Terapevticheskii arkhiv,
Journal Year:
2025,
Volume and Issue:
97(04), P. 353 - 359
Published: May 8, 2025
Cardiac-specific
(or
myomiR)
miRNA-499a
(miR-499a)
is
a
small
(21–22
bp)
non-coding
RNA
that
involved
in
the
regulation
of
cardiac
function
both
under
normal
and
various
pathological
conditions.
Every
year
new
studies
expand
range
known
biological
processes
are
regulated
by
miR-499a
heart.
In
acute
chronic
cardiovascular
diseases
accompanied
cardiomyocyte
damage,
enters
bloodstream
can
circulate
there
for
long
time.
At
same
time,
it
detected
plasma
significantly
earlier
than
traditional
protein
biomarkers,
which
makes
promising
biomarker
early
diagnosis
prognosis
heart
diseases.
This
review
describes
functions
human
its
involvement
development
The
data
indicating
high
diagnostic
value
this
miRNA
blood
presented.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(3), P. 700 - 700
Published: Jan. 21, 2020
The
interest
in
non-coding
RNAs,
which
started
more
than
a
decade
ago,
has
still
not
weakened.
A
wealth
of
experimental
and
clinical
studies
suggested
the
potential
especially
short-sized
microRNAs
(miRs),
to
be
used
as
new
generation
therapeutic
targets
biomarkers
cardiovascular
disease,
an
ever-growing
public
health
issue
modern
world.
Among
hundreds
miRs
characterized
so
far,
microRNA-1
(miR-1)
microRNA-21
(miR-21)
have
received
some
attention
been
associated
with
cardiac
injury
cardioprotection.
In
this
review
article,
we
summarize
current
knowledge
function
these
two
heart,
their
association
injury,
cardioprotective
roles
biomarker
value.
While
field
already
extensively
studied,
much
remains
done
before
research
findings
can
translated
into
application
for
patient’s
benefit.
Journal of Cellular and Molecular Medicine,
Journal Year:
2019,
Volume and Issue:
23(9), P. 6005 - 6016
Published: June 26, 2019
Abstract
MicroRNAs
(miRNAs)
are
strongly
up‐regulated
under
pathological
stress
and
in
a
wide
range
of
diseases.
In
recent
years,
miRNAs
investigation
for
their
potential
use
as
biomarkers
cardiovascular
We
investigate
whether
specific
cardio‐miRNAs
overexpressed
heart
samples
from
subjects
deceased
acute
myocardial
infarction
(AMI)
or
sudden
cardiac
death
(SCD),
miRNA
could
help
differentiate
between
them.
Forty
four
cases
due
to
disease
were
selected,
respectively,
19
categorized
AMI
25
SCD.
Eighteen
traumatic
without
involvement
selected
control.
Immunohistochemical
was
performed
CD15,
IL‐15,
Cx43,
MCP‐1,
tryptase,
troponin
C
I.
Reverse
transcription
quantitative
real‐time
PCR
miR‐1,
miR‐133,
miR‐208
miR‐499.
group,
stronger
immunoreaction
the
IL‐15
MCP‐1
antibodies
detectable
compared
with
SCD
Cx43
showed
negative
reaction
respect
other
groups.
Real‐time
results
down‐regulation
all
group
The
presented
high
accuracy
discriminating
(miR‐1
miR‐499)
control
(miR‐208)
representing
aid
both
clinicians
pathologists
differential
diagnosis.
Frontiers in Cardiovascular Medicine,
Journal Year:
2021,
Volume and Issue:
7
Published: Feb. 3, 2021
The
incidence
of
myocardial
infarction
(MI)
increases
every
year
worldwide.
Better
diagnostic
and
prognostic
biomarkers
for
clinical
applications
are
the
consistent
pursuit
MI
research.
In
addition
to
electrocardiogram,
echocardiography,
coronary
angiography,
etc.,
circulating
essential
diagnosis,
prognosis,
treatment
effect
monitoring
patients.
this
review,
we
assessed
both
strength
weakness
including:
(1)
originated
from
damaged
tissues
including
current
golden
standard
cardiac
troponin,
(2)
released
non-myocardial
due
MI-induced
systems
reactions,
(3)
preexisted
in
blood
circulation
before
occurrence
event.
We
also
summarized
newly
reported
biomarkers.
proposed
that
preexisting
incidents
should
be
emphasized
research
development
prevention
near
future.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5192 - 5192
Published: March 8, 2023
MicroRNAs
(miRNAs),
small
noncoding
RNAs,
are
post-transcriptional
gene
regulators
that
can
promote
the
degradation
or
decay
of
coding
mRNAs,
regulating
protein
synthesis.
Many
experimental
studies
have
contributed
to
clarifying
functions
several
miRNAs
involved
in
regulatory
processes
at
cardiac
level,
playing
a
pivotal
role
cardiovascular
disease
(CVD).
This
review
aims
provide
an
up-to-date
overview,
with
focus
on
past
5
years,
human
samples
present
clear
background
latest
advances
summarize
current
knowledge
and
future
perspectives.
