Metabolic coordination of T cell quiescence and activation

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 20(1), P. 55 - 70

Published: Aug. 12, 2019

Language: Английский

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Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(10), P. 569 - 589

Published: Aug. 22, 2019

Language: Английский

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Mitochondrial Metabolism as a Target for Cancer Therapy

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(3), P. 341 - 352

Published: July 14, 2020

Language: Английский

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Metabolomics in cancer research and emerging applications in clinical oncology

CA A Cancer Journal for Clinicians, Journal Year: 2021, Volume and Issue: 71(4), P. 333 - 358

Published: May 13, 2021

Abstract Cancer has myriad effects on metabolism that include both rewiring of intracellular to enable cancer cells proliferate inappropriately and adapt the tumor microenvironment, changes in normal tissue metabolism. With recognition fluorodeoxyglucose‐positron emission tomography imaging is an important tool for management many cancers, other metabolites biological samples have been spotlight diagnosis, monitoring, therapy. Metabolomics global analysis small molecule like ‐omics technologies can provide critical information about state are otherwise not apparent. Here, authors review how therapies interact with at cellular systemic levels. An overview metabolomics provided a focus currently available they applied clinical translational research setting. The also discuss could be further leveraged future improve patients cancer.

Language: Английский

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The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 66, P. 101249 - 101249

Published: Dec. 29, 2020

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism response to changes in the inflammatory microenvironment may play key role cartilage degeneration OA progression. Under conditions environmental stress, chondrocytes tend adapt their microenvironmental shifting from one metabolic pathway another, for example oxidative phosphorylation glycolysis. Similar occur other cells, including synoviocytes. Switching between these pathways implicated alterations that involve mitochondrial dysfunction, enhanced anaerobic glycolysis, altered lipid amino acid metabolism. The shift glycolysis mainly regulated AMP-activated protein kinase (AMPK) mechanistic target rapamycin (mTOR) pathways. Chondrocyte are likely be feature different phenotypes. Determining has revealed features pathogenesis. Future research should place greater emphasis on immunometabolism as means understand pathophysiology age-related OA. This knowledge will advance development new drugs against therapeutic targets significance.

Language: Английский

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Amino Assets: How Amino Acids Support Immunity

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(2), P. 154 - 175

Published: July 9, 2020

Language: Английский

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Helper T cell differentiation

Cellular and Molecular Immunology, Journal Year: 2019, Volume and Issue: 16(7), P. 634 - 643

Published: March 12, 2019

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Exosome-based immunotherapy: a promising approach for cancer treatment

Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)

Published: Nov. 12, 2020

Abstract In the era of rapid development cancer immunotherapy, there is a high level interest in application cell-released small vesicles that stimulate immune system. As cell-derived nanovesicles, exosomes show great promise immunotherapy because their immunogenicity and molecular transfer function. The cargoes carried on have been recently identified with improved technological advances play functional roles regulation responses. particular, derived from tumor cells exhibit unique composition profiles are directly involved anticancer immunotherapy. More importantly, can deliver to targeted thus influence phenotype immune-regulation functions cells. Accumulating evidence over last decade has further revealed participate multiple cellular processes contributing therapeutic effects, showing dual characteristics promoting suppressing cancer. potential field huge, may become most effective vaccines, as well antigen/drug carriers. Understanding how be utilized therapy important for controlling progression; additionally, implications diagnostics novel strategies. This review discusses role carriers an anti-cancer response predictive markers activation; furthermore, it summarizes mechanism clinical prospects exosome-based human

Language: Английский

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New insights into the immune functions of complement

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(8), P. 503 - 516

Published: May 2, 2019

Language: Английский

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Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

Cell, Journal Year: 2021, Volume and Issue: 184(16), P. 4168 - 4185.e21

Published: July 2, 2021

Language: Английский

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