Advances in clinical chemistry, Journal Year: 2010, Volume and Issue: unknown, P. 25 - 52
Published: Jan. 1, 2010
Language: Английский
Critical Reviews in Food Science and Nutrition, Journal Year: 2015, Volume and Issue: 56(11), P. 1868 - 1879
Published: Feb. 12, 2015
The present review is based mainly on papers published between 2000 and 2011 gives information about the properties of carotenoid lycopene in chemical biological systems its possible role preventing cardiovascular diseases (CVD). main aim this report to highlight as an antioxidant, also reported are bioactive that may influence development foam cells protection against endothelial cell damage. paper will examine recent observations improve blood flow reduce inflammatory responses. Lycopene possesses antioxidant vitro, some epidemiological studies have protective effects progression CVD. oxidation human low density lipoproteins (LDL) a fundamental mechanism initiation atherosclerosis. A beneficial prevention CVD suggested but data still controversial. believed be most potent vitro. Tissue culture experiments animal support potential cardioprotective for other carotenoids blood. Most showed individuals who antioxidant-deficient like elderly patients, or humans exposed higher levels oxidative stress smokers, diabetics, hemodialysis patients acute myocardial infarction patients. By defining right population combining potentials with vitamins plant compounds, can clarified future studies.
Language: Английский
Citations
209
Pharmacological Reviews, Journal Year: 2019, Volume and Issue: 71(4), P. 596 - 670
Published: Sept. 25, 2019
Foam cell formation and further accumulation in the subendothelial space of vascular wall is a hallmark atherosclerotic lesions. Targeting foam lesions can be promising approach to treat prevent atherosclerosis. The cells determined by balanced effects three major interrelated biologic processes, including lipid uptake, cholesterol esterification, efflux. Natural products are source for new lead structures. Multiple natural pharmaceutical agents inhibit thus exhibit antiatherosclerotic capacity suppressing and/or promoting ester hydrolysis This review summarizes recent findings on these processes with demonstrated potential target such processes. Discussed also future directions studying mechanisms development cell-targeted therapeutic strategies.
Language: Английский
Citations
174
Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9
Published: May 23, 2018
Lycopene is a lipophilic, unsaturated carotenoid, found in red-colored fruits and vegetables, including tomatoes, watermelon, papaya, red grapefruits, guava. The present work provides an up to date overview of mechanisms linking lycopene the human diet vascular changes, considering epidemiological data, clinical studies, experimental data. may improve function contributes primary secondary prevention cardiovascular disorders. main activity profile includes antiatherosclerotic, antioxidant, anti-inflammatory, antihypertensive, antiplatelet, anti-apoptotic, protective endothelial effects, ability metabolic profile, reduce arterial stiffness. In this context, has been shown numerous studies exert favorable effect patients with subclinical atherosclerosis, syndrome, hypertension, peripheral disease, stroke several other disorders, although obtained results are sometimes inconsistent, which warrants further focusing on its bioactivity.
Language: Английский
Citations
171
Annals of Nutrition and Metabolism, Journal Year: 2012, Volume and Issue: 61(2), P. 126 - 134
Published: Jan. 1, 2012
<b><i>Background/Aims:</i></b> Increased ingestion of tomato, containing lycopene, has been associated with a decreased risk for atherosclerosis, although the exact molecular mechanism is still unknown. Here we review available evidence direct regulation tomato lycopene on cholesterol metabolism using results from experimental and human studies. <b><i>Results:</i></b> In macrophages dose dependently reduced intracellular total cholesterol. Such an effect was decrease in synthesis through reduction 3-hydroxy-3-methylglutaryl coenzyme A reductase activity expression, modulation low- density lipoprotein (LDL) receptor acyl-coenzyme A:cholesterol acyltransferase activity. An increase efflux enhancement ABCA1 caveolin-1 expression also observed. animal models products plasma cholesterol, LDL increased high-density agreement results, most intervention trials analyzed show that dietary supplementation and/or time administration. <b><i>Conclusions:</i></b> Although seem to possess hypocholesterolemic properties, more studies are needed better understand mechanisms involved. There need well-designed clarify role as agent.
