World Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
30(12), P. 1655 - 1662
Published: March 28, 2024
The
gut
microbiota
is
recognized
as
an
endocrine
organ
with
the
capacity
to
influence
distant
organs
and
associated
biological
pathways.
Recent
advancements
underscore
critical
role
of
microbial
homeostasis
in
female
health;
dysbiosis
potentially
leading
diseases
among
women
such
polycystic
ovarian
syndrome,
endometriosis,
breast
cancer,
cervical
cancer
etc.
Despite
this,
there
has
been
limited
discussion
on
underlying
mechanisms.
This
editorial
explores
three
potential
mechanisms
through
which
may
impact
development
women,
namely,
immune
system,
microbiota-estrogen
axis,
metabolite
pathway.
We
focused
approaches
for
treating
by
addressing
imbalances
probiotics,
prebiotics
supplementation,
fecal
transplantation
(FMT).
Future
studies
should
focus
determining
molecular
associations
between
realize
precision
medicine,
FMT
emerging
a
promising
intervention.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7624 - 7624
Published: July 11, 2024
Endometriosis
is
a
hormone-dependent,
chronic
inflammatory
condition
that
affects
5-10%
of
reproductive-aged
women.
It
complex
disorder
characterized
by
the
growth
endometrial-like
tissue
outside
uterus,
which
can
cause
pelvic
pain
and
infertility.
Despite
its
prevalence,
underlying
molecular
mechanisms
this
disease
remain
poorly
understood.
Current
treatment
options
are
limited
focus
mainly
on
suppressing
lesion
activity
rather
than
eliminating
it
entirely.
Although
endometriosis
generally
considered
benign
condition,
substantial
evidence
suggests
increases
risk
developing
specific
subtypes
ovarian
cancer.
The
discovery
cancer
driver
mutations
in
endometriotic
lesions
indicates
may
share
pathways
with
Moreover,
application
single-cell
spatial
genomics,
along
development
organoid
models,
has
started
to
illuminate
etiology.
This
review
aims
summarize
key
genetic
alterations
drive
progression
malignancy.
We
also
significant
recent
advances
understanding
basis
disorder,
as
well
novel
approaches
vitro
models
offer
new
avenues
for
improving
our
pathology
targeted
therapies.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(7), P. 1476 - 1476
Published: July 4, 2024
Endometriosis
is
a
chronic
proinflammatory
pathology
characterized
by
the
growth
of
tissue
similar
to
endometrium
outside
uterus,
affecting
approximately
5
15%
women
worldwide.
Suffering
from
endometriosis
entails
complex
pathophysiological
process,
significantly
impacting
quality
life
and
reproductive
function
affected
women;
therefore,
it
must
be
addressed
in
personalized
comprehensive
manner,
as
its
management
requires
multidisciplinary
approach.
This
article
aims
conduct
literature
review
endometriosis,
not
only
condition
but
also
significant
factor
social,
nutritional,
mental
well-being
those
who
experience
it.
Emphasis
placed
on
importance
understanding
assessing
impact
provide
better
more
approach,
integrating
various
alternatives
strategic
treatments
for
factors
involved
development.
The
aim
complete
overview
pathophysiology
patients,
well
current
treatment
options,
both
pharmacological
alternative,
order
broaden
perspective
improve
care
patients
with
this
disease.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4802 - 4802
Published: April 28, 2024
The
most
common
manifestation
of
endometriosis,
a
condition
characterized
by
the
presence
endometrial-like
tissue
outside
uterus,
is
endometrioma,
cystic
ovarian
lesion.
It
commonly
occurring
associated
with
chronic
pelvic
pain
exacerbated
prior
to
and
during
menstruation,
as
well
infertility.
exact
pathomechanisms
endometrioma
are
still
not
fully
understood.
Emerging
evidence
suggests
pivotal
role
immune
dysregulation
in
pathogenesis
endometriomas,
primarily
influencing
both
local
systemic
inflammatory
processes.
Among
factors
implicated
creation
milieu
alterations
serum
levels
several
cytokines
stand
out,
including
IL-6,
IL-8,
IL-1β,
along
abnormalities
innate
system.
While
numerous
signaling
pathways
have
been
suggested
play
process
linked
only
NF-κB
has
conclusively
demonstrated
be
involved.
Additionally,
increased
oxidative
stress,
resulting
from
contributing
identified
primary
driver
inflammation
condition.
This
article
reviews
current
understanding
dysfunctions
their
implications
for
inflammation.
World Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
30(12), P. 1655 - 1662
Published: March 28, 2024
The
gut
microbiota
is
recognized
as
an
endocrine
organ
with
the
capacity
to
influence
distant
organs
and
associated
biological
pathways.
Recent
advancements
underscore
critical
role
of
microbial
homeostasis
in
female
health;
dysbiosis
potentially
leading
diseases
among
women
such
polycystic
ovarian
syndrome,
endometriosis,
breast
cancer,
cervical
cancer
etc.
Despite
this,
there
has
been
limited
discussion
on
underlying
mechanisms.
This
editorial
explores
three
potential
mechanisms
through
which
may
impact
development
women,
namely,
immune
system,
microbiota-estrogen
axis,
metabolite
pathway.
We
focused
approaches
for
treating
by
addressing
imbalances
probiotics,
prebiotics
supplementation,
fecal
transplantation
(FMT).
Future
studies
should
focus
determining
molecular
associations
between
realize
precision
medicine,
FMT
emerging
a
promising
intervention.
