bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Feb. 14, 2023
Abstract
The
ability
to
flexibly
regulate
emotions
in
a
contextually
appropriate
manner
is
essential
for
individuals
adapt
varying
social
stresses,
and
companion
inflexibility
involves
psychiatric
diseases.
extent
of
this
flexibility
can
be
quantified
by
measuring
neurovascular
coupling
(NVC)-based
hemodynamics
signal
through
functional
brain
imaging.
However,
whether
NVC,
turn,
plays
an
active
role
emotion
regulation
remains
unknown
due
the
absence
exclusive
strategies
bidirectionally
manipulating
NVC.
By
establishing
fifteen
genetic
mouse
lines
suppress
or
enhance
we
demonstrated
that
NVC
allostatic
component
shapes
flexibility.
With
deficits,
same
individual
mice
simultaneously
exhibited
being
overwhelmed
(hyper-response)
suppressing
(hypo-response),
depending
on
different
contexts.
Surprisingly,
knocking
down
vascular
mural
cell
contractile
protein,
local
suppression
within
basal
lateral
amygdala
(BLA),
central
hub,
induces
hyper-response.
Mechanistically,
such
opposite
responses
were
likely
attributed
NVC’s
BLA’s
neural
activity
context-dependent
manner.
Importantly,
BLA
neuron-specific
chemogenetic
antagonization
attenuate
More
importantly,
enhancing
alleviated
emotional
distress
induced
acute
chronic
restraint
stress,
highlighting
potential
as
unique
therapeutic
target
may
avoid
directly
acting
neurons.
These
findings
indicate
bidirectional
modulation
fit
contexts
appropriately,
emphasizing
necessity
proper
maintaining
homeostasis
advanced
functions.
Clinical Gerontologist,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 11
Published: April 14, 2025
This
case
study
evaluates
the
effectiveness
of
online
Acceptance
and
Commitment
Therapy
(ACT)
for
chronic
pain
management
in
an
older
adult,
expanding
on
prior
research
(Campbell,
Podugu,
Morris,
2021)
by
assessing
its
adaptation
telehealth
during
COVID-19.
A
78-year-old
woman
with
completed
a
structured,
eight-session
ACT
program
delivered
via
telehealth.
Quality
life
(QoL),
depression,
physical
activity,
ACT-specific
measures
were
assessed
at
baseline,
post-treatment,
across
multiple
phases.
Online
was
associated
improvements
overall
functioning.
The
participant
demonstrated
excellent
therapy
adherence,
achieved
clinically
significant
gains
improvement
pain.
Positive
outcomes
observed
key
variables.
is
feasible
effective
approach
adults.
Telehealth
adaptations
can
enhance
accessibility
treatment
outcomes,
addressing
barriers
such
as
mobility
limitations
geographical
constraints.
These
findings
align
existing
evidence
supporting
Findings
support
role
adults,
potential
telehealth-based
interventions.
Further
needed
to
evaluate
long-term
generalizability
diverse
populations.
Child Psychiatry & Human Development,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 19, 2025
Abstract
Pediatric
chronic
pain
is
embedded
within
parent-youth
relationships.
Parent
risk
factors
have
been
associated
with
poor
functional
outcomes
in
youth
pain.
Research
delineating
the
role
of
parent
psychological
flexibility
context
pediatric
remains
limited.
The
study
examines
influences
parental
responses
on
youth’s
outcomes.
aims
to
examine
associations
between
and
interference.
127
(66.1%
female)
mixed
etiology
pain,
ranging
age
from
8
17
years
(
M
=
12.24;
SD
1.598),
their
participated
at
an
interdisciplinary
clinic
online
peer
support
groups.
Measures
demographic
characteristics,
interference,
acceptance,
were
collected.
Regression
results
indicated
that
reported
intensity
[
B
3.01,
SE
0.441,
p
<.0005],
−
0.006,
0.003,
0.042]
independently
self-reported
Findings
underscore
how
positively
impacts
related
functioning.
Implications
highlight
need
for
parents’
inclusion
as
targets
change
clinical
interventions
may
further
optimize
treatments
aimed
improving
functioning
by
addressing
flexibility.