Language: Английский
Citations
151
Proceedings of The Nutrition Society, Journal Year: 2016, Volume and Issue: 76(2), P. 122 - 129
Published: Sept. 9, 2016
Epidemiological evidence indicates that high consumption of tomatoes and tomato-based products reduces the risk chronic diseases such as CVD cancer. Such potential benefits are often ascribed to concentrations lycopene present in tomato products. Mainly from results vitro studies, biological mechanisms by which carotenoids could protect against heart disease cancer have been suggested. These include cholesterol reduction, inhibition oxidation processes, modulation inflammatory markers, enhanced intercellular communication, tumourigenesis induction apoptosis, metabolism retinoids antiangiogenic effects. However, with regard CVD, intervention studies gave mixed results. Over fifty human trials supplements or conducted date, majority being underpowered. Many showed some beneficial effects but mostly on non-established cardiovascular markers lipid peroxidation, DNA oxidative damage, platelet activation markers. Only a few improvement profiles, C reactive protein blood pressure. recent findings indicate exert protection lowering HDL-associated inflammation, well modulating HDL functionality towards an antiatherogenic phenotype. Furthermore, modulate T lymphocyte activity, would also inhibit atherogenic processes confer protection. suggest deserves further consideration early marker for risk, modifiable dietary factors lycopene.
Language: Английский
Citations
115
Pharmacological Research, Journal Year: 2020, Volume and Issue: 159, P. 104966 - 104966
Published: June 12, 2020
Language: Английский
Citations
102
Experimental Biology and Medicine, Journal Year: 2011, Volume and Issue: 236(2), P. 169 - 176
Published: Feb. 1, 2011
Recent evidence indicates that hydrogen sulfide (H 2 S) exerts an antiatherogenic effect, but the mechanism is unclear. Formation of macrophage-derived foam cells a crucial event in development atherosclerosis. Thus, we explore effect H S on formation cells. Incubation monocyte-derived macrophages with oxidized LDL (oxLDL) alone caused significant increases both intracellular lipids revealed by Oil-red O staining and total cholesterol (TC) esterified (EC) concentrations assessed high-performance liquid chromatography. Sodium hydrosulfide (NaHS, donor) remarkably abrogated oxLDL-induced lipid accumulation, attenuated TC EC EC/TC ratio, whereas dl-propargylglycine (PPG) (a S-generating enzyme cystathionine gamma lyase inhibitor) exacerbated accumulation augmented ratio. 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI)-oxLDL led to lipoprotein binding uptake macrophages, which was blunted NaHS, enhanced PPG. Furthermore, OxLDL markedly induced CD36, scavenger receptor A (SR-A) acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) expressions suppressed NaHS (50–200 μmol/L). Finally, down-regulations as well CD36 ACAT-1 were glibenclamide, K ATP channel blocker, facilitated PD98059, extracellular signal-regulated kinases 1 (ERK1/2) inhibitor. These results suggested inhibits cell down-regulating SR-A ACAT1 via /ERK1/2 pathway human macrophages.
Language: Английский
Citations
106
PLoS ONE, Journal Year: 2011, Volume and Issue: 6(5), P. e19652 - e19652
Published: May 19, 2011
Increasing evidence suggests that lycopene, the major carotenoid present in tomato, may be preventive against smoke-induced cell damage. However, mechanisms of such a prevention are still unclear. The aim this study was to investigate role lycopene on production pro-inflammatory cytokine IL-8 induced by cigarette smoke and possible implicated. Therefore, human THP-1 macrophages were exposed extract (CSE), alone following 6-h pre-treatment with (0.5–2 µM). CSE enhanced time- dose-dependent manner. Lycopene resulted significant inhibition CSE-induced expression at both mRNA protein levels. NF-kB controlled transcription CSE, since PDTC prevented production. suppressed DNA binding, NF-kB/p65 nuclear translocation phosphorylation IKKα IkBα. Such an accompanied decrease ROS NOX-4 expression. further inhibited redox-sensitive ERK1/2, JNK p38 MAPKs. Moreover, increased PPARγ levels which, turn, PTEN decreased pAKT CSE-exposed cells. effects abolished inhibitor GW9662. Taken together, our data indicate through mechanism involving inactivation NF-kB. redox signalling activation signalling. ability inhibiting production, translocation, increasing also found isolated rat alveolar CSE. These findings provide novel new molecular which regulates smoke-driven inflammation macrophages.
Language: Английский
Citations
105
The Journal of Nutritional Biochemistry, Journal Year: 2010, Volume and Issue: 22(3), P. 259 - 268
Published: June 23, 2010
Language: Английский
Citations
105
Archives of Biochemistry and Biophysics, Journal Year: 2010, Volume and Issue: 504(1), P. 26 - 33
Published: July 4, 2010
Language: Английский
Citations
100