Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

Antioxidants, Journal Year: 2020, Volume and Issue: 9(8), P. 706 - 706

Published: Aug. 4, 2020

Lycopene, belonging to the carotenoids, is a tetraterpene compound abundantly found in tomato and tomato-based products. It fundamentally recognized as potent antioxidant non-pro-vitamin A carotenoid. Lycopene has been be efficient ameliorating cancer insurgences, diabetes mellitus, cardiac complications, oxidative stress-mediated malfunctions, inflammatory events, skin bone diseases, hepatic, neural reproductive disorders. This review summarizes information regarding its sources uses amongst different societies, biochemistry aspects, potential utilization of lycopene possible mechanisms involved alleviating abovementioned Furthermore, future directions with use this nutraceutical against lifestyle-related disorders are emphasized. Its protective effects recommended doses toxic agents toxicity safety also discussed.

Language: Английский

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Nutrition and Cardiovascular Health

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(12), P. 3988 - 3988

Published: Dec. 11, 2018

Cardiovascular disease (CVD) is the leading cause of death in Western countries, representing almost 30% all deaths worldwide. Evidence shows effectiveness healthy dietary patterns and lifestyles for prevention CVD. Furthermore, rising incidence CVD over last 25 years has become a public health priority, especially (or cardiovascular events) through lifestyle interventions. Current scientific evidence that compared to healthier patterns, such as 'Mediterranean diet' (MeDiet), leads an excessive production proinflammatory cytokines associated with reduced synthesis anti-inflammatory cytokines. In fact, intervention allows better combination multiple foods nutrients. Therefore, pattern greater magnitude beneficial effects than potential single nutrient supplementation. This review aims identify targets (food foods, or individual nutrients) preventing quantifies observed. On other hand, we analyze possible mechanisms implicated this cardioprotective effect.

Language: Английский

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Lycopene: Food Sources, Biological Activities, and Human Health Benefits

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

As an antioxidant, lycopene has acquired importance as it prevents autoxidation of fats and related products. Tomatoes are important agricultural product that is a great source lycopene. It contains many vitamins minerals, fiber, carbohydrates associated with various positive effects on health. The antioxidant potential tomatoes substantially explained compounds. Diet major risk factor for heart diseases which shown the most cause death in world. been observed taken diet stages atherosclerosis. serum lipid levels, endothelial dysfunction, inflammation, blood pressure, antioxidative mainly affected by These natural antioxidants, can also enhance nutritional value foods, may lead to new ways if used food preservation. In this review study, cardiovascular protection mechanism discussed.

Language: Английский

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Metabolic and Vascular Effect of the Mediterranean Diet

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(19), P. 4716 - 4716

Published: Sept. 23, 2019

Several studies indicated how dietary patterns that were obtained from nutritional cluster analysis can predict disease risk or mortality. Low-grade chronic inflammation represents a background pathogenetic mechanism linking metabolic factors to increased of degenerative diseases. A Mediterranean diet (MeDi) style has been reported as associated with lower degree biomarkers and protective role on cardiovascular cerebrovascular events. There is heterogeneity in defining the MedDiet, it can, owing its complexity, be considered an exposome thousands nutrients phytochemicals. Recently, novel positive association between baseline plasma ceramide concentrations events adherence Diet-style may influence potential negative relationship elevated diseases (CVD). randomized controlled trials (RCTs) showed effects MeDi several factors, such body mass index, waist circumference, blood lipids, pressure, inflammatory markers adhesion molecules, diabetes these advantages are maintained comparison low-fat diet. Some effect Diet heart failure incidence, whereas some recent studies, PREDIMED study, incidence major was among those assigned supplemented extra-virgin olive oil nuts than reduced-fat New needed better understand molecular mechanisms, whereby MedDiet exercise effects. Here, we present advances understanding basis effects, mainly focusing diseases, but also discussing other related We review composition assessment well latest genomic, epigenomic (DNA methylation, histone modifications, microRNAs, emerging regulators), transcriptomic (selected genes whole transcriptome), metabolomic metagenomic aspects (as for most typical food components). clinical this underlying biochemical Our purpose main features particular benefits human health, underling anti-inflammatory, anti-oxidant anti-atherosclerotic which new knowledge about epigenetic gut-microbiota recently added.

