OncoImmunology, Journal Year: 2024, Volume and Issue: 13(1)
Published: Aug. 26, 2024
Disrupting mitochondrial function in malignant cells is a promising strategy to enhance anticancer immunity. We have recently demonstrated that depriving colorectal cancer of serine results dysfunction coupled with the cytosolic accumulation DNA and consequent activation CGAS- STING-dependent tumor-targeting immune responses.
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 684 - 684
Published: Jan. 15, 2025
Macular telangiectasia type 2 (MacTel) is a slowly progressive macular disorder that often diagnosed late due to the gradual onset of vision loss. Recent advances in diagnostic techniques have facilitated earlier detection and shown MacTel more common than initially thought. The disease genetically complex, multiple variants contribute incrementally overall risk. familial occurrence prompted investigation genetic background MacTel. To better understand molecular milieu disease, literature review clinical reports publications investigating factors was performed. date, disease-associated been found genes involved amino acid (glycine/serine) metabolism transport, urea cycle, lipid metabolism, retinal vasculature thickness. Variants implicated sphingolipid fatty acid/steroid/retinol patients with neurological disorders who also Retinal involves complex biochemical processes are essential for maintaining high energy requirements retina. Genetic alterations can disrupt key metabolic pathways, leading cell degradation subsequent loss characterizes several disorders, including This article summarizes findings may allow be further investigated as an inherited disorder.
Language: Английский
Citations
0
Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 86 - 86
Published: Feb. 1, 2025
Introduction and objective: This literature review aims to provide an overview of the progress in metabolomic assessment animal cell models humans with diabetic neuropathy (DN). Methods: Metabolomics has emerged as important approach for investigating, identifying, describing biomarkers related DN. None yet been validated use clinical practice. Results: DN induced significant alterations energy metabolism carbohydrates, lipids, amino acids, peptides, proteins. Several treatments DN, evaluated using metabolomics, were proved have promising results. Conclusions: The ideal metabolite or set metabolites that could be used should identify patients diabetes prone develop those severe forms sensory loss, associated risk ulcerations amputation. Another potential a might indicator treatment response trials agents disease-modifying properties.
Language: Английский
Citations
0
Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)
Published: Feb. 19, 2025
Abstract Background Cyclophosphamide (CTX) is the first-line medication for treatment of breast cancer, although it potentially leads to severe ovarian dysfunction and even premature failure (POF). However, mechanism CTX-induced POF remains unclear. Mesenchymal stem cell-based therapy has been wildly used treating numerous diseases. Therefore, our study aims elucidate underlying explore therapeutic effect human urine cells (hUSCs) in POF. Methods or granulosa cell (GCs) apoptosis were treated with hUSCs their exosomes vitro vivo. Morphological, histological, functional alternations examined using multiple approaches. The effector molecules hUSC-derived (hUSC-Exo) determined by differential expression analysis ovaries. target genes miRNA accessed transcriptome sequencing GCs, mechanisms further elucidated. Results remarkably inhibited promoted proliferation respectively. In addition, we observed that miR-27b-3p was highly expressed hUSC-Exo markedly suppressed GC specifically inhibiting SLC1A4, a serine transporter, which, turn, elevated concentration intracellular outflux cellular serine. More importantly, knockdown SLC1A4 simple supplementation GCs. Finally, demonstrated GCs essential reducing via elevating whereas protected against miR-27b-3p/SLC1A4/serine axis-mediated activation PI3K/AKT/mTOR signaling pathway. Conclusions Our suggests hUSC-based may provide an efficient approach prevention clinically. Graphical abstract
Language: Английский
Citations
0
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 18, 2025
Portable biosensors mainly focus on detecting biomarkers in biofluids but neglect the abundant skin stratum corneum, which are associated with functionality and integrity of barrier. Here, we propose a sensing patch designed for direct sampling situ quantification epidermal serine, an important biomarker healthcare. The consists porous hydrogel serine diffusion ion conduction, molecular imprinted polymer-based electrochemical sensor. By integrating customized handheld tester, system enables measurement levels. We demonstrate application this assessing moisturizing effect skincare product tracking recovery progress barrier function patient atopic dermatitis. Our work opens up potential scenario portable personalized Serine is authors introduce capable
Language: Английский
Citations
0
The Journal of Physical Chemistry A, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Aliphatic hydroxyamino acids, namely, α-hydroxyglycine, α-hydroxyalanine, serine, threonine, and homoserine, were studied by quantum chemical calculations using two methods in water as a solvent. A hybrid variant of DFT-B3LYP was applied to optimize the geometry neutral molecules, molecular cations, anions for canonical zwitterionic form amino acids. In energy minimum, vibrational analysis applied, enabling evaluation thermodynamic functions (internal energy, enthalpy, entropy, Gibbs energy) individual species absolute oxidation reduction potentials redox couples. B3LYP preoptimized geometry, advanced DLPNO-CCSD(T) method include major part interelectron correlation energy. Calculated descriptors compared with previously molecules same method, whole set 17 acids processed statistical such cluster principal component analysis. correlate adiabatic ionization energies along straight line, analogously, calculated potential correlates electrophilicity index. The α-amino is systematically influenced (reduced) functional groups hydroxyl, methyl, ethyl, iso-propyl; it decreases series α-, β-, γ-, δ-amino
Language: Английский
Citations
0
npj Aging, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 12, 2025
Increasing evidence suggests that frailty results from a complex age-associated metabolic decline. Here, we investigated the serum metabolomic profile of well-characterized cohort elderly subjects encompassing whole fit-to-frail continuum. Enrichment analyses revealed dysregulation amino acids and energy metabolism in both pre-frail frail participants. Remarkably, upregulated betaine levels emerged as specific biochemical signature females, holding promise for development novel targeted interventions.
Language: Английский
Citations
0
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: May 14, 2025
Objective Ultra-high-performance liquid chromatography-time-of-flight mass spectrometry (UHPLC-TOF-MS) was employed to analyze serum metabolites and metabolic pathways associated with syndrome (MS) in the Yi Han populations of Yunnan. Methods Participants included individuals diagnosed MS healthy controls from Serum nontargeted amino acid-targeted metabolomics analyses were conducted identify differential (DEMs) pathogenesis these two ethnic groups. Results Nontargeted analysis revealed 2,762 DEMs group population, while 1,535 identified population [variable importance projection (VIP)>1, P <0.05]. Venn highlighted common unique between populations. KEGG pathway seven significantly enriched five group, primarily involving acid synthesis metabolism. To investigate role acids MS, levels 71 endogenous quantified. In 19 identified, related D-glutamine D-glutamate metabolism, as well cysteine methionine six significant enrichment sulfur valine, leucine, isoleucine biosynthesis. Conclusion Our study investigates differences through targeted approaches, identifying both especially disorders, including glycine, serine, threonine which may play critical roles regulating different dysfunctions worth further exploration pathogenesis, might provide insights for effective prevention treatment various
Language: Английский
Citations
0
Metabolic Brain Disease, Journal Year: 2023, Volume and Issue: 39(1), P. 249 - 251
Published: Sept. 12, 2023
Language: Английский
Citations
7
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: unknown, P. 135789 - 135789
Published: Sept. 1, 2024
Language: Английский
Citations
2
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117216 - 117216
Published: Oct. 22, 2024
Language: Английский
Citations
2