Surgery, Journal Year: 2024, Volume and Issue: 176(2), P. 274 - 281
Published: May 15, 2024
Language: Английский
Redox Biology, Journal Year: 2023, Volume and Issue: 67, P. 102894 - 102894
Published: Oct. 6, 2023
The present review summarizes the beneficial and detrimental roles of reactive oxygen species in myocardial ischemia/reperfusion injury cardioprotection. In first part, continued need for cardioprotection beyond that by rapid reperfusion acute infarction is emphasized. Then, pathomechanisms to myocardium coronary circulation different modes cell death are characterized. Different mechanical pharmacological interventions protect ischemic/reperfused elective percutaneous artery bypass grafting, cardiotoxicity from cancer therapy detailed. second part keeps focus on ROS providing a comprehensive overview molecular cellular mechanisms involved injury. Starting mitochondria as main sources targets myocardium, complex network extracellular processes discussed, including relationships with Ca2+ homeostasis, thiol group redox balance, hydrogen sulfide modulation, cross-talk NAPDH oxidases, exosomes, cytokines growth factors. While mechanistic insights needed improve our current therapeutic approaches, advancements knowledge ROS-mediated indicate facets oxidative stress opposed requirement physiological protective reactions. This inevitable contrast likely underlie unsuccessful clinical trials limits development novel cardioprotective simply based upon removal.
Language: Английский
Citations
47
Biomedicines, Journal Year: 2022, Volume and Issue: 10(9), P. 2274 - 2274
Published: Sept. 14, 2022
Diabetic patients are frequently affected by coronary microvascular dysfunction (CMD), a condition consisting of combination altered vasomotion and long-term structural change to arterioles leading impaired regulation blood flow in response changing cardiomyocyte oxygen requirements. The pathogenesis this complication is complex not completely known, involving several alterations among which hyperglycemia insulin resistance play particularly central roles oxidative stress, inflammatory activation barrier function endothelium. CMD significantly contributes cardiac events such as angina or infarction without obstructive artery disease, well heart failure, especially the phenotype associated with preserved ejection fraction, greatly impact cardiovascular (CV) prognosis. To date, no treatments specifically target vascular damage, but recent experimental studies some clinical investigations have produced data favor potential beneficial effects on micro vessels caused two classes glucose-lowering drugs: glucagon-like peptide 1 (GLP-1)-based therapy inhibitors sodium-glucose cotransporter-2 (SGLT2). purpose review describe pathophysiological mechanisms, manifestations particular reference diabetes, summarize protective antidiabetic drugs myocardial compartment.
Language: Английский
Citations
54
Health Sciences Review, Journal Year: 2023, Volume and Issue: 7, P. 100084 - 100084
Published: March 12, 2023
Endothelial dysfunction is characterized by a reduction in nitric oxide generation or an unbalanced distribution of the relaxing and contracting pressures produced endothelial cells. Endothelium was once assumed to be nothing more than mechanical barrier. now recognized as tissue that regulates tone, cell formation, leukocyte, thrombocyte, artery wall contact. The pathophysiologic pathways behind are great interest, researchers working hard figure out what they how affect diabetes, psoriasis, Inflammatory Bowel Disease, hypertension, heart failure, renal inflammation, stroke, atherosclerosis, oxidative stress. activation important processes progression pathogenesis atherosclerosis. psoriasis patients with arterial hypertension thought caused disturbance action L-oxidative arginine's metabolism, revealed decrease NO bioavailability high degree inactivation, stress, antioxidant state. failing characterised irregular cardiac vascular characteristics abnormalities In such conditions can increased various approaches like using generating compounds which done either through inhalation NO, use hybrid drugs oral NO-NSAIDs combination inorganic nitrites. On other hand endogenous levels direct delivery l‑arginine, l‑citrullineor Arginase inhibition. eNOS also activated statins, Corticosteroids, Second β-adrenoceptor antagonists increase level. This review will assist understanding dysfunction, its pathogenesis, connection variety disorders.
Language: Английский
Citations
36
Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11
Published: Oct. 25, 2023
The vascular endothelium is a multifunctional cellular system which directly influences blood components and cells within the vessel wall in given tissue. Importantly, this interface undergoes critical phenotypic changes response to various biochemical hemodynamic stimuli, driving several developmental pathophysiological processes. Multiple studies have indicated central role of initiation, progression, clinical outcomes cardiac disease. In review we synthesize current understanding endothelial function dysfunction as mediators cardiomyocyte phenotype setting distinct pathologies; outline existing
Language: Английский
Citations
27
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 14, 2024
Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Decoction created more than 700 years ago. SFI has been widely used in China for over 30 treating cardiovascular diseases. The main components it include ginsenosides aconitum alkaloids. In recent years, role treatment diseases attracted much attention. pharmacological effects therapeutic applications are summarized here, highlighting features potential mechanisms developments, confirming that can play multiple ways promising drug
Language: Английский
Citations
7
Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 664 - 664
Published: March 15, 2024
Osteonecrosis of the femoral head (ONFH) is a disabling disease characterized by disruption blood supply to head, leading apoptosis and necrosis bone cells subsequent joint collapse. Total hip arthroplasty not optimal since most patients are young. Multiple risk factors contribute osteonecrosis, including glucocorticoid (GC) usage, excessive alcohol intake, hypercholesterolemia, smoking. Continuous stimulation many variables causes chronic inflammatory milieu, with clinical repercussions endothelial dysfunction, thrombosis, coagulopathy, poor angiogenesis. Immune primary regulators inflammation. Innate adaptive immune interact hinder regeneration repair lesions. An in-depth examination pathological drivers ONFH reveals that dysfunction may be major cause osteonecrosis. Understanding involvement in inflammation osteonecrosis could aid development possible therapies. This review summarizes role further explains pathophysiological mechanism this from perspective provide new ideas for treatment
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7548 - 7548
Published: July 7, 2022
The endothelium has multiple functions, ranging from maintaining vascular homeostasis and providing nutrition oxygen to tissues evocating inflammation under adverse conditions determining endothelial barrier disruption, resulting in dysfunction. Endothelial dysfunction represents a common condition associated with the pathogenesis of all diseases cardiovascular system, as well other systems human body, including sepsis, acute respiratory distress syndrome, COVID-19 distress. Such evidence is leading identification potential biomarkers therapeutic targets for preserving, reverting, or restoring integrity functionality by promptly treating its Here, some strategies achieving these goals are explored, despite diverse challenges that exist, necessitating significant bench work an increased number clinical studies.
Language: Английский
Citations
23
The American Journal of Medicine, Journal Year: 2024, Volume and Issue: 137(9), P. 810 - 817
Published: Sept. 1, 2024
Language: Английский
Citations
4
Journal of Surgical Research, Journal Year: 2025, Volume and Issue: 309, P. 146 - 155
Published: April 19, 2025
Language: Английский
Citations
0
Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 400 - 400
Published: Feb. 8, 2024
The therapeutic management of atherosclerosis focuses almost exclusively on the reduction plasma cholesterol levels. An important role in genesis and evolution is played by chronic inflammation promoting thrombosis phenomena after atheroma rupture. This review aims to take stock knowledge so far accumulated endemic HP infection atherosclerosis. studies produced have demonstrated a causal relationship between Helicobacter pylori (HP) CVD. In previous study, we HP-positive patients that thrombin fragment 1 + 2 production was proportionally related tumor necrosis factor-alpha levels eradication resulted inflammation. At end our review, can state slightly affects risk CVD, particularly if associated with cytotoxic damage, screening could clinically significant high Considering prevalence infection, an be great clinical utility at
Language: Английский
Citations
3