Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer’s mouse model and stimulates synaptic plasticity pathway enzymes DOI Creative Commons
Jacopo Di Lucente,

Giuseppe Persico,

Zeyu Zhou

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Feb. 16, 2024

Abstract The Ketogenic Diet (KD) improves memory and longevity in aged C57BL/6 mice. We tested 7 months KD vs. control diet (CD) the mouse Alzheimer’s Disease (AD) model APP/PS1. significantly rescued Long-Term-Potentiation (LTP) to wild-type levels, not by changing Amyloid-β (Aβ) levels. KD’s ‘main actor’ is thought be Beta-Hydroxy-butyrate (BHB) whose levels rose CD mice, BHB itself LTP APP/PS1 hippocampi. 6 most significant pathways induced brains RNAseq all related Synaptic Plasticity. increases synaptic plasticity enzymes p-ERK p-CREB both sexes, of brain-derived neurotrophic factor (BDNF) females. suggest rescues through BHB’s enhancement plasticity. falls Mild-Cognitive Impairment (MCI) human AD. BHB, because they are an approved supplement respectively, may therapeutically translationally relevant MCI phase Disease.

Language: Английский

Beyond histone acetylation—writing and erasing histone acylations DOI
Shuai Zhao,

Xingrun Zhang,

Haitao Li

et al.

Current Opinion in Structural Biology, Journal Year: 2018, Volume and Issue: 53, P. 169 - 177

Published: Nov. 2, 2018

Language: Английский

Citations

175
The Potential Health Benefits of the Ketogenic Diet: A Narrative Review DOI Open Access

Kathryn Dowis,

Simran Banga

Nutrients, Journal Year: 2021, Volume and Issue: 13(5), P. 1654 - 1654

Published: May 13, 2021

Considering the lack of a comprehensive, multi-faceted overview ketogenic diet (KD) in relation to health issues, we compiled evidence related use its impact on microbiome, epigenome, diabetes, weight loss, cardiovascular health, and cancer. The KD could potentially increase genetic diversity microbiome ratio Bacteroidetes Firmicutes. epigenome might be positively affected by since it creates signaling molecule known as β-hydroxybutyrate (BHB). has helped patients with diabetes reduce their HbA1c need for insulin. There is suggest that can help visceral adiposity, appetite control. also suggests eating high-fat improves lipid profiles lowering low-density lipoprotein (LDL), increasing high-density (HDL), triglycerides (TG). Due Warburg effect, used an adjuvant treatment starve cancer cells, making them more vulnerable chemotherapy radiation. potential positive impacts each these areas warrant further analysis, improved studies, well-designed randomized controlled trials illuminate therapeutic possibilities provided this dietary intervention.

Language: Английский

Citations

152
Ketogenic Diets and Chronic Disease: Weighing the Benefits Against the Risks DOI Creative Commons

Lee Crosby,

Brenda Davis, Shivam Joshi

et al.

Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8

Published: July 16, 2021

Very-low-carbohydrate ketogenic diets have been long used to reduce seizure frequency and more recently promoted for a variety of health conditions, including obesity, diabetes, liver disease. Ketogenic may provide short-term improvement aid in symptom management some chronic diseases. Such affect diet quality, typically increasing intake foods linked disease risk decreasing found be protective epidemiological studies. This review examines the effects on common diseases, as well their impact quality possible risks associated with use. Given often-temporary improvements, unfavorable dietary intake, inadequate data demonstrating long-term safety, most individuals, outweigh benefits.

Language: Английский

Citations

152
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity DOI Creative Commons
Miyeko Mana,

Amanda M. Hussey,

Constantine N. Tzouanas

et al.

Cell Reports, Journal Year: 2021, Volume and Issue: 35(10), P. 109212 - 109212

Published: June 1, 2021

Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing intestinal stem cell (ISC) numbers, proliferation, function. Although PPAR (peroxisome proliferator-activated receptor) nuclear receptor activity has been proposed to facilitate these effects, their exact role unclear. Here we find that, loss-of-function vivo models, PPARα PPARδ contribute HFD response ISCs. Mechanistically, both PPARs do so robustly inducing downstream fatty acid oxidation (FAO) metabolic program. Pharmacologic genetic disruption of CPT1A (the rate-controlling enzyme mitochondrial FAO) blunts phenotype Furthermore, inhibition dampens pro-tumorigenic consequences on early tumor incidence progression. These findings demonstrate that HFD-activated FAO program creates therapeutic opportunity counter effects ISCs tumorigenesis.

