A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance

PLoS Genetics, Journal Year: 2024, Volume and Issue: 20(3), P. e1011178 - e1011178

Published: March 28, 2024

C . elegans can learn to avoid pathogenic bacteria through several mechanisms, including bacterial small RNA-induced learned avoidance behavior, which be inherited transgenerationally. Previously, we discovered that a RNA from clinical isolate of Pseudomonas aeruginosa , PA14, induces and transgenerational inheritance in is an important human pathogen, there are other Pseudomonads elegans’ natural habitat, but it unclear whether ever encounters PA14-like the wild. Thus, not known if RNAs found habitat also regulate host behavior produce heritable behavioral effects. Here screened set wild bacteria, vranovensis strain isolated microbiota, GRb0427, regulates worm behavior: worms this bacterium following exposure, for four generations. The response entirely mediated by bacterially-produced RNAs, induce inheritance, providing further support such mechanisms learning exist We identified Pv1, expressed P has 16-nucleotide match exon gene maco-1 Pv1 both necessary sufficient Grb0427. However, results beneficial microbiome strain, mendocina Our findings suggest RNA-mediated regulation its may functional environment, potentially maladaptive favor reversal memory after few data different systems evolved independently, define shared molecular features transgenerationally-inherited

Language: Английский

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Epigenetics and individuality: from concepts to causality across timescales

Nature Reviews Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Language: Английский

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Perception of a pathogenic signature initiates intergenerational protection

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Transgenerational epigenetic inheritance increases trait variation but is not adaptive

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 20, 2024

Abstract Understanding processes that can produce adaptive phenotypic shifts in response to rapid environmental change is critical reducing biodiversity loss. The ubiquity of environmentally induced epigenetic marks has led speculation inheritance could potentially enhance population persistence change. Yet, the magnitude and fitness consequences carried beyond maternal are largely unknown. Here, we tested how transgenerational (TEI) shapes Daphnia clones stressor Microcystis . We split individuals from each eight genotypes into exposure control treatments (F0 generation) tracked their descendants F3 generation. found reduced rates survival individual growth no consistent effect on offspring production. Increase trait variance relative F0 generations suggests potential for heritable bet hedging driven by TEI, which impact dynamics. Our findings counter working hypothesis TEI a generally mechanism likely prevent extinction populations inhabiting rapidly changing environments. One sentence summary Transgenerational exposed revealed negative effects rates, challenging hypotheses general selective advantage.

Language: Английский

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A natural bacterial pathogen ofC. elegansuses a small RNA to induce transgenerational inheritance of learned avoidance

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 21, 2023

Previously, we discovered that a small RNA from clinical isolate of

Language: Английский

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The Inheritance of an Acquired Taste: Learning and Passing on New Food Odor Preferences in Butterflies

Published: Jan. 1, 2024

Language: Английский

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Brain and gonadal genes are differentially expressed inBicyclus anynanabutterfly larvae that learned a heritable novel food odor preference

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

Abstract Bicyclus anynana butterfly larvae learn to prefer novel odors added their plant food and transmit those learned preferences the next generation. However, molecular mechanisms regulating inheritance of this acquired preference remain unexplored. Here we examined how larval diet affected gene expression patterns in brain as well gonads adults explore a potential genetic basis inheritance. We fed B. leaves coated with banana odor (isoamyl acetate), or control solution, performed five choice assays on individual during development identify individuals that showed majority for treatment they were with. then dissected male female brains, adult spermatophores, oocytes from individuals, profiled mRNA all tissues micro-RNA (miRNA) only. Our results show there are 83 differentially expressed genes (DEGs) across tissue types groups, which 23 play roles metabolism, transcription, response various chemical stimuli, olfactory pathways. MiRNAs did not differ treatments, but discovered 57 miRNAs oocytes. The DEGs epigenetic factors can regulate preference. Still, caution is required was no overlap between gonads.

Language: Английский

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The science of longevity and the quest to solve an age-old problem

Nature Aging, Journal Year: 2023, Volume and Issue: 3(11), P. 1313 - 1314

Published: Oct. 30, 2023

Language: Английский

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