrobial resistance can be ascribed anthropological, animal, environmental factors. Human-related causes include overuse misuse in medicine, antibiotic-containing cosmetics biocides utilization, inadequate sanitation hygiene settings. Prophylactic therapeutic overuse, using as feed additives, microbes resistant antibiotics genes animal excreta, residue found animal-origin food excreta animals related contributive factors for the antibiotic emergence spread. Environmental including naturally existing genes, improper disposal unused antimicrobials, contamination from waste settings, farms, pharmaceutical industries, use agricultural chemicals facilitatet its Wildlife has plausible role Adopting one-health approach involving properly humans, improving spaces implementing coordinated governmental regulations crucial combating resistance. Collaborative cooperative involvement stakeholders public, veterinary ecological sectors circumvent problem effectively. Keywords: one health, gene, environment, wildlife

Language: Английский

Citations

62
Horizon scanning the application of probiotics for wildlife DOI Creative Commons
Neus Garcias‐Bonet, Anna Roik, Braden Tierney

et al.

Trends in Microbiology, Journal Year: 2023, Volume and Issue: 32(3), P. 252 - 269

Published: Sept. 25, 2023

The provision of probiotics benefits the health a wide range organisms, from humans to animals and plants. Probiotics can enhance stress resilience endangered many which are critically threatened by anthropogenic impacts. use so-called 'probiotics for wildlife' is nascent application, field needs reflect on standards its development, testing, validation, risk assessment, deployment. Here, we identify main challenges this emerging intervention provide roadmap validate effectiveness wildlife probiotics. We cover essential inert negative controls in trials investigation probiotic mechanisms action. also suggest alternative microbial therapies that could be tested parallel with application. Our recommendations align approaches used humans, aquaculture, plants concept wildlife.

Language: Английский

Citations

36
Host Genetic Determinants of the Microbiome Across Animals: From Caenorhabditis elegans to Cattle DOI Open Access
Erica Ryu, Emily Davenport

Annual Review of Animal Biosciences, Journal Year: 2022, Volume and Issue: 10(1), P. 203 - 226

Published: Feb. 15, 2022

Animals harbor diverse communities of microbes within their gastrointestinal tracts. Phylogenetic relationship, diet, gut morphology, host physiology, and ecology all influence microbiome composition between animal clades. Emerging evidence points to genetics as also playing a role in determining microbial species. Here, we discuss recent advances the study heritability across variety species . Candidate gene discovery-based studies humans, mice, Drosophila, Caenorhabditis elegans, cattle, swine, poultry, baboons reveal trends types that are heritable genes pathways involved shaping microbiome. Heritable tend be phylogenetically restricted. Host genetic variation immune- growth-related drives abundances these bacteria gut. With only small slice metazoan branch tree life explored date, this is an area rife with opportunities shed light into mechanisms governing host–microbe relationships.

Language: Английский

Citations

38
Antiviral Effects and Underlying Mechanisms of Probiotics as Promising Antivirals DOI Creative Commons
Yanjin Wang,

Assad Moon,

Jingshan Huang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: June 6, 2022

Probiotics exert a variety of beneficial effects, including maintaining homeostasis and the balance intestinal microorganisms, activating immune system, regulating responses. Due to effects probiotics, wide range probiotics have been developed as probiotic agents for animal human health. Viral diseases cause serious economic losses livestock every year remain great challenge animals. Moreover, strategies prevention control viral are limited. Viruses enter host through skin mucosal surface, in which colonized by hundreds millions microorganisms. The antiviral proved, modulation chemical, microbial, physical, barriers various metabolites, signaling pathways. It is significance yet far from enough elucidate mechanisms probiotics. major interest this review discuss underlying provide targets development novel antivirals.