SCOPUS
Web
Science
were
searched
using
following
keywords:
(miRNA
microRNA)
AND
(cardiovascular
diseases);
(myocardial
infarction);
(heart
damage);
failure),
including
published
from
1
January
2018
31
December
2022.
After
accurate
evaluation,
59
articles
included
systematic
review.
While
it
is
powerful
regulators,
all
underlying
mechanisms
remain
unclear.
The
need
for
data
always
justifies
enormous
amount
scientific
work
increasingly
highlight
their
pathways.
Given
importance
CVDs,
could
be
important
both
as
diagnostic
therapeutic
(theranostic)
tools.
In
this
context,
discovery
“TheranoMIRNAs”
decisive
near
future.
definition
well-setout
necessary
further
evidence
challenging
field.
Frontiers in Cardiovascular Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: Oct. 30, 2023
Myocardial
infarction
(MI)
is
a
prevalent
cardiovascular
disease
characterized
by
myocardial
necrosis
resulting
from
coronary
artery
ischemia
and
hypoxia,
which
can
lead
to
severe
complications
such
as
arrhythmia,
cardiac
rupture,
heart
failure,
sudden
death.
Despite
being
research
hotspot,
the
etiological
mechanism
of
MI
remains
unclear.
The
emergence
widespread
use
omics
technologies,
including
genomics,
transcriptomics,
proteomics,
metabolomics,
other
omics,
have
provided
new
opportunities
for
exploring
molecular
identifying
large
number
biomarkers.
However,
single-omics
approach
has
limitations
in
understanding
complex
biological
pathways
diseases.
multi-omics
reveal
interaction
network
among
molecules
at
various
levels
overcome
approaches.
This
review
focuses
on
studies
MI,
epigenomics,
omics.
exploration
extended
into
domain
integrative
analysis,
accompanied
compilation
diverse
online
resources,
databases,
tools
conducive
these
investigations.
Additionally,
we
discussed
role
prospects
approaches
personalized
medicine,
highlighting
potential
improving
diagnosis,
treatment,
prognosis
MI.
Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2018,
Volume and Issue:
14(1), P. 211 - 238
Published: Oct. 17, 2018
Cardiovascular
diseases
exist
across
all
developed
countries.
Biomarkers
that
can
predict
or
diagnose
early
in
their
pathogeneses
reduce
morbidity
and
mortality
afflicted
individuals.
microRNAs
are
small
regulatory
RNAs
modulate
translation
have
been
identified
as
potential
fluid-based
biomarkers
numerous
maladies.
We
describe
the
current
state
of
cardiovascular
disease
a
range
diseases,
including
myocardial
infarction,
acute
coronary
syndrome,
myocarditis,
hypertension,
heart
failure,
transplantation,
aortic
stenosis,
diabetic
cardiomyopathy,
atrial
fibrillation,
sepsis.
present
understanding
possible
these
categories
where
best
opportunities
to
enter
clinical
practice.
Biomedicine & Pharmacotherapy,
Journal Year:
2020,
Volume and Issue:
132, P. 110903 - 110903
Published: Oct. 20, 2020
MicroRNA-1
(miR-1)
is
a
conserved
miRNA
with
high
expression
in
the
muscle
tissues.
In
humans,
two
discrete
genes,
MIRN1-1
and
MIRN1-2
residing
on
genomic
region
18q11.2
produce
single
mature
which
has
21
nucleotides.
miR-1
regulatory
role
number
of
genes
including
heat
shock
protein
60
(HSP60),
Kruppel-like
factor
4
(KLF4)
Heart
And
Neural
Crest
Derivatives
Expressed
2
(HAND2).
critical
roles
physiological
processes
smooth
skeletal
muscles
as
well
other
tissues,
thus
being
involved
pathogenesis
wide
range
disorders.
Moreover,
dysregulation
been
noted
diverse
types
cancers
gastric,
colorectal,
breast,
prostate
lung
cancer.
current
review,
we
provide
summary
data
regarding
this
normal
development
pathogenic
processes.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(3), P. 1512 - 1512
Published: Jan. 28, 2022
Coronary
artery
disease
remains
the
leading
cause
of
death.
Acute
myocardial
infarction
(MI)
is
characterized
by
decreased
blood
flow
to
coronary
arteries,
resulting
in
cardiomyocytes
The
most
effective
strategy
for
treating
an
MI
early
and
rapid
reperfusion,
but
restoring
ischemic
myocardium
can
induce
further
damage,
known
as
ischemia-reperfusion
(IR)
injury.
Novel
therapeutic
strategies
are
critical
limit
IR
injury
improve
patient
outcomes
following
reperfusion
intervention.
miRNAs
small
non-coding
RNA
molecules
that
have
been
implicated
attenuating
pathology
pre-clinical
rodent
models.
In
this
review,
we
discuss
role
miR-1
miR-21
regulating
apoptosis
whole
heart
well
different
cardiac
cell
types
with
special
emphasis
on
cardiomyocytes,
fibroblasts,
immune
cells.
We
also
examine
potential
preclinical
studies.
More
research
necessary
understand
cell-specific
molecular
principles
cardioprotection
application
acute