Frontiers in Pain Research,
Journal Year:
2025,
Volume and Issue:
6
Published: April 28, 2025
Background
Little
is
known
about
whether
the
recommended,
non-pharmacological
treatments
for
chronic
pain
yield
reductions
in
healthcare
utilization,
social
costs
and
increased
productivity
actual
practice.
Methods
The
primary
aim
of
this
study
(
n
=
232)
was
to
conduct
secondary
analyses
health
economic
outcomes
using
data
from
national
registries
combined
with
clinical
outcome
a
large
center
Sweden
conducting
multidisciplinary
treatment
based
on
cognitive
behavioral
approach.
Specifically,
pain-related
at
post-treatment
one,
two
three
years
after
discharge
were
examined.
In
an
exploratory
fashion,
we
also
investigated
sociodemographic
characteristics,
variables,
psychological
flexibility
predicted
these
long-term
outcomes.
We
examined
as
potential
mediator
Results
Small
moderate
sized
improvements
pain,
interference,
depression
observed
mostly
maintained
both
1-
3-year
follow-up.
A
very
similar
pattern
outcomes,
1-year
follow-up
gains
being
Baseline
but
not
Changes
during
mediated
total
number
care
visits.
Conclusions
present
findings
add
small
body
literature
indicating
that
related
difficulties
following
multidisciplinary,
pain-focused,
CBT
programs
persist
least
treatment,
are
accompanied
by
modest
over
same
interval.
Psychological
seems
be
predominately
associated
management,
it
appears
relevant
Journal of Pain Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 83 - 105
Published: Jan. 1, 2024
Background:
Factors
that
influence
outcomes
of
interdisciplinary
pain
rehabilitation
programs
(IPRP)
are
poorly
known.
It
is
unclear
how
influenced
by
intensity,
psychological
distress,
and
coping
strategies.
Aim:
This
clinical
registry-based
longitudinal
cohort
study
has
three
aims:
1)
to
determine
the
relative
importance
acceptance,
fear-avoidance
for
changes
in
IPRP
at
12-month
follow-up;
2)
investigate
whether
effects
intensity
distress
on
mediated
via
acceptance
fear-avoidance;
3)
sex
a
moderator.
Methods:
uses
Patient-Reported
Outcome
Measures
(PROMs)
from
specialist
units
reporting
data
(2008–
2016)
Swedish
Quality
Registry
Pain
Rehabilitation
(SQRP).
Adult
chronic
patients
(N
=
1991)
answered
PROMs
(background,
pain,
coping,
participation,
health-related
quality
life
(HRQoL)).
Partial
Least
Squares
Structural
Equation
Modelling
(PLS-SEM)
was
used
explore
aims.
Results:
Changes
(β:0.424–
0.553;
all
P<
0.001)
were
strongest
predictor
(changes
control,
interference,
HRQoL)
follow-up.
The
next
baseline
(β:
0.177–
0.233;
−
0.152–
0.186;
0.001).
Baseline
showed
weak
positive
associations.
Their
aspects.
Sex
not
Discussion
Conclusion:
Acceptance
aspects
(baseline
changes)
important
predictors
outcomes.
also
although
lesser
degree.
Some
baseline.
Future
PLS-SEM
analysis
real-world
should
include
more
potential
mediators
(eg,
catastrophizing
facets
flexibility
fear-avoidance)
components
IPRP.
Keywords:
anxiety,
strategies,
depression,
health,
management
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(9), P. 903 - 903
Published: Aug. 26, 2024
This
study
evaluated
Spanish
physiotherapists’
orientations
toward
biopsychosocial
and
biomedical
approaches
in
chronic
pain
management
through
a
cross-sectional
survey
of
447
registered
professionals.
Validated
questionnaires
assessed
knowledge,
attitudes,
beliefs.
Multivariate
analysis
covariance
(MANCOVA)
identified
influential
factors
ordinal
regression
determined
the
frequency
application.
Content
open-ended
responses
explored
barriers
to
implementation.
Over
50%
physiotherapists
favored
model,
influenced
by
interdisciplinary
work
settings,
advanced
specific
training.
Comprehensive
knowledge
significantly
impacted
both
inversely.