Language: Английский

Citations

29
Shift of Feeding Strategies from Grazing to Different Forage Feeds Reshapes the Rumen Microbiota To Improve the Ability of Tibetan Sheep (Ovis aries) To Adapt to the Cold Season DOI Creative Commons
Xiongxiong Cui, Zhaofeng Wang,

Penghui Guo

et al.

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(2)

Published: Feb. 21, 2023

The dynamics of ruminant-rumen microbiome symbiosis associated with feeding strategies in the cold season were examined. Twelve pure-grazing adult Tibetan sheep (Ovis aries) (18 months old; body weight, 40 ± 0.23 kg) transferred from natural pasture to two indoor feedlots and fed either a native-pasture diet (NPF group) or an oat hay (OHF (

Language: Английский

Citations

20
Yeasts and yeast-based products in poultry nutrition DOI Creative Commons
Shahna Fathima,

Revathi Shanmugasundaram,

Mamduh Sifri

et al.

The Journal of Applied Poultry Research, Journal Year: 2023, Volume and Issue: 32(2), P. 100345 - 100345

Published: Feb. 16, 2023

The poultry industry is interested in alternatives to antibiotics improve production performance and reduce the incidence of enteric diseases. For more than a decade, yeast fermentation products have been used feed growth efficiency livestock. cell wall comprised numerous polysaccharides: mannans, chitin, β-1,3-glucans, 1,6-glucans. These are major bioactive molecules that can impart health benefits host. Yeast modulate host immune response, load pathogens, ameliorate pathologic effects infections poultry. principal mechanisms action probiotics prebiotics competitive exclusion antagonism, immunomodulation, effect on digestive enzymes, direct nutritional benefits. However, only few species yeast, such as Saccharomyces thoroughly studied for their probiotic potential. Novel species, whole Pichia guilliermondii (Citrsitim) cells, recently shown prebiotic properties demand further investigation. A thorough understanding gut mycobiota required formulate tailor-made avian

Language: Английский

Citations

18
Feeding hempseed cake alters the bovine gut, respiratory and reproductive microbiota DOI Creative Commons

Thomas Winders,

Devin B. Holman,

Kaycie N. Schmidt

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: May 19, 2023

Abstract A growing number of studies have investigated the feasibility utilizing hemp by-products as livestock feedstuffs; however, their impact on microbiomes remains unexplored. Here, we evaluated effects feeding hempseed cake gastrointestinal, respiratory, and reproductive microbiota in beef heifers. Angus-crossbred heifers (19-months old, initial body weight = 494 ± 10 kg [SE]) were fed a corn-based finishing diet containing 20% substitute for corn dried distillers’ grains with solubles (DM basis; Control; n 16/group) 111 days until slaughter. Ruminal fluid deep nasopharyngeal swabs (days 0, 7, 42, 70 98), vaginal uterine (at slaughter) collected, assessed using 16S rRNA gene sequencing. Diet affected community structure ruminal (d 7−98; 0.06 ≤ R 2 0.12; P < 0.05), 98; 0.18; 0.001), (R 0.06; 0.01) microbiota. Heifers had increased microbial diversity rumen, reduced richness vagina, greater uterus. In addition to distinct communities nasopharynx, vagina uterus, identified 28 core taxa that shared (≥ 60% all samples) across these sampling locations. Feeding appeared alter bovine gut, respiratory Our results suggest future research aiming evaluate use should consider animal microbiome mediated health efficiency. findings also highlight need evaluating hemp-associated food personal care products human microbiome.

Language: Английский

Citations

18
Exploring the Potential Molecular Mechanisms of Interactions between a Probiotic Consortium and Its Coral Host DOI Creative Commons

Phillipe M. Rosado,

Pedro Cardoso, João G. Rosado

et al.

mSystems, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 23, 2023

Probiotics are currently the main hope as a potential medicine for corals, organisms that considered marine “canaries of coal mine” and threatened with extinction. Our experiments have proved concept probiotics mitigate coral bleaching can also prevent mortality.

Language: Английский

Citations

17