Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Physiological Reviews,
Journal Year:
2023,
Volume and Issue:
103(4), P. 2679 - 2757
Published: June 29, 2023
Mechanisms
underlying
mechanical
overload-induced
skeletal
muscle
hypertrophy
have
been
extensively
researched
since
the
landmark
report
by
Morpurgo
(1897)
of
“work-induced
hypertrophy”
in
dogs
that
were
treadmill
trained.
Much
preclinical
rodent
and
human
resistance
training
research
to
date
supports
involved
mechanisms
include
enhanced
mammalian/mechanistic
target
rapamycin
complex
1
(mTORC1)
signaling,
an
expansion
translational
capacity
through
ribosome
biogenesis,
increased
satellite
cell
abundance
myonuclear
accretion,
postexercise
elevations
protein
synthesis
rates.
However,
several
lines
past
emerging
evidence
suggest
additional
feed
into
or
are
independent
these
processes
also
involved.
This
review
first
provides
a
historical
account
how
mechanistic
has
progressed.
A
comprehensive
list
associated
with
is
then
outlined,
areas
disagreement
involving
presented.
Finally,
future
directions
many
discussed
proposed.
Language: Английский
Ovarian aging: energy metabolism of oocytes
Shenglan Bao,
No information about this author
Tailang Yin,
No information about this author
Su Liu
No information about this author
et al.
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 31, 2024
Abstract
In
women
who
are
getting
older,
the
quantity
and
quality
of
their
follicles
or
oocytes
decline.
This
is
characterized
by
decreased
ovarian
reserve
function
(DOR),
fewer
remaining
oocytes,
lower
oocytes.
As
more
choose
to
delay
childbirth,
decline
in
fertility
associated
with
age
has
become
a
significant
concern
for
modern
women.
The
oocyte
key
indicator
aging.
Many
studies
suggest
that
age-related
changes
energy
metabolism
may
impact
quality.
Changes
affect
adenosine
5'-triphosphate
(ATP)
production,
but
how
related
products
proteins
influence
remains
largely
unknown.
review
focuses
on
aging
its
potential
quality,
as
well
therapeutic
strategies
partially
metabolism.
research
aims
enhance
our
understanding
metabolism,
identification
biomarkers
treatment
methods.
Language: Английский
miRNA‐1 regulation is necessary for mechanical overload‐induced muscle hypertrophy in male mice
Shengyi Fei,
No information about this author
Blake D. Rule,
No information about this author
Joshua S. Godwin
No information about this author
et al.
Physiological Reports,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Jan. 1, 2025
Abstract
MicroRNAs
(miRNAs)
are
small,
noncoding
RNAs
that
play
a
critical
role
in
regulating
gene
expression
post‐transcriptionally.
They
involved
various
developmental
and
physiological
processes,
their
dysregulation
is
linked
to
diseases.
Skeletal
muscle‐specific
miRNAs,
including
miR‐1,
crucial
the
development
maintenance
of
skeletal
muscle.
It
has
been
demonstrated
miR‐1
decreases
by
approximately
50%
response
hypertrophic
stimuli,
suggesting
its
potential
involvement
muscle
hypertrophy.
In
our
study,
we
hypothesize
reduction
levels
necessary
for
growth
due
interaction
essential
pro‐growth
genes.
Promoting
smaller
levels,
observed
blunted
mice
undergoing
murine
model
addition,
results
suggest
inhibits
Itm2a
,
membrane‐related
protein,
as
miR‐1‐related
candidate
While
exact
mechanism
hypertrophy
not
identified,
miR‐1‐regulated
membrane
proteins
important
Language: Английский
The roles of miRNAs in adult skeletal muscle satellite cells
Free Radical Biology and Medicine,
Journal Year:
2023,
Volume and Issue:
209, P. 228 - 238
Published: Oct. 24, 2023
Language: Английский
miR-100-5p Regulates Skeletal Muscle Myogenesis through the Trib2/mTOR/S6K Signaling Pathway
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(10), P. 8906 - 8906
Published: May 17, 2023
MicroRNAs
(miRNAs)
are
endogenous
small
non-coding
RNAs
that
play
crucial
regulatory
roles
in
many
biological
processes,
including
the
growth
and
development
of
skeletal
muscle.
miRNA-100-5p
is
often
associated
with
tumor
cell
proliferation
migration.
This
study
aimed
to
uncover
mechanism
myogenesis.
In
our
study,
we
found
expression
level
was
significantly
higher
muscle
tissue
than
other
tissues
pigs.
Functionally,
this
shows
miR-100-5p
overexpression
promotes
inhibits
differentiation
C2C12
myoblasts,
whereas
inhibition
results
opposite
effects.
Bioinformatic
analysis
predicted
Trib2
has
potential
binding
sites
for
at
3′UTR
region.
A
dual-luciferase
assay,
qRT-qPCR,
Western
blot
confirmed
a
target
gene
miR-100-5p.
We
further
explored
function
myogenesis
knockdown
markedly
facilitated
but
suppressed
which
contrary
effects
addition,
co-transfection
experiments
demonstrated
could
attenuate
on
myoblasts
differentiation.
terms
molecular
mechanism,
by
inactivating
mTOR/S6K
signaling
pathway.
Taken
together,
indicate
regulates
through
Trib2/mTOR/S6K
Language: Английский
Exploring frontiers in musculoskeletal biology and bioengineering
AJP Cell Physiology,
Journal Year:
2024,
Volume and Issue:
326(3), P. C659 - C660
Published: Jan. 22, 2024
Language: Английский
Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
AJP Cell Physiology,
Journal Year:
2023,
Volume and Issue:
325(5), P. C1276 - C1293
Published: Sept. 25, 2023
Disuse-induced
muscle
atrophy
is
a
common
clinical
problem
observed
mainly
in
older
adults,
intensive
care
units
patients,
or
astronauts.
Previous
studies
presented
biological
sex
divergence
progression
of
disuse-induced
along
with
differential
changes
molecular
mechanisms
possibly
underlying
atrophy.
The
aim
this
study
was
to
perform
transcriptomic
profiling
male
and
female
mice
during
the
onset
unloading
Male
underwent
hindlimb
(HU)
for
24,
48,
72,
168
h
(
Language: Английский