Neurovascular coupling actively regulates context-dependent emotional adjustment DOI Open Access
Jiayu Ruan,

Xinghua Quan,

Huiqi Xie

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 14, 2023

Abstract The ability to flexibly regulate emotions in a contextually appropriate manner is essential for individuals adapt varying social stresses, and companion inflexibility involves psychiatric diseases. extent of this flexibility can be quantified by measuring neurovascular coupling (NVC)-based hemodynamics signal through functional brain imaging. However, whether NVC, turn, plays an active role emotion regulation remains unknown due the absence exclusive strategies bidirectionally manipulating NVC. By establishing fifteen genetic mouse lines suppress or enhance we demonstrated that NVC allostatic component shapes flexibility. With deficits, same individual mice simultaneously exhibited being overwhelmed (hyper-response) suppressing (hypo-response), depending on different contexts. Surprisingly, knocking down vascular mural cell contractile protein, local suppression within basal lateral amygdala (BLA), central hub, induces hyper-response. Mechanistically, such opposite responses were likely attributed NVC’s BLA’s neural activity context-dependent manner. Importantly, BLA neuron-specific chemogenetic antagonization attenuate More importantly, enhancing alleviated emotional distress induced acute chronic restraint stress, highlighting potential as unique therapeutic target may avoid directly acting neurons. These findings indicate bidirectional modulation fit contexts appropriately, emphasizing necessity proper maintaining homeostasis advanced functions.

Language: Английский

Online Acceptance and Commitment Therapy for Chronic Pain in an Older Adult: A Telehealth Approach Amid COVID-19 DOI Creative Commons
Rebecca Campbell,

Sai Durga Vara Prasada Rao Podugu,

Mary Morris

et al.

Clinical Gerontologist, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 14, 2025

This case study evaluates the effectiveness of online Acceptance and Commitment Therapy (ACT) for chronic pain management in an older adult, expanding on prior research (Campbell, Podugu, Morris, 2021) by assessing its adaptation telehealth during COVID-19. A 78-year-old woman with completed a structured, eight-session ACT program delivered via telehealth. Quality life (QoL), depression, physical activity, ACT-specific measures were assessed at baseline, post-treatment, across multiple phases. Online was associated improvements overall functioning. The participant demonstrated excellent therapy adherence, achieved clinically significant gains improvement pain. Positive outcomes observed key variables. is feasible effective approach adults. Telehealth adaptations can enhance accessibility treatment outcomes, addressing barriers such as mobility limitations geographical constraints. These findings align existing evidence supporting Findings support role adults, potential telehealth-based interventions. Further needed to evaluate long-term generalizability diverse populations.

Language: Английский

Citations

0

Parent Psychological Flexibility in Pediatric Chronic Pain DOI Creative Commons
Joan Hanania, Jessica B. Edwards George, Christie J. Rizzo

et al.

Child Psychiatry & Human Development, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract Pediatric chronic pain is embedded within parent-youth relationships. Parent risk factors have been associated with poor functional outcomes in youth pain. Research delineating the role of parent psychological flexibility context pediatric remains limited. The study examines influences parental responses on youth’s outcomes. aims to examine associations between and interference. 127 (66.1% female) mixed etiology pain, ranging age from 8 17 years ( M = 12.24; SD 1.598), their participated at an interdisciplinary clinic online peer support groups. Measures demographic characteristics, interference, acceptance, were collected. Regression results indicated that reported intensity [ B 3.01, SE 0.441, p <.0005], − 0.006, 0.003, 0.042] independently self-reported Findings underscore how positively impacts related functioning. Implications highlight need for parents’ inclusion as targets change clinical interventions may further optimize treatments aimed improving functioning by addressing flexibility.

Language: Английский

Citations

0

Long-term pain and health economic outcomes in adults receiving multidisciplinary CBT for chronic pain: the role of psychological inflexibility DOI Creative Commons
Sophia Åkerblom, Lance M. McCracken, Marcelo Rivano Fischer

et al.

