Critical Care,
Journal Year:
2021,
Volume and Issue:
25(1)
Published: April 26, 2021
Abstract
Background
COVID-19
has
resulted
in
high
mortality
worldwide.
Information
regarding
cardiac
markers
for
precise
risk-stratification
is
limited.
We
aim
to
discover
sensitive
and
reliable
early-warning
biomarkers
optimizing
management
improving
the
prognosis
of
patients.
Methods
A
total
2954
consecutive
patients
who
were
receiving
treatment
from
Wuhan
Huoshenshan
Hospital
China
February
4
April
10
included
this
retrospective
cohort.
Serum
levels
collected
after
admission.
Coronary
artery
disease
diagnosis
survival
status
recorded.
Single-cell
RNA-sequencing
bulk
different
cohorts
non-COVID-19
performed
analyze
SARS-CoV-2
receptor
expression.
Results
Among
analysis,
median
age
was
60
years
(50–68
years),
1461
(49.5%)
female,
1515
(51.3%)
severe/critical.
Compared
mild/moderate
(1439,
48.7%)
patients,
severe/critical
showed
significantly
higher
within
first
week
In
those
with
abnormal
serum
BNP
(42
[24.6%]
vs
7
[1.1%]),
hs-TNI
(38
[48.1%]
6
[1.0%]),
α-
HBDH
(55
[10.4%]
2
[0.2%]),
CK-MB
(45
[36.3%]
12
[0.9%]),
LDH
(56
[12.5%]
1
[0.1%])
had
a
rate
compared
normal
levels.
The
same
trend
observed
ICU
admission
rate.
Severe/critical
pre-existing
coronary
(165/1,155
[10.9%])
more
cases
(52
[46.5%]
119
[16.5%]),
(24
[26.7%]
9.6
[%],
(86
[55.5%]
443
[34.4%]),
(27
[17.4%]
97
[7.5%]),
(65
[41.9%]
382
[29.7%]),
when
without
disease.
There
enhanced
expression
healthy
controls.
From
regression
five
elevated
at
risk
death
(hazards
ratio
3.4
[95%
CI
2.4–4.8]).
Conclusions
represented
percentage
markers,
accompanied
by
together
hs-TNI,
HBDH,
act
as
prognostic
biomarker
or
Biomarker Research,
Journal Year:
2021,
Volume and Issue:
9(1)
Published: March 12, 2021
miRNA-21
is
among
the
most
abundant
and
highly
conserved
microRNAs
(miRNAs)
recognized.
It
expressed
in
essentially
all
cells
where
it
performs
vital
regulatory
roles
health
disease.
also
frequently
claimed
to
be
a
biomarker
of
diseases
such
as
cancer
heart
disease
bodily-fluid
based
miRNA
studies.
Here
we
dissociate
its
contributions
cellular
physiology
pathology
from
potential
biomarker.
We
show
how
has
been
specific
predictive
or
prognostic
by
at
least
29
diseases.
Thus,
no
specificity
any
one
As
result,
should
not
considered
viable
candidate
biomarker,
despite
continued
evaluation
such.
This
theme
multiple
assignments
shared
with
other
common,
ubiquitous
miRNAs
concerning
for
them
well.
New England Journal of Medicine,
Journal Year:
2021,
Volume and Issue:
384(21), P. 2014 - 2027
Published: May 26, 2021
The
diagnosis
of
acute
myocarditis
typically
requires
either
endomyocardial
biopsy
(which
is
invasive)
or
cardiovascular
magnetic
resonance
imaging
not
universally
available).
Additional
approaches
to
are
desirable.
We
sought
identify
a
novel
microRNA
for
the
myocarditis.To
specific
myocarditis,
we
performed
microarray
analyses
and
quantitative
polymerase-chain-reaction
(qPCR)
assays
in
sorted
CD4+
T
cells
type
17
helper
(Th17)
after
inducing
experimental
autoimmune
myocardial
infarction
mice.
also
qPCR
samples
from
coxsackievirus-induced
then
identified
human
homologue
this
compared
its
expression
plasma
obtained
patients
with
various
controls.We
confirmed
that
Th17
cells,
which
characterized
by
production
interleukin-17,
characteristic
feature
injury
phase
myocarditis.
mmu-miR-721
was
synthesized
present
mice
viral
but
those
infarction.
homologue,
designated
hsa-miR-Chr8:96,
four
independent
cohorts
area
under
receiver-operating-characteristic
curve
distinguishing
0.927
(95%
confidence
interval,
0.879
0.975).
retained
diagnostic
value
models
adjustment
age,
sex,
ejection
fraction,
serum
troponin
level.After
identifying
humans
found
(hsa-miR-Chr8:96)
could
be
used
distinguish
(Funded
Spanish
Ministry
Science
Innovation
others.).
