The role of insufficient sleep and circadian misalignment in obesity

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 19(2), P. 82 - 97

Published: Oct. 24, 2022

Language: Английский

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Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 3934 - 3934

Published: Sept. 22, 2022

Melatonin has become a popular dietary supplement, most known as chronobiotic, and for establishing healthy sleep. Research over the last decade into cancer, Alzheimer’s disease, multiple sclerosis, fertility, PCOS, many other conditions, combined with COVID-19 pandemic, led to greater awareness of melatonin because its ability act potent antioxidant, immune-active agent, mitochondrial regulator. There are distinct similarities between vitamin D in depth breadth their impact on health. Both hormones, affect systems through immune-modulating, anti-inflammatory functions, found skin, responsive sunlight darkness. In fact, there may be widespread concern about deficiency “sunlight deficiency” reduced secretion result “darkness from overexposure artificial blue light. The trend toward use supplements resulted safety, especially higher doses, long-term use, application certain populations (e.g., children). This review aims evaluate recent data melatonin’s mechanisms, clinical uses beyond sleep, safety concerns, thorough summary therapeutic considerations concerning supplementation, including different formats available (animal, synthetic, phytomelatonin), dosing, timing, contraindications, nutrient combinations.

Language: Английский

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Mediterranean Diet on Sleep: A Health Alliance

Nutrients, Journal Year: 2022, Volume and Issue: 14(14), P. 2998 - 2998

Published: July 21, 2022

The Mediterranean diet is a plant-based, antioxidant-rich, unsaturated fat dietary pattern that has been consistently associated with lower rates of noncommunicable diseases and total mortality, so it considered one the healthiest patterns. Clinical trials mechanistic studies have demonstrated its peculiar foods nutrients exert beneficial effects against inflammation, oxidative stress, dysmetabolism, vascular dysfunction, adiposity, senescence, cognitive decline, neurodegeneration, tumorigenesis, thus preventing age-associated chronic improving wellbeing health. Nocturnal sleep an essential physiological function, whose alteration health outcomes diseases. Scientific evidence suggests are related in bidirectional relationship, understanding this association important given their role disease prevention. In review, we surveyed literature concerning current state from epidemiological on impact nighttime quantity quality. available indicate greater adherence to adequate duration several indicators better Potential mechanisms mediating effect described, gap-in-knowledge new research agenda corroborate findings discussed.

Language: Английский

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Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 138 - 138

Published: Jan. 11, 2024

A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, in contemporary society, there a prevalent occurrence misalignments system environmental cues, phenomenon frequently associated with adverse health consequences. The onset most current chronic diseases intimately connected alterations lifestyle practices under various facets, including following: reduced physical activity, exposure artificial light, also acknowledged as light pollution, sedentary behavior coupled consuming energy-dense nutriments, irregular eating frameworks, disruptions sleep patterns (inadequate quality duration), engagement shift work, known jetlag. rapid evolution life domestic routines has significantly outpaced rate genetic adaptation. Consequently, underlying rhythms exposed multiple shifts, thereby elevating susceptibility disease predisposition. comprehensive review endeavors synthesize existing empirical evidence that substantiates conceptual integration clock, biochemical molecular homeostasis, oxidative stress, stimuli imparted exercise, sleep, nutrition.

Language: Английский

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The Importance of Nutrition in Menopause and Perimenopause—A Review

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 27 - 27

Published: Dec. 21, 2023

Menopause is associated with an increased prevalence of obesity, metabolic syndrome, cardiovascular diseases, and osteoporosis. These diseases unfavorable laboratory values, which are characteristic this period in women, can be significantly improved by eliminating reducing dietary risk factors. Changing habits during perimenopause most effectively achieved through nutrition counseling intervention. To reduce the factors all these case already existing disease, therapy led a dietitian should integral part treatment. The following review summarizes recommendations for balanced diet fluid intake, prevention role sleep, key preventive nutrients menopause, such as vitamin D, calcium, C, B vitamins, protein intake. In summary, many lifestyle developing (cardiovascular insulin resistance, type 2 diabetes mellitus, osteoporosis, tumors) symptoms period.

