Archaeal key-residents within the human microbiome: characteristics, interactions and involvement in health and disease

Current Opinion in Microbiology, Journal Year: 2022, Volume and Issue: 67, P. 102146 - 102146

Published: April 12, 2022

Since the introduction of Archaea as new domain life more than 40 years ago, they are no longer regarded eccentric inhabitants extreme ecosystems. These microorganisms widespread in various moderate ecosystems, including eukaryotic hosts such humans. Indeed, members archaeal community now recognized paramount constituents human microbiome, while their definite role disease or health is not fully elucidated and pathogen has been reported. Here, we present a brief overview archaea residing on body, with specific focus common lineages Methanobrevibacter, Methanosphaeraand Methanomassilococcales.

Language: Английский

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Landscape of the gut archaeome in association with geography, ethnicity, urbanization, and diet in the Chinese population

Microbiome, Journal Year: 2022, Volume and Issue: 10(1)

Published: Sept. 13, 2022

Abstract Background and aims The human gut is home to a largely underexplored microbiome component, the archaeome. Little known of impact geography, urbanization, ethnicity, diet on archaeome in association with host health. We aim delineate variation healthy individuals its environmental factors homeostasis. Methods Using metagenomic sequencing, we characterized fecal archaeomes 792 adult subjects from 5 regions China, spanning 6 ethnicities (Han, Zang, Miao, Bai, Dai, Hani), consisting both urban rural residents for each ethnicity. In addition, sampled 119 variables (including lifestyle, diet, blood parameters) interrogated influences those factors, individually combined, variations. Results Population geography had strongest composition, followed by dietary habit, Overall, metadata cumulative effect size 11.0% variation. Urbanization decreased α-diversity (intrinsic microbial diversity) β-diversity (inter-individual dissimilarities) archaeome, archaea-to-bacteria ratios feces, whereas were enriched Methanobrevibacter smithii feces. Consumption buttered milk tea (a characteristic Zang population) was associated increased abundance M. . at central hub archaeal-bacterial interactions microecology, where it positively correlated abundances multitude short chain fatty acid (SCFA)-producing bacteria Roseburia faecis , Collinsella aerofaciens Prevotella copri ). Moreover, levels cholinesterase population, coinciding increasing prevalence noncommunicable diseases (such as dementia) during urbanization. Conclusions Our data highlight marked contributions (geography, habitual diets) variations across individuals, underscore urbanization health modern society.

Language: Английский

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Unlocking secrets of microbial ecotoxicology: recent achievements and future challenges

FEMS Microbiology Ecology, Journal Year: 2023, Volume and Issue: 99(10)

Published: Sept. 4, 2023

Environmental pollution is one of the main challenges faced by humanity. By their ubiquity and vast range metabolic capabilities, microorganisms are affected with consequences on host organisms functioning environment. They also play key roles in fate pollutants through degradation, transformation, transfer organic or inorganic compounds. Thus, they crucial for development nature-based solutions to reduce bio-based environmental risk assessment chemicals. At intersection between microbial ecology, toxicology, biogeochemistry, ecotoxicology a fast-expanding research area aiming decipher interactions microorganisms. This perspective paper gives an overview identified Ecotoxicomic network within emerging One Health framework light ongoing interest biological approaches remediation current state art ecology. We highlight prevailing knowledge gaps pitfalls exploring complex among environment context chemical pinpoint areas where future efforts needed.

Language: Английский

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Evolution of microbial genomics: conceptual shifts over a century

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 389 - 415

Published: Jan. 1, 2025

Language: Английский

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A Spotlight on Archaea in Humans, Livestock and Poultry: A Review

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(2)