Language: Английский

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Lycopene – a bioactive carotenoid offering multiple health benefits: a review

International Journal of Food Science & Technology, Journal Year: 2019, Volume and Issue: 55(1), P. 11 - 32

Published: July 24, 2019

Summary Lycopene is a natural red tomato pigment whose presence in the diet beneficial to human health. It believed modify course of chronic conditions, including neoplastic diseases. Clinical research results confirm its protective effects on cardiovascular system. lowers risk myocardial infarction, reduces blood pressure and prevents LDL cholesterol oxidation. High lycopene concentrations are also associated with lower risks developing prostate, lung, uterine breast cancer. does not only inhibit proliferation cells, but it induces their apoptosis metastasis. The health attributed this compound mostly derived from antioxidant properties. strong singlet oxygen quencher, thwarts lipid Experimental clinical studies have confirmed lycopene's positive skeletal system neurodegenerative diseases, Alzheimer's Parkinson's.

Language: Английский

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Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products

Pharmacological Reviews, Journal Year: 2019, Volume and Issue: 71(4), P. 596 - 670

Published: Sept. 25, 2019

Foam cell formation and further accumulation in the subendothelial space of vascular wall is a hallmark atherosclerotic lesions. Targeting foam lesions can be promising approach to treat prevent atherosclerosis. The cells determined by balanced effects three major interrelated biologic processes, including lipid uptake, cholesterol esterification, efflux. Natural products are source for new lead structures. Multiple natural pharmaceutical agents inhibit thus exhibit antiatherosclerotic capacity suppressing and/or promoting ester hydrolysis This review summarizes recent findings on these processes with demonstrated potential target such processes. Discussed also future directions studying mechanisms development cell-targeted therapeutic strategies.

Language: Английский

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Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation

Biology, Journal Year: 2022, Volume and Issue: 11(2), P. 239 - 239

Published: Feb. 4, 2022

This review outlines the health benefits associated with regular consumption of tomatoes and tomato products. The first section provides a detailed account horticultural techniques that can impact quality fruit its nutritional properties, including water availability, light intensity, temperature, growing media. next information on components are likely to contribute effects. then details some consumption, anticancer cardiovascular neurodegenerative diseases skin health. also discusses have gut microbiome benefits, reducing risk inflammatory bowel diseases. Other eating discussed in relation effects diabetes, immune response, exercise recovery, fertility. Finally, this addresses negative occur as result overconsumption products lycopene supplements.

Language: Английский

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The current use and evolving landscape of nutraceuticals

Pharmacological Research, Journal Year: 2021, Volume and Issue: 175, P. 106001 - 106001

Published: Nov. 24, 2021

Language: Английский

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Potential inhibitory effect of lycopene on prostate cancer

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 129, P. 110459 - 110459

Published: June 30, 2020

Studying prostate cancer is important due to its high annual incidences and mortality rates in the world. Although are reduced using new therapy, complicated routes side effects of these current drugs require a daily available treatment for prevention. Lycopene natural, prominent, effective product which has value diet. The anti-cancer effect, non-toxicity, safety preventive or therapeutic roles lycopene have been investigated several studies. In review, we collected information about anti-cancer, anti-progressive apoptotic on cancer. This article summary most original review articles anticancer that systematically categorized presents molecular structure, different sources, biological functions, in-vivo in-vitro variety cancerous normal cells. clinical studies provide clear image continuous use this adjunctive dietary type cancers, especially men. addition, discusses various pathways activated by eventually prevent suppress found effectively progression proliferation, arrest in-cell cycle, induce apoptosis cells both conditions. Additionally, showed it could modulate signaling their protein prevention

Language: Английский

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Lycopene in the Prevention of Cardiovascular Diseases

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 1957 - 1957

Published: Feb. 10, 2022

Cardiovascular diseases (CVDs) are the leading cause of human mortality worldwide. Oxidative stress and inflammation pathophysiological processes involved in development CVD. That is why bioactive food ingredients, including lycopene, so important their prevention, which seems to be a compound increasingly promoted diet people with cardiovascular problems. Lycopene present tomatoes tomato products responsible not only for red color but also health-promoting properties. It characterized by high antioxidant potential, highest among carotenoid pigments. Mainly this reason, epidemiological studies show number favorable properties between consumption lycopene reduced risk disease. While there some controversy research into its protective effects on system, growing evidence supports beneficial role heart, endothelium, blood vessels, health. The mechanisms action now being discovered may explain contradictions observed literature. This review aims current knowledge recent years preventive disorders.

Language: Английский

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