Language: Английский

Citations

137
3-Hydroxybutyrate as a Metabolite and a Signal Molecule Regulating Processes of Living Organisms DOI Creative Commons
Justyna Mierziak, Marta Burgberger, Wioleta Wojtasik

et al.

Biomolecules, Journal Year: 2021, Volume and Issue: 11(3), P. 402 - 402

Published: March 9, 2021

3-hydroxybutyrate (3-HB) as a very important metabolite occurs in animals, bacteria and plants. It is well known that 3-HB formed product of the normal metabolism fatty acid oxidation can therefore be used an energy source absence sufficient blood glucose. In microorganisms, mainly serves substrate for synthesis polyhydroxybutyrate, which reserve material. Recent studies show plants, acts regulatory molecule most likely influences expression genes involved DNA methylation, thereby altering methylation levels. Additionally, not only intermediate metabolite, but also influence gene expression, lipid metabolism, neuronal function, overall metabolic rate. Some these effects are direct itself, while others indirect effects, regulated by metabolites into converted. One functions inhibition activity histone deacetylases thus epigenetic regulation many genes. Due to number this compound, it shows promising therapeutic properties.

Language: Английский

Citations

130
Diet and exercise in NAFLD/NASH: Beyond the obvious DOI
Georg Semmler, Christian Datz, Thomas Reiberger

et al.

Liver International, Journal Year: 2021, Volume and Issue: 41(10), P. 2249 - 2268

Published: July 30, 2021

Lifestyle represents the most relevant factor for non-alcoholic fatty liver disease (NAFLD) as hepatic manifestation of metabolic syndrome. Although a tremendous body clinical and preclinical data on effectiveness dietary lifestyle interventions exist, complexity this topic makes firm evidence-based recommendations nutrition exercise in NAFLD difficult. The aim review is to guide readers through labyrinth recent scientific findings diet steatohepatitis (NASH), summarizing "obvious" holistic manner simultaneously highlighting stimulating aspects translational research "beyond obvious". Specifically, importance calorie restriction regardless composition evidence from low-carbohydrate diets target incidence severity are discussed. aspect ketogenesis-potentially achieved via intermittent restriction-seems be central these warranting further investigation. Interactions with gut microbiota individual genetic background need comprehensively understood order develop personalized concepts strategies patients NAFLD/NASH.

Language: Английский

Citations

125
Cardiac mechanisms of the beneficial effects of SGLT2 inhibitors in heart failure: Evidence for potential off-target effects DOI Creative Commons
Jason R.B. Dyck, Samuel Sossalla, Nazha Hamdani

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2022, Volume and Issue: 167, P. 17 - 31

Published: March 21, 2022

Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute a promising drug treatment for heart failure patients with either preserved or reduced ejection fraction. Whereas SGLT2i were originally developed to target SGLT2 in the kidney facilitate glucosuria diabetic patients, it is becoming increasingly clear that these drugs also have important effects outside of kidney. In this review we summarize literature on cardiac SGLT2i, focussing pro-inflammatory and oxidative stress processes, ion transport mechanisms controlling sodium calcium homeostasis metabolic/mitochondrial pathways. These are particularly as disturbances pathways result endothelial dysfunction, diastolic stiffness, arrhythmias together contribute failure. We findings support concept directly beneficially interfere inflammation, stress, ionic homeostasis, metabolism within cell. However, given very low levels cells, evidence suggests SGLT2-independent class likely occurs via off-target myocardium. Thus, while there still much be understood about various factors which determine how affect research clearly demonstrates direct exist, albeit mediated pathways, may play role explaining beneficial

Language: Английский

Citations

109
The physiology of bilirubin: health and disease equilibrium DOI Creative Commons
Libor Vı́tek, Terry D. Hinds, David E. Stec

et al.

Trends in Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(4), P. 315 - 328

Published: Feb. 22, 2023

Language: Английский

Citations

81
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies DOI
Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma

et al.

Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662

Published: July 30, 2023

Language: Английский

Citations

80
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging DOI Creative Commons
Maria M. Mihaylova, Amandine Chaix, Mirela Delibegović

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(7), P. 1114 - 1131

Published: June 30, 2023

Language: Английский

Citations

50