Published: March 1, 2025

ABSTRACT The microbiota includes prokaryotes (archaea and bacteria) eukaryotes. Archaea are single‐celled essential part of gut microbiome. Researches on archaea in ruminants humans more than mono‐gastric. low abundance the depends method used (metagenomics or meta‐transcriptomic) age people poultry. lack complete recognition is due to their small number identifying them (16S rRNA gene primers). uses include analytical kit, reduce oil pollution, archaeosomes drugs production, vaccines agents, lipid carriers pharmaceutical industry molybdenum extraction nuclear industry. nutritional functions methanogenic including feed utilization (ruminants) efficiency, hydrogen reducing (human), fat deposition enhancement energy harvesting mice, CAZymes genes, cecal fermentation, syntrophic potential, carotenoid source improved transit time appetite SCFAs production. acting as antibiotics (produce archaeocins, sulfolobicins halocin KPS1) probiotics (archaeobiotics) can TMAU (trimethylaminuria) disease, cardiovascular diseases (CVDs), atherosclerosis, brain abscess, cancer, colorectal inflammatory bowel disease (IBD), constipation, obesity, food allergies, asthma anti‐inflammation which be prevented by using archaea, other homeostasis, heat shock protein (HSP) production aging.

Language: Английский

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Diversity and environmental distribution of Asgard archaea in shallow saline sediments

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

In recent years, our understanding of archaeal diversity has greatly expanded, especially with the discovery new groups like Asgard archaea. These archaea show diverse phylogenetic and genomic traits, enabling them to thrive in various environments. Due their close relationship eukaryotes, a large number metagenomic studies have been performed on Research fine scale distribution, quantification saline aquatic sediments where they mostly occur, has, however, remained scarce. this study, we investigated depths shallow sediment cores from three distinct European environments: Baltic Sea near Hiddensee, coastal Lake Techirghiol Romania, an estuarine canal Piran, Slovenia. Based 16S rDNA amplicon sequencing, observe variation relative abundance occurrence at least seven different that are between environments depth distribution. Lokiarchaeia Thorarchaeia emerge as dominant across all sites, reaching maximal abundances 2.28 2.68% total microbial communities respectively, approx. 5.21% Hiddensee. Quantitative PCR assays provide insights into absolute Lokiarchaeia, supporting patterns distribution sediments. Co-occurrence network analysis indicates potential partners groups. Overall, study shows found stable component layers considerably diversified macro- microscales.

Language: Английский

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Redefining paradigms in the archaeal virus-host arms race

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Archaeal antiviral defense systems remain poorly characterized despite recent advances in understanding prokaryotic immunity. Here, we analyze 7,747 archaeal genomes, the largest and most diverse dataset to date, revealing a striking disparity system prevalence diversity compared Bacteria. Nearly one-third of genomes lack known beyond CRISPR-Cas restriction-modification (in contrast only 2.2% bacterial genomes), 31% contain systems, far below previous estimates. While many appear restricted Bacteria, several single-gene candidate (PDCs) are enriched Archaea. Phylogenetic analyses suggest that PDC-S27, PDC-S70, PDC-M05 likely originated Archaea, representing rare contributions immune repertoire. Consistent with earlier studies, our findings support existence deep evolutionary links between eukaryotic for argonautes viperins. These highlight both underexplored nature significance immunity, calling expanded efforts uncover archaeal-specific improve evolution across domains life.

Language: Английский

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Ribosome and Transfer RNA Biogenesis

Published: April 25, 2025

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The expanding Asgard archaea and their elusive relationships with Eukarya

mLife, Journal Year: 2022, Volume and Issue: 1(1), P. 3 - 12

Published: March 1, 2022

Abstract The discovery of Asgard archaea and the exploration their diversity over last 6 years have deeply impacted scientific community working on eukaryogenesis, rejuvenating an intense debate topology universal tree life (uTol). Here, we discuss how this is by two recent publications that expand number lineages eukaryotic signature proteins (ESPs). We some main difficulties can impair phylogenetic reconstructions uTol suggest about its not settled. notably hypothesize existence horizontal gene transfers between ancestral Asgards proto‐eukaryotes could result in observed abnormal behaviors ESPs marker proteins. This hypothesis relevant regardless scenario considered regarding eukaryogenesis. It implies were already diversified before common ancestor shared same biotopes with proto‐eukaryotes. might be still living symbiosis today modern Eukarya.

Language: Английский

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Experimental warming leads to convergent succession of grassland archaeal community

Nature Climate Change, Journal Year: 2023, Volume and Issue: 13(6), P. 561 - 569

Published: May 4, 2023

Language: Английский

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