The
approach
was
more
prevalent
among
those
with
lower
education
levels
less
particularly
at
beginning
or
over
20
years
into
their
careers.
Despite
theoretical
preference
for
physiotherapists,
practical
application
infrequent,
only
9.8%
always
using
it
40.7%
frequently.
Self-reported
confidence
skills
were
crucial
determinants
implementation
frequency.
Significant
included
inadequate
psychological
(63.6%),
coordination
challenges
(47.6%),
time
constraints
(43.6%),
patient
misconceptions
(34.2%),
systemic
issues.
These
findings
align
international
research,
highlighting
need
bridge
gap
between
clinical
practice.
Addressing
these
targeted
training
reforms
is
improving
globally.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(9), P. 2705 - 2705
Published: May 4, 2024
Background:
Rejection,
injustice,
and
exclusion
from
meaningful
interpersonal
relationships
are
often
extremely
painful
stress-generating
experiences.
This
study
aimed
to
define
the
role
of
explicit
implicit
self-esteem
in
pain
perception
as
a
component
physiological–psychological
system
that
regulates
body’s
response
stress
associated
with
threat
social
rejection.
Methods:
In
total,
360
individuals
participated
this
study.
The
measurement
cortisol
saliva,
assessment
thresholds
using
thermal
stimuli,
IAT
assess
self-esteem,
questionnaire
on
global
were
used.
included
three
measurements:
baseline
15
45
min
after
application
laboratory
socially
threatening
stimulus
(the
Trier
Social
Stress
Test).
Results:
People
experiencing
chronic
(CSP)
more
likely
have
fragile
higher
thresholds,
tend
experience
reduced
tolerance
situations
acute
than
people
without
CSP
experience.
introduction
threat,
an
increase
was
observed
along
longer-lasting
levels.
Conclusions:
Fragile
feelings
exclusion,
rejection,
may
prolong
reactions
produce
hypoalgesic
effect.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 9, 2024
Abstract
Background
In
the
nursing
workforce,
operating
room(OR)
nurses
are
at
high
risk
for
psychological
issues
due
to
unique
challenges
of
their
work
environment.
Psychological
flexibility(PF),
as
a
protective
element
mental
health,
is
important
promoting
acceptance
and
adjustment
nurses.
This
study
used
latent
profile
analysis(LPA)
identify
profiles
PF
among
OR
further
explored
associated
influencing
factors.
Methods
A
cross-sectional
was
conducted
on
403
room
in
Southwest
China
from
November
2023
April
2024
(effective
rate
91.18%).
measured
by
Simplified
Multidimensional
Flexibility
Inventory(MPFI-24),
social
support
Social
Support
Rating
Scale(SSRS),
coping
style
Trait
Coping
Style
Questionnaire(TCSQ).
We
LPA
Mplus.8.3
PF.
Multinomial
logistic
regression
analysis
analyse
factors
relevant
different
profiles.
Results
The
can
be
identified
into
4
groups:
group(14.1%),
medium
group-high
engagement
type(33.7%),
lower-middle
group(32.6%),
low
goup(19.6%).
Gender,
birthplace,
whether
you
like
nursing,
scores,
styles
scores
predictors
Conclusions
Our
findings
nurses,
showing
heterogeneity
OR.
predict
may
provide
reference
development
targeted
interventional
strategies
improve
Education Modern Discourses,
Journal Year:
2024,
Volume and Issue:
7
Published: Dec. 30, 2024
The
article
is
aimed
at
the
exploring
Israeli
experience
of
rehabilitation
war
veterans
and
possibilities
its
extrapolation
into
training
system
military
psychologists
in
Ukraine.
study
a
component
scientific
research
“Information
analytical
support
psychological
science
post-war
periods
Ukraine”
(2024-2025),
which
being
implemented
V.
Sukhomlynskyi
State
Scientific
Educational
Library
authors
use
method,
consists
broad
transfer
evidence
from
one
part
phenomenon
to
another.
An
analysis
works
was
conducted
reveal
topic
study;
confirmation
relevance
for
approach
people
who
survived
hostilities
returned
civilian
life
after
receiving
injuries,
disabilities,
or
trauma
analyzed.
It
stated
that
occupies
leading
place
information
psychologists,
context
development
problem