CD47 plays dual role in colorectal carcinoma, independently on CD 68: an immunohistochemical study DOI
Asmaa S. Mohamed,

Enas M. El Hosary,

Marwa Gadallah

et al.

Egyptian Journal of Pathology, Journal Year: 2024, Volume and Issue: 44(2), P. 91 - 101

Published: July 1, 2024

Background Colorectal cancer (CRC) is the third most common cancer. Tumor-associated macrophages can affect tumor cell proliferation, stromal formation and dissolution, vascularization, both pro- anti-neoplastic inflammation. Cluster of differentiation 68 (CD68) plays a critical role in promoting phagocytosis; however, its function immunity remains unknown. CD47, cell-surface receptor expressed by macrophages, provides potent ‘don’t eat me‘ signal that allows cells to evade immune destruction. Purpose Investigate immunohistochemical expression CD68 CD47 CRCs correlation with clinicopathological features. Results epithelial were significantly favor CRC ( P value = 0.001, <0.001, respectively) compared adenoma specimens. Also, high was associated absence gross perforation higher number investigated lymph. However, low correlated less metastasis recurrence. Moreover, epithelial, CRC. =0.033) Conclusion Both play colorectal carcinogenesis being more cases. carries good prognostic impact when contrary suggesting dual opposing according localization. So, future target therapy against or should be cautiously administered.

Language: Английский

Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

197
Increased cell senescence in human metabolic disorders DOI Creative Commons
Rosa Spinelli,

Ritesh K. Baboota,

Silvia Gogg

et al.

Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 133(12)

Published: June 14, 2023

Cell senescence (CS) is at the nexus between aging and associated chronic disorders, increases burden of CS in all major metabolic tissues. However, also increased adult obesity, type 2 diabetes (T2D), nonalcoholic fatty liver disease independent aging. Senescent tissues are characterized by dysfunctional cells inflammation, both progenitor mature, fully differentiated nonproliferating afflicted. Recent studies have shown that hyperinsulinemia insulin resistance (IR) promote human adipose cells. Similarly, promotes cellular IR, showing their interdependence. Furthermore, T2D age, BMI, degree hyperinsulinemia, suggesting premature These results suggest senomorphic/senolytic therapy may become important for treating these common disorders.

Language: Английский

Citations

45
The detrimental effects of micro-and nano-plastics on digestive system: An overview of oxidative stress-related adverse outcome pathway DOI

Ruiyang Ding,

Yiming Ma, Tianyu Li

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 878, P. 163144 - 163144

Published: March 30, 2023

Language: Английский

Citations

26
Metabolic homeostasis of tissue macrophages across the lifespan DOI
Stefanie K. Wculek, Stephan Forisch, Verónica Miguel

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(9), P. 793 - 808

Published: May 18, 2024

Language: Английский

Citations

7
Role of Iron in Aging Related Diseases DOI Creative Commons

William J. Chen,

George Kung,

Jaya P. Gnana‐Prakasam

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(5), P. 865 - 865

Published: April 28, 2022

Iron progressively accumulates with age and can be further exacerbated by dietary iron intake, genetic factors, repeated blood transfusions. While plays a vital role in various physiological processes within the human body, its accumulation contributes to cellular aging several species. In free form, initiate formation of radicals at level contribute systemic disorders. This is most evident high conditions such as hereditary hemochromatosis, when development arthritis, cirrhosis, or cardiomyopathy. A growing body research has identified iron's contributory effects neurodegenerative diseases, ocular disorders, cancer, diabetes, endocrine dysfunction, cardiovascular diseases. Reducing levels phlebotomy, chelation, restriction are common therapeutic considerations prevent toxicity. Chelators deferoxamine, deferiprone, deferasirox have become standard care managing overload other potential applications cancer cardiotoxicity. certain animal models, drugs chelating ability been found promote health even extend lifespan. As we explore process, chelators will likely play an increasingly important our health.

Language: Английский

Citations

24
Fast food consumption has a great impact on the aging process — A review DOI Creative Commons
Farhang Hameed Awlqadr, Ammar B. Altemimi, Syamand Ahmed Qadir

et al.

Theory and practice of meat processing, Journal Year: 2025, Volume and Issue: 10(1), P. 11 - 31

Published: April 6, 2025

This review examines the impact of fast food consumption on health and its role in development chronic diseases that accelerate aging process. A comprehensive literature was conducted to explore relationship between intake onset cardiovascular diseases, diabetes, cancer, obesity, all which are associated with premature aging. The findings indicate foods high fat sugar contribute inflammation — a phenomenon referred as “inflammageing”, damages vascular system heightens risk including atherosclerosis heart failure. Additionally, metabolic disorders such insulin resistance dyslipidemia disrupt glucose homeostasis, further exacerbating promoting accelerated Moreover, is linked an increased largely due presence carcinogenic compounds processed meats obesity epidemic, amplifies through mechanisms involving inflammation, oxidative stress, hormonal imbalances. Collectively, these factors impair immune function elevate neurodegenerative diseases. Consequently, significantly contributes by fostering disorders, stress. Urgent public interventions necessary mitigate adverse effects promote healthier dietary patterns, enhance quality life longevity.

