Post-COVID syndrome

Deutsches Ärzteblatt international, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 10, 2023

As defined by the WHO, term post-COVID syndrome (PCS) embraces a group of symptoms that can occur following acute phase SARS-CoV-2 infection and as consequence thereof. PCS is found mainly in adults, less frequently children adolescents. It develop both patients who initially had only mild or none at all those severe course coronavirus disease 2019 (COVID-19).The data presented here were derived from systematic literature review.PCS occurs up to 15% unvaccinated adults infected with SARS-CoV-2. The prevalence has decreased most recent pandemic lower after vaccination. pathogenesis not yet been fully elucidated. Virustriggered inflammation, autoimmunity, endothelial damage (to blood vessels), persistence virus are thought be causative. Owing broad viral tropism, different organs involved vary. To date, there hardly any evidence-based recommendations for definitive diagnosis its treatment.The gaps our knowledge mean better documentation necessary compile on which early detection, diagnosis, treatment based. ensure best possible care PCS, regional centers networks embracing existing structures healthcare system sectors providers should set structured algorithms established. Given sometimes serious consequences affected, it seems advisable keep number infections low protective measures tailored prevailing situation.

Language: Английский

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Prevalence and risk factors for persistent symptoms after COVID-19: a systematic review and meta-analysis

Clinical Microbiology and Infection, Journal Year: 2023, Volume and Issue: 30(3), P. 328 - 335

Published: Oct. 20, 2023

Language: Английский

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Practical Recommendations for Exercise Training in Patients with Long COVID with or without Post-exertional Malaise: A Best Practice Proposal

Sports Medicine - Open, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 24, 2024

Abstract People with long COVID may suffer from a wide range of ongoing symptoms including fatigue, exertional dyspnea, reduced exercise performance, and others. In particular, impaired performance is condition that can be recovered in many people through an individualized physical training program. However, clinical experience has shown the presence post-exertional malaise (PEM) significant barrier to COVID. Currently, there no guideline or consensus available on how apply this cohort. Therefore, we conducted literature review PubMed library using following search terms: “COVID”, “post-COVID”, “long COVID” “exercise” searching for studies January 2020 2024. Data 46 trials were included. Exercise regimes very heterogeneous none these reported management PEM context Based feedback additional survey was answered by 14 international experts field COVID, combined authors´ own extensive practical experience, best practice proposal recommendations been developed. This differentiates procedures according no, mild/moderate severe These guide allied healthcare professionals worldwide initiating adjusting programs stratified severity PEM.

Language: Английский

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Microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 19, 2024

Abstract Although some studies have shown neuroimaging and neuropsychological alterations in post-COVID-19 patients, fewer combined neuropsychology evaluations of individuals who presented a mild acute infection. Here we investigated cognitive dysfunction brain changes group mildly infected individuals. We conducted cross-sectional study 97 consecutive subjects (median age 41 years) without current or history psychiatric symptoms (including anxiety depression) after infection, with median 79 days (and mean days) diagnosis COVID-19. performed semi-structured interviews, neurological examinations, 3T-MRI scans, assessments. For MRI analyses, included non-infected 77 controls. The white matter (WM) investigation diffusion tensor images (DTI) functional connectivity resting-state (RS-fMRI). patients reported memory loss (36%), fatigue (31%) headache (29%). quantitative analyses confirmed (83% participants), excessive somnolence (35%), impaired phonemic verbal fluency (21%), categorical (13%) logical immediate recall (16%). WM DTI revealed higher axial diffusivity values post-infected compared to Compared controls, there were no significant differences the posterior cingulum cortex. There correlations between scores features RS-fMRI). Our results suggest persistent impairment subtle abnormalities depression symptoms. longitudinal will clarify whether these are temporary permanent.