Frontiers in Pain Research, Journal Year: 2025, Volume and Issue: 6

Published: April 28, 2025

Background Little is known about whether the recommended, non-pharmacological treatments for chronic pain yield reductions in healthcare utilization, social costs and increased productivity actual practice. Methods The primary aim of this study ( n = 232) was to conduct secondary analyses health economic outcomes using data from national registries combined with clinical outcome a large center Sweden conducting multidisciplinary treatment based on cognitive behavioral approach. Specifically, pain-related at post-treatment one, two three years after discharge were examined. In an exploratory fashion, we also investigated sociodemographic characteristics, variables, psychological flexibility predicted these long-term outcomes. We examined as potential mediator Results Small moderate sized improvements pain, interference, depression observed mostly maintained both 1- 3-year follow-up. A very similar pattern outcomes, 1-year follow-up gains being Baseline but not Changes during mediated total number care visits. Conclusions present findings add small body literature indicating that related difficulties following multidisciplinary, pain-focused, CBT programs persist least treatment, are accompanied by modest over same interval. Psychological seems be predominately associated management, it appears relevant

Language: Английский

Citations

0

Acceptance and Fear-Avoidance Mediate Outcomes of Interdisciplinary Pain Rehabilitation Programs at 12-Month Follow-Up: A Clinical Registry-Based Longitudinal Cohort Study from the Swedish Quality Registry for Pain Rehabilitation (SQRP) DOI Creative Commons
Björn Gerdle, Elena Dragioti, Marcelo Rivano Fischer

et al.

Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 83 - 105

Published: Jan. 1, 2024

Background: Factors that influence outcomes of interdisciplinary pain rehabilitation programs (IPRP) are poorly known. It is unclear how influenced by intensity, psychological distress, and coping strategies. Aim: This clinical registry-based longitudinal cohort study has three aims: 1) to determine the relative importance acceptance, fear-avoidance for changes in IPRP at 12-month follow-up; 2) investigate whether effects intensity distress on mediated via acceptance fear-avoidance; 3) sex a moderator. Methods: uses Patient-Reported Outcome Measures (PROMs) from specialist units reporting data (2008– 2016) Swedish Quality Registry Pain Rehabilitation (SQRP). Adult chronic patients (N = 1991) answered PROMs (background, pain, coping, participation, health-related quality life (HRQoL)). Partial Least Squares Structural Equation Modelling (PLS-SEM) was used explore aims. Results: Changes (β:0.424– 0.553; all P< 0.001) were strongest predictor (changes control, interference, HRQoL) follow-up. The next baseline (β: 0.177– 0.233; − 0.152– 0.186; 0.001). Baseline showed weak positive associations. Their aspects. Sex not Discussion Conclusion: Acceptance aspects (baseline changes) important predictors outcomes. also although lesser degree. Some baseline. Future PLS-SEM analysis real-world should include more potential mediators (eg, catastrophizing facets flexibility fear-avoidance) components IPRP. Keywords: anxiety, strategies, depression, health, management

Language: Английский

Citations

2

Chronic Pain Management Approaches among Spanish Physiotherapists: Influences, Practices, Barriers, and Challenges DOI Open Access
Ángeles Díaz-Fernández, Irene Cortés‐Pérez, Esteban Obrero‐Gaitán

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(9), P. 903 - 903

Published: Aug. 26, 2024

This study evaluated Spanish physiotherapists’ orientations toward biopsychosocial and biomedical approaches in chronic pain management through a cross-sectional survey of 447 registered professionals. Validated questionnaires assessed knowledge, attitudes, beliefs. Multivariate analysis covariance (MANCOVA) identified influential factors ordinal regression determined the frequency application. Content open-ended responses explored barriers to implementation. Over 50% physiotherapists favored model, influenced by interdisciplinary work settings, advanced specific training. Comprehensive knowledge significantly impacted both inversely. The approach was more prevalent among those with lower education levels less particularly at beginning or over 20 years into their careers. Despite theoretical preference for physiotherapists, practical application infrequent, only 9.8% always using it 40.7% frequently. Self-reported confidence skills were crucial determinants implementation frequency. Significant included inadequate psychological (63.6%), coordination challenges (47.6%), time constraints (43.6%), patient misconceptions (34.2%), systemic issues. These findings align international research, highlighting need bridge gap between clinical practice. Addressing these targeted training reforms is improving globally.

