JAMA Neurology,
Journal Year:
2018,
Volume and Issue:
75(5), P. 582 - 582
Published: Jan. 29, 2018
Circadian
rhythm
disturbances
occur
in
symptomatic
Alzheimer
disease
(AD)
and
have
been
hypothesized
to
contribute
pathogenesis.
However,
it
is
unknown
whether
circadian
changes
during
the
presymptomatic
phase
of
disease.To
examine
associations
between
function,
aging,
preclinical
AD
pathology
cognitively
normal
adults.This
cross-sectional
study
was
conducted
using
community
volunteers
from
Knight
Alzheimer's
Disease
Research
Center
at
Washington
University
St
Louis.
Cognitively
participants
(n
=
205)
underwent
7
14
days
actigraphy
their
home
environment
2010
2012,
addition
clinical
assessment,
amyloid
imaging
with
Pittsburgh
Compound
B
(PiB),
cerebrospinal
fluid
biomarker
collection.
Data
collected
3
years
before
6
months
after
were
included.
Sixteen
excluded
owing
incomplete
data
collection.Circadian
analysis
performed
on
methods:
cosinor,
nonparametric,
empirical
mode
decomposition.
Preclinical
assessed
by
longitudinal
PiB,
collection.Data
189
included
analyses.
The
mean
(SD)
age
66.6
(8.3)
years,
121
(64%)
women.
Older
(β
.247;
P
.003)
male
sex
.170;
.04),
absence
pathology,
associated
a
significant
increase
intradaily
variability,
nonparametric
measure
rest-activity
fragmentation,
as
well
decreased
amplitude
several
measures.
After
correction
for
sex,
presence
plaque
positive
PiB
(mean
[SD],
0.804
[0.187]
negative
vs
0.875
[0.178]
positive;
.05)
or
increasing
phosphorylated-tau
β
42
ratio
.231;
.008),
increased
indicating
fragmentation.Preclinical
independent
sex.
Aging
also
dysfunction
independently
particularly
men.
abnormalities
suggests
that
could
early
pathogenesis
serve
disease.
Science,
Journal Year:
2016,
Volume and Issue:
354(6315), P. 1008 - 1015
Published: Nov. 24, 2016
A
majority
of
mammalian
genes
exhibit
daily
fluctuations
in
expression
levels,
making
circadian
rhythms
the
largest
known
regulatory
network
normal
physiology.
Cell-autonomous
clocks
interact
with
light-dark
and
feeding-fasting
cycles
to
generate
approximately
24-hour
oscillations
function
thousands
genes.
Circadian
secreted
molecules
signaling
components
transmits
timing
information
between
cells
tissues.
Such
intra-
intercellular
optimize
physiology
both
by
managing
energy
use
temporally
segregating
incompatible
processes.
Experimental
animal
models
epidemiological
data
indicate
that
chronic
rhythm
disruption
increases
risk
metabolic
diseases.
Conversely,
time-restricted
feeding,
which
imposes
feeding
fasting
without
caloric
reduction,
sustains
robust
diurnal
can
alleviate
These
findings
highlight
an
integrative
role
offer
a
new
perspective
for
treating
diseases
is
hallmark.
Science,
Journal Year:
2016,
Volume and Issue:
354(6315), P. 1004 - 1008
Published: Nov. 24, 2016
Disruptions
of
normal
circadian
rhythms
and
sleep
cycles
are
consequences
aging
can
profoundly
affect
health.
Accumulating
evidence
indicates
that
disturbances,
which
have
long
been
considered
symptoms
many
neurodegenerative
conditions,
may
actually
drive
pathogenesis
early
in
the
course
these
diseases.
In
this
Review,
we
explore
potential
cellular
molecular
mechanisms
linking
dysfunction
loss
to
diseases,
with
a
focus
on
Alzheimer’s
disease.
We
examine
interplay
between
central
peripheral
rhythms,
clock
gene
function,
maintaining
brain
homeostasis,
discuss
therapeutic
implications.
The
influence
number
key
processes
involved
neurodegeneration,
suggesting
systems
might
be
manipulated
promote
healthy
aging.
Proceedings of the National Academy of Sciences,
Journal Year:
2016,
Volume and Issue:
113(10)
Published: Feb. 8, 2016
Significance
Shift
work
is
a
risk
factor
for
hypertension,
inflammation,
and
cardiovascular
disease,
even
after
controlling
traditional
factors.
workers
frequently
undergo
circadian
misalignment
(i.e.,
between
the
endogenous
system
24-h
environmental/behavioral
cycles).
This
has
been
proposed
to
explain,
in
part,
why
shift
disease.
However,
impact
of
per
se
on
blood
pressure
inflammatory
markers
poorly
understood.
We
show—under
highly
controlled
laboratory
conditions—that
short-term
increases
healthy
adults.
Our
findings
may
help
explain
disease
risk.
Biology,
Journal Year:
2019,
Volume and Issue:
8(3), P. 54 - 54
Published: July 12, 2019
The
Munich
ChronoType
Questionnaire
(MCTQ)
has
now
been
available
for
more
than
15
years
and
its
original
publication
cited
1240
times
(Google
Scholar,
May
2019).
Additionally,
online
version,
which
was
until
July
2017,
produced
almost
300,000
entries
from
all
over
the
world
(MCTQ
database).
MCTQ
gone
through
several
versions,
translated
into
13
languages,
validated
against
other
objective
measures
of
daily
timing
in
independent
studies.
Besides
being
used
as
a
method
to
correlate
circadian
features
human
biology
with
factors—ranging
health
issues
geographical
factors—the
gave
rise
quantification
old
wisdoms,
like
“teenagers
are
late”,
new
concepts,
social
jetlag.
Some
MCTQ’s
simplicity
some
view
it
critically.
Therefore,
is
time
present
self-critical
on
MCTQ,
address
misunderstandings,
give
definitions
MCTQ-derived
chronotype
concept
