GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway DOI Creative Commons
Xueqin Hou, Cuiping Rong, Fugang Wang

et al.

Neural Plasticity, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 11

Published: Aug. 1, 2020

Stress can cause a variety of central nervous system disorders, which are critically mediated by the γ -aminobutyric acid (GABA) in various brain structures. GABAergic neurons have different subsets, some coexpress certain neuropeptides that be found digestive system. Accumulating evidence demonstrates gut-brain axis, is primarily regulated vagus nerve, involved stress, suggesting communication between “gut-vagus-brain” pathway and neuronal Here, we first summarize plays an essential role stress responses. In addition, review effects on regions neuron subpopulations, including somatostatin, parvalbumin, ionotropic serotonin receptor 5-HT3a, cholecystokinin, neuropeptide Y, vasoactive intestinal peptide, with regard to signaling events, behavioral changes, pathobiology neuropsychiatric diseases. Finally, discuss bidirectional communications connection gut-vagus-brain pathway.

Language: Английский

The Microbiota-Gut-Brain Axis DOI Open Access
John F. Cryan, Kenneth J. O’Riordan, Caitlin S.M. Cowan

et al.

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 1877 - 2013

Published: Aug. 28, 2019

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric

Language: Английский

Citations

3485
The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective DOI
Sofia Cussotto,

Kiran V. Sandhu,

Timothy G. Dinan

et al.

Frontiers in Neuroendocrinology, Journal Year: 2018, Volume and Issue: 51, P. 80 - 101

Published: May 16, 2018

Language: Английский

Citations

275
When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis DOI Creative Commons
Emily M. Teichman, Kenneth J. O’Riordan, Cormac G. M. Gahan

et al.

Cell Metabolism, Journal Year: 2020, Volume and Issue: 31(3), P. 448 - 471

Published: March 1, 2020

Language: Английский

Citations

145
The microbiota–gut–brain axis and neurodevelopmental disorders DOI Creative Commons
Qinwen Wang,

Qianyue Yang,

Xingyin Liu

et al.

Protein & Cell, Journal Year: 2023, Volume and Issue: 14(10), P. 762 - 775

Published: May 11, 2023

Abstract The gut microbiota has been found to interact with the brain through microbiota–gut–brain axis, regulating various physiological processes. In recent years, impacts of on neurodevelopment this axis have increasingly appreciated. is commonly considered regulate three pathways, immune pathway, neuronal and endocrine/systemic overlaps crosstalks in between. Accumulating studies identified role neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity Rett Syndrome. Numerous researchers examined pathophysiological mechanisms influenced by (NDDs). This review aims provide a comprehensive overview advancements research pertaining microbiota-gut-brain NDDs. Furthermore, we analyzed both current state progress discuss future perspectives field.

Language: Английский

Citations

118
Gut microbiota in Alzheimer’s disease: Understanding molecular pathways and potential therapeutic perspectives DOI

Simone Lista,

Antonio Munafò, Filippo Caraci

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102659 - 102659

Published: Jan. 10, 2025

Language: Английский

Citations

3
Interoception and disordered eating: A systematic review DOI
Elizabeth Martin, Colin T. Dourish, Pia Rotshtein

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2019, Volume and Issue: 107, P. 166 - 191

Published: Aug. 24, 2019

Language: Английский

Citations

88
The ins and outs of the caudal nucleus of the solitary tract: An overview of cellular populations and anatomical connections DOI
Marie K. Holt

Journal of Neuroendocrinology, Journal Year: 2022, Volume and Issue: 34(6)

Published: March 29, 2022

The body and brain are in constant two-way communication. Driving this communication is a region the lower brainstem: dorsal vagal complex. Within complex, caudal nucleus of solitary tract (cNTS) major first stop for incoming information from to carried by vagus nerve. anatomy makes it ideally positioned respond signals change both emotional bodily states. In turn, cNTS controls activity regions throughout that involved control behaviour physiology. This review intended help anyone with an interest cNTS. First, I provide overview architecture outline wide range neurotransmitters expressed subsets neurons Next, detail, discuss known inputs outputs briefly highlight what regarding neurochemical makeup function those connections. Then, one group neurons: glucagon-like peptide-1 (GLP-1)-expressing neurons. GLP-1 serve as good example neurons, which receive input varied sources have ability modulate Finally, consider we might learn about other our study why important remember manipulation molecularly defined likely affect physiology behaviours beyond monitored individual experiments.

Language: Английский

Citations

42
The gut-brain axis and cognitive control: A role for the vagus nerve DOI
Léa Décarie-Spain, Anna Hayes,

Logan Tierno Lauer

et al.

Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 156, P. 201 - 209

Published: Feb. 16, 2023

Language: Английский

Citations

37
Non‐Invasive Auricular Vagus Nerve Stimulation Decreases Heart Rate Variability Independent of Caloric Load DOI Creative Commons
Kristin Kaduk, A. Petrella, Sophie J. Müller

et al.

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(2)

Published: Feb. 1, 2025

ABSTRACT The vagus nerve is crucial in regulating physiological functions, including the cardiovascular system. While heart rate (HR) and its variability (HRV) may provide non‐invasive proxies of cardiac vagal activity, transcutaneous auricular stimulation (taVNS) has yielded mixed effects, with limited research on right branch stimulation. In a randomized crossover study 36 healthy participants, we investigated taVNS effects HR HRV indexed by SDRR, RMSSD, HF‐HRV, LF/HF ratio. To assess impact side (left vs. ear) indices interaction state, recorded electrocardiograms four sessions per person, covering three session phases: baseline, during (taVNS sham), post‐milkshake consumption First, found moderate evidence against affecting (BF 10 = 0.21). Second, decreased (multivariate p 0.004) independent strong for RMSSD 15.11) HF‐HRV 11.80). Third, taVNS‐induced changes were comparable across sides stronger than sham, indicating consistent side. We conclude that reduces as SDRR without altering HR, contradicting assumption se increases cardiovagal activity increased due to stimulating afferents. Instead, our results support role afferent activation arousal. Crucially, both can safely modulate system increasing risk bradycardia or causing adverse events offering new treatment possibilities.

Language: Английский

Citations

1
Diet induces parallel changes to the gut microbiota and problem solving performance in a wild bird DOI Creative Commons
Gabrielle L. Davidson,

Niamh Wiley,

Amy C. Cooke

et al.

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Nov. 27, 2020

Abstract The microbial community in the gut is influenced by environmental factors, especially diet, which can moderate host behaviour through microbiome-gut-brain axis. However, ecological relevance of microbiome-mediated behavioural plasticity wild animals unknown. We presented wild-caught great tits ( Parus major ) with a problem-solving task and showed that performance was weakly associated variation microbiome. then manipulated microbiome feeding birds one two diets differed their relative levels fat, protein fibre content: an insect diet (low content), or seed (high content). Microbial communities were less diverse among individuals given compared to those on diet. Individuals likely problem-solve after being same microbiota metrics altered as consequence also correlated problem solving performance. Although effect could have been caused motivational nutritional differences between our treatments, results nevertheless raise possibility dietary induced changes be important mechanism underlying individual populations.

Language: Английский

Citations

69