Language: Английский

Citations

2

Guided internet‐based acceptance and commitment therapy for provoked vestibulodynia: A randomized controlled trial DOI Creative Commons
Monica Buhrman,

Hanna Hällström,

Annika Fridén

et al.

European Journal of Pain, Journal Year: 2024, Volume and Issue: 28(7), P. 1185 - 1201

Published: March 1, 2024

Provoked vestibulodynia (PVD) causes suffering in many women's lives due to its impact on relationships, sexual functioning and other key domains.

Language: Английский

Citations

1

Pain of Threatened Self: Explicit and Implicit Self-Esteem, Cortisol Responses to a Social Threat and Pain Perception DOI Open Access
Ewa Wojtyna, Magdalena Hyla,

Aleksandra Hachuła

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(9), P. 2705 - 2705

Published: May 4, 2024

Background: Rejection, injustice, and exclusion from meaningful interpersonal relationships are often extremely painful stress-generating experiences. This study aimed to define the role of explicit implicit self-esteem in pain perception as a component physiological–psychological system that regulates body’s response stress associated with threat social rejection. Methods: In total, 360 individuals participated this study. The measurement cortisol saliva, assessment thresholds using thermal stimuli, IAT assess self-esteem, questionnaire on global were used. included three measurements: baseline 15 45 min after application laboratory socially threatening stimulus (the Trier Social Stress Test). Results: People experiencing chronic (CSP) more likely have fragile higher thresholds, tend experience reduced tolerance situations acute than people without CSP experience. introduction threat, an increase was observed along longer-lasting levels. Conclusions: Fragile feelings exclusion, rejection, may prolong reactions produce hypoalgesic effect.

Language: Английский

Citations

0

Profiles of psychological flexibility and influencing factors among operating room nurses: A latent profile analysis DOI Creative Commons

Xiangzhi Sun,

Yanmei Miao, Jing Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 9, 2024

Abstract Background In the nursing workforce, operating room(OR) nurses are at high risk for psychological issues due to unique challenges of their work environment. Psychological flexibility(PF), as a protective element mental health, is important promoting acceptance and adjustment nurses. This study used latent profile analysis(LPA) identify profiles PF among OR further explored associated influencing factors. Methods A cross-sectional was conducted on 403 room in Southwest China from November 2023 April 2024 (effective rate 91.18%). measured by Simplified Multidimensional Flexibility Inventory(MPFI-24), social support Social Support Rating Scale(SSRS), coping style Trait Coping Style Questionnaire(TCSQ). We LPA Mplus.8.3 PF. Multinomial logistic regression analysis analyse factors relevant different profiles. Results The can be identified into 4 groups: group(14.1%), medium group-high engagement type(33.7%), lower-middle group(32.6%), low goup(19.6%). Gender, birthplace, whether you like nursing, scores, styles scores predictors Conclusions Our findings nurses, showing heterogeneity OR. predict may provide reference development targeted interventional strategies improve

Language: Английский

Citations

0

Catastrophizing in Fibromyalgia DOI
Carmen Écija, Patricia Catalá, Lorena Gutiérrez

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0

ISRAELI EXPERIENCE IN THE REHABILITATION OF MILITARY VETERANS FOR THE TRAINING SYSTEM OF MILITARY PSYCHOLOGISTS IN UKRAINE DOI Creative Commons

Olha Luchaninova,

Yaroslav Pylypchuk

Education Modern Discourses, Journal Year: 2024, Volume and Issue: 7

Published: Dec. 30, 2024

The article is aimed at the exploring Israeli experience of rehabilitation war veterans and possibilities its extrapolation into training system military psychologists in Ukraine. study a component scientific research “Information analytical support psychological science post-war periods Ukraine” (2024-2025), which being implemented V. Sukhomlynskyi State Scientific Educational Library authors use method, consists broad transfer evidence from one part phenomenon to another. An analysis works was conducted reveal topic study; confirmation relevance for approach people who survived hostilities returned civilian life after receiving injuries, disabilities, or trauma analyzed. It stated that occupies leading place information psychologists, context development problem

Language: Английский

Citations

0