Language: Английский

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Sleep quality in eating disorders: A systematic review and meta-analysis

Sleep Medicine Reviews, Journal Year: 2024, Volume and Issue: 77, P. 101969 - 101969

Published: June 18, 2024

Eating disorders (ED) are psychological characterized by dangerous eating behaviours, including protracted fasting and binge eating. Mental comorbidities (e.g., anxiety depression), as well sleep difficulties, common might interfere with treatment response. This work investigated quality, circadian preferences, in ED patients compared to healthy controls (HC) the impact of on patients' sleep. A literature search Pubmed, Web Science, Medline, PsychInfo included 27 studies. Random effect analyses were performed (sample = 711; sample 653) subgroup calculated based subgroups: Anorexia Nervosa, Bulimia Binge Disorder. Whole showed poorer physiological subjective quality patients. Subgroup that was present only anorexia nervosa. Two studies reporting preferences higher evening preference no differences apnea prevalence between controls, respectively. Some suggested specialized disorder treatments Cognitive Behavioural Therapy for ED) can improve Although these findings highlight mechanisms underlying alterations remain be identified.

Language: Английский

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Acute and chronic effects of physical exercise on atherosclerosis, kynurenine pathway, endothelial function and inflammation in patients with coronary artery disease: a clinical trial protocol

BMJ Open Sport & Exercise Medicine, Journal Year: 2025, Volume and Issue: 11(1), P. e002432 - e002432

Published: Feb. 1, 2025

Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with CAD exhibit increased levels kynurenine (KYN) pathway (KP) metabolites, which are key products tryptophan (TRP) catabolism and have been identified as predictive markers for cardiovascular events atherosclerosis progression. However, effects exercise on KP metabolites their influence inflammation in these patients remain poorly understood. We aim to investigate exercise’s acute chronic carotid intima-media thickness, inflammatory plasma-soluble adhesion molecules CAD. aged 40–70 will undergo training (three times per week 12 weeks ). A healthy reference group also be included. Evaluations occur at baseline post-intervention. On first visit, thickness assessed via ultrasound before after cardiopulmonary testing. The second visit include an endothelial function evaluation using venous occlusion plethysmography 30 min moderate-intensity aerobic exercise. Blood samples collected pre-exercise post-exercise. Levels (TRP, KYN, kynurenic acid quinolinic acid), cytokines (interleukin-6, tumour necrosis factor-alpha interferon-gamma), T-cell subpopulations soluble (soluble P-selectin, vascular cell molecule-1 intercellular molecule-1) ELISA, flow cytometry multiplex assays, respectively. This study was approved by Ethics Committee Pedro Ernesto University Hospital (CAAE 81718324.3.0000.5259) registered ClinicalTrials.gov ( NCT06579807 Dissemination findings peer-reviewed publications, conference presentations media releases.

Language: Английский

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Not All Workers Experience Equal Sleep Changes: Insights from the “WorkInCovid” Project

Clocks & Sleep, Journal Year: 2025, Volume and Issue: 7(1), P. 13 - 13

Published: March 10, 2025

The COVID-19 outbreak has changed work organization in favor of a working from home (WH) modality. We examined the association WH during pandemic with sleep health workers public research organization. An online cross-sectional survey 2022 at National Research Council Italy collected information on sociodemographics, characteristics, and pattern compared before WH. In whole sample (n = 748), total quality did not significantly change. Excessive daytime sleepiness (EDS) decreased Total increased poor sleepers, while it good sleepers. morning chronotype was protective against worsening Risk factors were depression body weight gain These findings emphasize importance baseline shaping impact sleep.

Language: Английский

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The Longitudinal Interplay between Sleep, Anthropometric Indices, Eating Behaviors, and Nutritional Aspects: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3179 - 3179

Published: July 18, 2023

Sleep is fundamental for adolescents' healthy development but undergoes dramatic changes in quantity and quality due to the conflict between biological social rhythms. Insufficient sleep has been associated with worse physical health status irregular eating behaviors adolescents. This review aims systematically synthesize longitudinal associations dimensions (i.e., duration, timing, quality, insomnia symptoms) indicators anthropometric indices, fat percentage, risk of obesity), behaviors, nutritional aspects type diet related intake specific foods nutrients, amount timing food consumption, energy expenditure). A total 28 studies were included. The meta-analytic results showed that longer better lower symptoms BMI percentage shorter duration (<7 h) a higher obesity. Conversely, indices not over time. Limited literature examined bidirectional association their aspects. Such knowledge sheds new light on role health, highlighting need examine further interplay these variables.

Language: Английский

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Healthier Dietary Patterns Are Associated with Better Sleep Quality among Shanghai Suburban Adults: A Cross-Sectional Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1165 - 1165

Published: April 13, 2024

More is to be explored between dietary patterns and sleep quality in the Chinese adult population.

Language: Английский

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