Journal of Clinical Investigation,
Journal Year:
2022,
Volume and Issue:
132(11)
Published: May 31, 2022
The
discovery
of
microRNAs
and
their
role
in
diseases
was
a
breakthrough
that
inspired
research
into
as
drug
targets.
Cardiovascular
are
an
area
which
limitations
conventional
pharmacotherapy
highly
apparent
where
microRNA-based
drugs
have
appreciably
progressed
preclinical
clinical
testing.
In
this
Review,
we
summarize
the
current
state
therapeutic
targets
cardiovascular
system.
We
report
recent
advances
identification
characterization
microRNAs,
manipulation
translation,
discuss
challenges
perspectives
toward
application.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(5), P. 1799 - 1799
Published: Feb. 23, 2023
Cardiac
diseases
form
the
lion’s
share
of
global
disease
burden,
owing
to
paradigm
shift
non-infectious
from
infectious
ones.
The
prevalence
CVDs
has
nearly
doubled,
increasing
271
million
in
1990
523
2019.
Additionally,
trend
for
years
lived
with
disability
17.7
34.4
over
same
period.
advent
precision
medicine
cardiology
ignited
new
possibilities
individually
personalized,
integrative,
and
patient-centric
approaches
prevention
treatment,
incorporating
standard
clinical
data
advanced
“omics”.
These
help
phenotypically
adjudicated
individualization
treatment.
major
objective
this
review
was
compile
evolving
clinically
relevant
tools
that
can
evidence-based
precise
individualized
management
cardiac
highest
DALY.
field
is
provide
targeted
therapy,
which
crafted
as
per
“omics”,
involving
genomics,
transcriptomics,
epigenomics,
proteomics,
metabolomics,
microbiomics,
deep
phenotyping.
Research
individualizing
therapy
heart
DALY
helped
identify
novel
genes,
biomarkers,
proteins,
technologies
aid
early
diagnosis
Precision
management,
allowing
diagnosis,
timely
intervention,
exposure
minimal
side
effects.
Despite
these
great
impacts,
overcoming
barriers
implementing
requires
addressing
economic,
cultural,
technical,
socio-political
issues.
proposed
be
future
cardiovascular
holds
potential
a
more
efficient
personalized
approach
diseases,
contrary
standardized
blanket
approach.
Journal of Cellular and Molecular Medicine,
Journal Year:
2019,
Volume and Issue:
23(9), P. 6005 - 6016
Published: June 26, 2019
Abstract
MicroRNAs
(miRNAs)
are
strongly
up‐regulated
under
pathological
stress
and
in
a
wide
range
of
diseases.
In
recent
years,
miRNAs
investigation
for
their
potential
use
as
biomarkers
cardiovascular
We
investigate
whether
specific
cardio‐miRNAs
overexpressed
heart
samples
from
subjects
deceased
acute
myocardial
infarction
(AMI)
or
sudden
cardiac
death
(SCD),
miRNA
could
help
differentiate
between
them.
Forty
four
cases
due
to
disease
were
selected,
respectively,
19
categorized
AMI
25
SCD.
Eighteen
traumatic
without
involvement
selected
control.
Immunohistochemical
was
performed
CD15,
IL‐15,
Cx43,
MCP‐1,
tryptase,
troponin
C
I.
Reverse
transcription
quantitative
real‐time
PCR
miR‐1,
miR‐133,
miR‐208
miR‐499.
group,
stronger
immunoreaction
the
IL‐15
MCP‐1
antibodies
detectable
compared
with
SCD
Cx43
showed
negative
reaction
respect
other
groups.
