Pathology, Journal Year: 2023, Volume and Issue: 56(1), P. 1 - 10
Published: Nov. 23, 2023
Language: Английский
ACS Nano, Journal Year: 2022, Volume and Issue: 16(11), P. 17802 - 17846
Published: Nov. 10, 2022
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by lipid bilayer membrane and secreted most eukaryotic cells. They represent route intercellular communication participate in wide variety physiological pathological processes. The biological roles exosomes rely on their bioactive cargos, including proteins, nucleic acids, lipids, which delivered to target Their distinctive properties─innate stability, low immunogenicity, biocompatibility, good biomembrane penetration capacity─allow them function as superior natural nanocarriers for efficient drug delivery. Another notably favorable clinical application is diagnostics. hold various biomolecules from host cells, indicative pathophysiological conditions; therefore, they considered vital biomarker discovery Here, we use data the CAS Content Collection provide landscape overview current state delineate trends research advancement exosome applications therapeutics diagnostics across time, geography, composition, cargo loading, development pipelines. We discuss composition pathway, biogenesis secretion cells recipient cell uptake. assess methods isolation purification, therapy diagnostics, pipelines, exploration goals companies, assortment diseases aim treat, stages research, publication trends. hope this review will be useful understanding knowledge field medical exosomes, an effort further solve remaining challenges fulfilling potential.
Language: Английский
Citations
337
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13
Published: Jan. 18, 2023
Ovarian cancer is a malignant tumor of the female reproductive system, with very poor prognosis and high mortality rates. Chemotherapy radiotherapy are most common treatments for ovarian cancer, unsatisfactory results. Exosomes subpopulation extracellular vesicles, which have diameter approximately 30–100 nm secreted by many different types cells in various body fluids. highly stable effective carriers immunotherapeutic drugs. Recent studies shown that exosomes involved cellular responses microenvironment, influencing development therapeutic efficacy exhibiting dual roles inhibiting promoting development. also contain variety genes related to immunotherapy could be potential biomarkers diagnosis prognosis. Undoubtedly, great field immunotherapy. However, translation this idea clinic has not occurred. Therefore, it important understand how used regulate progression. In review, we summarize fluids mechanisms influence response. We discuss prospects clinical application exosome-based cancer.
Language: Английский
Citations
58
Molecular Therapy, Journal Year: 2024, Volume and Issue: 32(9), P. 2939 - 2949
Published: Feb. 27, 2024
Language: Английский
Citations
42
Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)
Published: June 14, 2024
Abstract In recent decades, research on Extracellular Vesicles (EVs) has gained prominence in the life sciences due to their critical roles both health and disease states, offering promising applications diagnosis, drug delivery, therapy. However, inherent heterogeneity complex origins pose significant challenges preparation, analysis, subsequent clinical application. This review is structured provide an overview of biogenesis, composition, various sources EVs, thereby laying groundwork for a detailed discussion contemporary techniques preparation analysis. Particular focus given state‐of‐the‐art technologies that employ microfluidic non‐microfluidic platforms EV processing. Furthermore, this discourse extends into innovative approaches incorporate artificial intelligence cutting‐edge electrochemical sensors, with particular emphasis single proposes current outlines prospective avenues future research. The objective motivate researchers innovate expand methods analysis fully unlocking biomedical potential.
Language: Английский
Citations
39
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 2, 2024
Abstract Neurodegenerative disorders are complex, progressive, and life-threatening. They cause mortality disability for millions of people worldwide. Appropriate treatment neurodegenerative diseases (NDs) is still clinically lacking due to the presence blood-brain barrier (BBB). Developing an effective transport system that can cross BBB enhance therapeutic effect neuroprotective agents has been a major challenge NDs. Exosomes endogenous nano-sized vesicles naturally carry biomolecular cargoes. Many studies have indicated exosome content, particularly microRNAs (miRNAs), possess biological activities by targeting several signaling pathways involved in apoptosis, inflammation, autophagy, oxidative stress. Exosome content influence cellular function healthy or pathological ways. Furthermore, since exosomes reflect features parental cells, their cargoes offer opportunities early diagnosis intervention diseases. unique characteristics make them ideal delivering drugs directly brain. These include ability pass through BBB, biocompatibility, stability, innate properties. This review emphasizes role alleviating NDs discusses associated molecular mechanisms. exosomes, making promising natural transporter various medications brain combat NDs, also discussed.
Language: Английский
Citations
32
Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)
Published: Jan. 9, 2024
Language: Английский
Citations
22
Lab on a Chip, Journal Year: 2023, Volume and Issue: 23(13), P. 2942 - 2958
Published: Jan. 1, 2023
This critical review addresses recent developments in integrated microfluidic technologies for cancer detection with an emphasis on three common subtypes of biomarkers: circulating tumor cells, DNA and exosomes.
Language: Английский
Citations
35
Texas Heart Institute Journal, Journal Year: 2023, Volume and Issue: 50(5)
Published: Oct. 16, 2023
Cardiovascular disease is the leading cause of death and disability worldwide. Early detection treatment cardiovascular are crucial for patient survival long-term health. Despite advances in biomarkers, prevalence continues to increase worldwide as global population ages. To address this problem, novel biomarkers that more sensitive specific diseases must be developed incorporated into clinical practice. Exosomes promising disease. These small vesicles produced released body fluids by all cells carry information can correlated with progression. This article reviews advantages limitations existing disease, such cardiac troponin cytokines, discusses recent evidence suggesting promise exosomes biomarkers.
Language: Английский
Citations
25
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171774 - 171774
Published: March 18, 2024
Language: Английский
Citations
16
View, Journal Year: 2023, Volume and Issue: 4(2)
Published: Jan. 16, 2023
Abstract Exosomes are extracellular vesicles that actively secreted by most live cells via endosome pathway. They distribute ubiquitously in body fluids and play important roles physiological pathological processes. Recent studies have revealed exosomes carry cell‐specific cargoes, such as proteins nucleic acids, which been recognized emerging noninvasive biomarkers liquid biopsy. Therefore, the molecular profiling of tumor‐derived is crucial facilitating discovery cancer‐related biomarkers. Recently, various techniques proposed for sensitive, accurate, rapid characterization these small vesicles. To meet growing demands multiplexed detection, microfluidics has integrated with diverse traditional analytical methods powerful components analysis. Taking advantages their inherent merits great sensitivity, high analysis performance system integration, short time, low cost, volume sample, improved potential control, automation, disposability, microfluidic systems significantly exosomes. In this review, we summarized recent progresses technologies exosomes, including proteins, metabolites, lipids. Furthermore, discussed major challenges offered a perspective strategy‐based exosomal discovery. We expected in‐depth summary devices–assisted will greatly facilitate biomarkers, thereby realizing highly efficient accurate diagnosis, prediction cancers. Moreover, view significance interesting approach exosomes‐based biopsy, review contribute to translation technology into clinical applications.
Language: Английский
Citations
23