Language: Английский

Citations

0
Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising? DOI Creative Commons

Christoph Hieber,

Stephan Grabbe, Matthias Bros

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(7), P. 1085 - 1085

Published: July 6, 2023

Aging attenuates the overall responsiveness of immune system to eradicate pathogens. The increased production pro-inflammatory cytokines by innate cells under basal conditions, termed inflammaging, contributes impaired towards pathogen-mediated stimulation and limits antigen-presenting activity. Adaptive responses are attenuated as well due lowered numbers naïve lymphocytes their antigen-specific stimulation. Additionally, immunoregulatory cell types, comprising regulatory T myeloid-derived suppressor cells, that inhibit activity adaptive elevated. This review aims summarize our knowledge on cellular molecular causes immunosenescence while also taking into account senescence effects constitute evasion mechanisms in case chronic viral infections cancer. For tumor therapy numerous nanoformulated drugs have been developed overcome poor solubility compounds enable cell-directed delivery order restore functions, e.g., addressing dysregulated signaling pathways. Further, nanovaccines which efficiently address mount sustained anti-tumor clinically evaluated. senolytics selectively deplete senescent being tested a number clinical trials. Here we discuss potential use such improve anti-aging therapy.

Language: Английский

Citations

11
Biological age prediction and NAFLD risk assessment: a machine learning model based on a multicenter population in Nanchang, Jiangxi, China DOI Creative Commons
Li Deng, Jing Huang,

Hang Yuan

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 13, 2025

Language: Английский

Citations

0
Impact of age on liver damage, inflammation, and molecular signaling pathways in response to femoral fracture and hemorrhage DOI Creative Commons

Fanshuai Meng,

Yuzhuo Zhou,

Alessa Wagner

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 24, 2023

Trauma causes disability and mortality globally, leading to fractures hemorrhagic shock. This can trigger an irregular inflammatory response that damages remote organs, including liver. Aging increases the susceptibility dysregulated immune responses following trauma, raising risk of organ damage, infections, higher morbidity in elderly patients. study investigates how aging affects liver inflammation damage post-trauma.24 male C57BL/6J mice were randomly divided into four groups. Twelve young (17-26 weeks) 12 aged (64-72 included. Mice further underwent either shock (trauma/hemorrhage, TH), femoral fracture (osteotomy) with external fixation (Fx) (THFx, n=6) or sham procedures (n=6). After 24 hours, sacrificed. Liver injury apoptosis evaluated using hematoxylin-eosin staining activated caspase-3 immunostaining. CXCL1 infiltrating polymorphonuclear leukocytes (PMNL) assessed by immunostaining, concentrations CXCL1, TNF, IL-1β, IL-10 tissue determined ELISA. Gene expression Tnf, Cxcl1, Il-1β, Cxcl2 was qRT-PCR. Finally, western blot used determine protein levels IκBα, Akt, their phosphorylated forms.THFx caused increased presence active caspase-3-positive cells compared corresponding group. THFx group had more severe than PMNL significantly both groups, a greater increase CXCL Pro-inflammatory TNF IL-1β elevated intensified THFx. Anti-inflammatory lower Tnf Cxcl1 gene enhanced Phosphorylation ratio IκBα versus THFx-induced phosphorylation reduced Akt group.The findings indicate may lead vulnerability trauma due responses.

Language: Английский

Citations

5
The Regulation of Bone Metabolism by the Liver DOI Creative Commons
Jing Luo, Yingting Zhang,

Yinkun Fu

et al.

Nature Cell and Science, Journal Year: 2024, Volume and Issue: 2(1), P. 1 - 9

Published: March 30, 2024

ent cells, even within the same lobule. 7mportantly, aging is a significant risk factor for various liver diseases, such as hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.Additionally, incidence of chronic disease increases with age associated AbstractChronic diseases osteoporosis, seemingly unrelated that occur advanced age, are involved in different mechanisms contributing to bone metabolic disorders.Secondary osteoporosis increased fragility common complications patients disease, including nonalcoholic fatty alcoholic cholestatic hepatitis.Despite these associations, intricate link between bones remains ambiguous.Here, we review current molecules liver-bone communication three aspects: factors liver, hepatic modifying enzymes, pro-inflammatory affected by metabolism.The emphasis on delineating regulation metabolism aim elucidating interplay processes.This exploration not only contributes better understanding dynamic relationship but also lays groundwork more comprehensive therapeutic strategies targeting disease.

Language: Английский

Citations

1