Language: Английский

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Telerehabilitation, A Viable Option in Patients with Persistent Post-COVID Syndrome: A Systematic Review

Healthcare, Journal Year: 2023, Volume and Issue: 11(2), P. 187 - 187

Published: Jan. 7, 2023

The number of patients with post-COVID-19 syndrome continues to increase considerably, having serious healthcare, social and economic repercussions. objective this study is describe the effectiveness telerehabilitation alleviate symptoms syndrome. A systematic review was conducted using information available on four databases (PubMed, Medline, Scielo PEDRo) these until November 2022. MeSH search terms were: Post-COVID syndrome, Post-COVID-19, Long COVID, Telerehabilitation, Physiotherapy, Rehabilitation, Virtual, Home care. Six articles were included which provided 140 patients, detailing their symptomatology, assessment, treatment monitoring. variables measured dyspnea, fatigue, physical performance quality life. All studies aerobic anaerobic exercises. Most notable among techniques used rib cage expansion exercises, respiratory control thoracic stretching, patient education, Mindfulness virtual reality games address physical, mental relaxation aspects. use could be an effective tool for persistent after suffering from COVID-19. It has been shown in that improve both

Language: Английский

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Long-term effects of SARS-CoV-2 infection on human brain and memory

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: June 29, 2023

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have caused several waves of outbreaks. From the ancestral strain to Omicron variant, SARS-CoV-2 has evolved with high transmissibility and increased immune escape against vaccines. Because multiple basic amino acids in S1-S2 junction spike protein, widespread distribution angiotensin-converting enzyme (ACE2) receptor human body transmissibility, can infect organs led over 0.7 billion infectious cases. Studies showed that infection cause more than 10% patients Long-COVID syndrome, including pathological changes brains. This review mainly provides molecular foundations for understanding mechanism invading brain basis interfering memory, which are associated dysfunction, syncytia-induced cell death, persistence infection, microclots biopsychosocial aspects. We also discuss strategies reducing syndrome. Further studies analysis shared researches will allow further clarity regarding long-term health consequences.

Language: Английский

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Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: March 30, 2024

Language: Английский

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SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort study

The Lancet Regional Health - Americas, Journal Year: 2025, Volume and Issue: 42, P. 100984 - 100984

Published: Jan. 8, 2025

Language: Английский

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Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 6, 2025

Since its emergence in 2019, COVID-19 has continued to pose significant threats both the physical and mental health of global population, as well healthcare systems worldwide (Raman et al., Eur Heart J 43:1157–1172, 2022). Emerging evidence indicates that may lead post-acute syndrome (PACS) with cardiovascular implications, potentially driven by factors such ACE2 interaction viruses, systemic inflammation, endothelial dysfunction. However, there remains a limited amount research on manifestations PACS, which delay development optimal treatment strategies for affected patients. Therefore, it is crucial investigate prevalence sequelae patients determine whether infection acts an independent risk factor these outcomes. This meta-analysis adhered PRISMA guidelines was registered PROSPERO (CRD42024524290). A systematic search PubMed, Embase, Cochrane Library conducted up March 17, 2024. The primary outcomes included hypertension, palpitations, chest pain, pooled effect estimate reported proportions odds ratios (ORs) 95% confidence intervals (CIs). Sensitivity subgroup analysis were performed assess robustness results identify sources heterogeneity. total 37 studies, encompassing 2,965,467 patients, analysis. Pooled from case–control studies revealed that, compared control group, ORs pain group 4.0 (95% CI: 1.6, 10.0). palpitation hypertension 3.4 1.1, 10.2) 1.7 1.8), respectively. PACS experiencing palpitation, 22% 14%, 33%), 18% 13%, 24%), 19% 12%, 31%), Our findings indicate 15% experience sequelae. Furthermore, significantly increases likelihood developing uninfected individuals. Future should prioritize investigating underlying pathological mechanisms targeted preventive management strategies. CRD42024524290.

Language: Английский

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Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects

Rheumatology Science and Practice, Journal Year: 2024, Volume and Issue: 62(1), P. 32 - 54

Published: Feb. 29, 2024

The pandemic of coronavirus disease 2019 (COVID-19), etiologically related to the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus-2), has drawn attention new clinical and fundamental problems in immunopathology human diseases associated with virus-induced autoimmunity autoinflammation. provision that “the experience gained rheumatology process studying pathogenetic mechanisms pharmacotherapy immunoinflammatory rheumatic as most common severe forms autoimmune autoinflammatory pathology humans will be demand for deciphering nature pathological processes underlying COVID-19 developing approaches effective pharmacotherapy” was confirmed numerous studies conducted over next 3 years midst pandemic. main focus on a critical analysis data regarding role inflammation, which basis pathogenesis immune-mediated context COVID-19.

Language: Английский

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