Real‐time
results
down‐regulation
all
group
The
presented
high
accuracy
discriminating
(miR‐1
miR‐499)
control
(miR‐208)
representing
aid
both
clinicians
pathologists
differential
diagnosis.
Frontiers in Physiology,
Journal Year:
2020,
Volume and Issue:
11
Published: July 7, 2020
MicroRNAs
(miRNAs)
are
short
sequences
of
non-coding
RNA
that
play
an
important
role
in
the
regulation
gene
expression
and
thereby
many
physiological
pathological
processes.
Furthermore,
miRNAs
released
extracellular
space,
for
example
vesicles,
detectable
various
biological
fluids,
such
as
serum,
plasma,
urine.
Over
last
years,
it
has
been
shown
crucial
development
several
cardiovascular
diseases
(CVDs).
This
review
discusses
(patho)physiological
implications
CVD,
ranging
from
risk
factors
(i.e.,
hypertension,
diabetes,
dyslipidemia),
to
atherosclerosis,
myocardial
infarction,
cardiac
remodeling.
Moreover,
intriguing
possibility
their
use
disease-specific
diagnostic
prognostic
biomarkers
human
CVDs
will
be
discussed
detail.
Finally,
approaches
have
developed
alter
miRNA
function
mimics,
antagomirs,
target-site
blockers),
we
highlight
with
most
promising
therapeutic
potential
may
represent
suitable
candidates
intervention
future
translational
studies
ultimately
clinical
trials.
All
all,
this
gives
a
comprehensive
overview
relevant
CVD
even
targets.
International Journal of Biological Sciences,
Journal Year:
2021,
Volume and Issue:
17(3), P. 712 - 727
Published: Jan. 1, 2021
Tight
junction
(TJ)
is
a
"zippering
up"
structure
located
at
the
uppermost
portion
of
adjacent
epithelial/endothelial
cells
in
organs
and
tissues.TJs
maintain
relative
stability
intracellular
substances
functions
by
closing
or
opening
intercellular
pathways,
coordinating
entry
exit
molecules
different
sizes
charges,
regulating
permeability
paracellular
barrier.TJs
also
prevent
microbial
invasion,
cell
polarity,
regulate
proliferation.TJs
are
widely
present
skin
mucosal
epithelial
barriers,
intestinal
barrier,
glomerular
filtration
bladder
blood-brain
brain-blood
tumor
blood-testis
barrier.TJ
dysfunction
can
lead
to
variety
diseases.In
addition
signal
transcription
factors,
DNA
methylation,
histone
modification,
TJ
proteins
be
regulated
non-coding
RNAs,
such
as
micro-RNAs,
long-noncoding
circular
directly
indirectly.This
review
summarizes
TJs
introduces
regulatory
mechanisms
tissues.The
roles
RNAs
regulation
highlighted
this
review.
Non-coding RNA Research,
Journal Year:
2022,
Volume and Issue:
7(1), P. 7 - 15
Published: Jan. 14, 2022
The
field
of
extracellular
vesicles
has
been
rapidly
developing
after
it
became
evident
that
a
defined
subset
vesicles,
called
exosomes,
can
modulate
several
biological
functions
in
distant
cells
and
tissues.
Exosomes
range
size
from
40
to
160
nm
diameter,
are
released
by
majority
our
body,
carry
molecules
which
reflect
the
cell
origin.
types
biomolecules
packed,
their
respective
purpose,
impact
on
physiological
state
distinct
tissues
should
be
understood
advance
using
exosomes
as
biomarkers
health
disease.
Many
such
effects
linked
exosomal
RNA
include
both
coding
non-coding
RNAs.
role(s)
various
RNAs
have
started
being
recognized
sequencing
methods
widely
available
led
discovery
variety
roles
regulating
many
processes
beginning
unraveled.
In
present
review,
we
outline
discuss
recent
progress
elucidation
driven
relevance
for
major
conditions
including
disorders
central
nervous
system,
cardiovascular
metabolism,
cancer,
immune
system.
Furthermore,
also
potential
use
valuable
therapeutics
tissue
regeneration
resulting
excessive
inflammation.
While
exosome
research
is
still
its
infancy,
in-depth
understanding
formation,
effects,
specific
cell-targeting
will
uncover
how
they
used
disease
therapeutics.
