International review of cell and molecular biology, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Journal of Internal Medicine, Journal Year: 2023, Volume and Issue: 295(4), P. 508 - 531
Published: Oct. 23, 2023
Abstract In recent decades, global life expectancies have risen significantly, accompanied by a marked increase in chronic diseases and population aging. This narrative review aims to summarize findings on the dietary factors influencing longevity, primarily from large cohort studies. First, maintaining healthy weight throughout is pivotal for aging mirroring benefits of lifelong, moderate calorie restriction today's obesogenic food environment. Second, specific types or sources fat, protein, carbohydrates are more important disease risk mortality than their quantity. Third, some traditional diets (e.g., Mediterranean, Nordic, Okinawa) contemporary patterns, such as plant‐based diet index, DASH (dietary approaches stop hypertension) diet, alternate eating been associated with lower longevity. These patterns share many common components predominance nutrient‐rich plant foods; limited red processed meats; culinary herbs spices prevalent cuisines) while embracing distinct elements different cultures. Fourth, combining other lifestyle could extend disease‐free 8–10 years. While adhering core principles diets, it crucial adapt recommendations individual preferences cultures well nutritional needs populations. Public health strategies should aim create healthier environment where nutritious options readily accessible, especially public institutions care facilities elderly. Although further mechanistic studies human trials needed better understand molecular effects aging, there pressing need establish maintain long‐term cohorts studying culturally diverse
Language: Английский
Citations
52
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(8), P. 1779 - 1794.e4
Published: July 25, 2024
Although fasting is increasingly applied for disease prevention and treatment, consensus on terminology lacking. Using Delphi methodology, an international, multidisciplinary panel of researchers clinicians standardized definitions various approaches in humans. Five online surveys a live conference were conducted with 38 experts, 25 whom completed all 5 surveys. Consensus was achieved the following terms: "fasting" (voluntary abstinence from some or foods beverages), "modified fasting" (restriction energy intake to max. 25% needs), "fluid-only fasting," "alternate-day "short-term (lasting 2-3 days), "prolonged (≥4 consecutive "religious fasting." "Intermittent (repetitive periods lasting ≤48 h), "time-restricted eating," "fasting-mimicking diet" discussed most. This study provides expert recommendations future research clinical applications, facilitating communication cross-referencing field.
Language: Английский
Citations
21
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(5), P. 893 - 911
Published: April 12, 2024
Language: Английский
Citations
14
New England Journal of Medicine, Journal Year: 2024, Volume and Issue: 390(14), P. 1299 - 1310
Published: April 10, 2024
Language: Английский
Citations
12
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 18, 2024
Abstract Dietary protein is a critical regulator of metabolic health and aging. Low diets are associated with healthy aging in humans, dietary restriction extends the lifespan healthspan mice. In this study, we examined effect (PR) on development progression Alzheimer’s disease (AD) 3xTg mouse model AD. Here, show that PR promotes leanness glycemic control mice, specifically rescuing glucose intolerance females. induces sex-specific alterations circulating brain metabolites, downregulating sphingolipid subclasses also reduces AD pathology mTORC1 activity, increases autophagy, improves cognition Finally, survival Our results suggest or pharmaceutical interventions mimic effects diet may hold promise as treatment for
Language: Английский
Citations
12
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 422 - 437.e8
Published: Feb. 1, 2024
Language: Английский
Citations
10
Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2025, Volume and Issue: 25(2), P. 206 - 212
Published: Jan. 16, 2025
The aim of the study was to assess occurrence sleep disorders and value body mass index in seniors, taking into account their quality aging participation classes at Universities Third Age (UTAs). involved 631 (100%) seniors from Silesian Voivodeship, aged 60 96 years (𝑥̅ = 70.28 ± 6.09 years). An original survey questionnaire used, supplemented by Successful Aging Scale Athens Insomnia questionnaires. median successful (SAI) points obtained UTAs "+" 11.71, while SAI "-" 11.18. Sleep were more common women than men as well among people 71-80 compared other groups. There statistically significant weak negative correlations between questionaire domains number value. abnormally increased weight associated with a deterioration studied seniors. Seniors participating activities had better who denied mentioned activity. Actions should be constantly taken improve process including providing them access contacts people, treating educating on benefits healthy lifestyle maintaining proper weight. Geriatr Gerontol Int 2025; 25: 206-212.
Language: Английский
Citations
1
Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 101, P. 101260 - 101260
Published: March 21, 2024
Language: Английский
Citations
6
Current Opinion in Oncology, Journal Year: 2024, Volume and Issue: 36(2), P. 82 - 92
Published: Jan. 17, 2024
Purpose of review This emphasizes the role epigenetic processes as incidental changes occurring during aging, which, in turn, promote development cancer. Recent findings Aging is a complex biological process associated with progressive deterioration normal physiological functions, making age significant risk factor for various disorders, including The increasing longevity population has made cancer global burden, developing most cancers increases due to cumulative effect exposure environmental carcinogens and DNA replication errors. classical ‘somatic mutation theory’ cause being challenged by observation that multiple cells harbor driver mutations without resulting In this review, we discuss age-associated alterations, methylation, which occur across all cell types tissues advancing age. There an body evidence linking these prognosis. Summary A better understanding about acquired aging critical comprehending mechanisms leading increase novel therapeutic strategies treatment prevention.
Language: Английский
Citations
4
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Abstract This study aims to explore the prevalence of Low-carbohydrate diet (LCD) among individuals with cardiovascular-kidney-metabolic (CKM) syndrome and its relationship prognosis. Methods The included diagnosed CKM from National Health Nutrition Examination Survey (NHANES) database between 2009 2018. Participants were divided into two groups: those on a LCD not LCD. Multivariate logistic regression analysis was conducted assess factors influencing choice individuals. Kaplan-Meier survival curve multivariate Cox performed evaluate association risk all-cause mortality. Stratified consistency results. Results A total 866 non-CKM (stage 0) 26,989 (stages 1, 2, 3, 4) included. proportions for stages 0, 4 2.07%, 0.59%, 1.25%, 2.42%, 1.59%, respectively. indicated that age, gender, race, body mass index, diabetes status might influence revealed compared non-LCD individuals, had 61% reduced mortality (HR=0.39; 95% CI, 0.22-0.71, P=0.002). showed no interaction (P <0.05). Conclusion proportion in is relatively low. Furthermore, can reduce regardless stage.
Language: Английский
Citations
0