Blood Inflammatory Markers and Cytokines in COVID‐19 Patients With Bacterial Coinfections DOI Creative Commons

Qingqing Bi,

Jie Zhu,

Jinju Zheng

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(12)

Published: Dec. 1, 2024

ABSTRACT Background Bacterial coinfection in patients with SARS‐CoV‐2 infection is an important risk factor for death. This study investigated whether there were differences levels of serum inflammatory markers COVID‐19 bacterial coinfections compared those without infection. Methods A total 235 inpatients admitted to Qingdao Central Hospital from December 7, 2022, August 2024, included. Patients divided into a bacteria‐positive group (115 cases) and bacteria‐negative (120 according they had coinfections. PCT, CRP, 12 kinds cytokines between groups, the distribution species positive was statistically analyzed. Results The CRP ( Z = 8.94, p < 0.001), PCT 5.59, IL‐1β t 4.863, IL‐2 5.810, IL‐5 3.837, IL‐6 4.910, IL‐8 3.325, ILIL‐12p70 4.722, IL‐17 3.315, 0.001) TNF‐α 4.251, two groups significantly different. IL‐4, IL‐10, IFN‐α, IFN‐γ not significant > 0.05). Among 115 patients, 56 one 59 multiple infections. Acinetobacter baumannii , Klebsiella pneumoniae, Pseudomonas aeruginosa Staphylococcus aureus, Haemophilus influenzae common species. Conclusions Serum are higher than Cytokines such as IL‐1β, IL‐2, IL‐5, IL‐6, IL‐8, IL‐12p70, IL‐17, may be involved progression combined They can used potential evaluate disease condition prognosis.

Language: Английский

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions DOI Creative Commons
Yong Qiu, Chunheng Mo, Lu Chen

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(4)

Published: March 15, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 deaths. Patients with disease (COVID-19) may suffer from diarrhea, sleep disorders, depression, even cognitive impairment, which is associated long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients COVID-19 alterations microbiota their metabolites, particularly the gut, be involved regulation of immune responses. Consumption probiotics alleviate discomfort by inflammation oxidative stress. pathophysiological process underlying alleviation COVID-19-related symptoms complications targeting unclear. In current study, we summarize latest research evidence together SARS-CoV-2 vaccine use, focus relationship between use. This work provides probiotic-based interventions improve regulating gut systemic immunity. Probiotics also used as adjuvants to efficacy.

Language: Английский

Citations

7
ANESTHESIA, PAIN MANAGEMENT, AND PUBLIC HEALTH: A REVIEW OF TECHNIQUES AND STRATEGIES FOR COINFECTED PATIENTS DOI Creative Commons

Chioma Anthonia Okolo,

Oloruntoba Babawarun,

Tolulope Olorunsogo

et al.

International Medical Science Research Journal, Journal Year: 2024, Volume and Issue: 4(3), P. 247 - 258

Published: March 17, 2024

Coinfections, particularly in patients with HIV, hepatitis C, or tuberculosis, present complex challenges anesthesia and pain management. This review examines the unique considerations, techniques, strategies for providing safe effective care to this vulnerable population. It explores impact of coinfections on outcomes, role multidisciplinary approaches, implications public health. Patients often have medical histories, including comorbidities compromised immune systems, which can affect their response Strategies such as preoperative optimization, tailored anesthetic plans, close monitoring are crucial mitigate risks ensure positive outcomes. Multidisciplinary collaboration is essential managing coinfections, involving anesthesiologists, infectious disease specialists, surgeons, other healthcare professionals. approach allows comprehensive that addresses needs coinfected patients. Public health management significant, they resource utilization, treatment overall costs. Understanding implementing lead improved outcomes In conclusion, management, requiring approaches collaboration. By addressing these challenges, providers improve contribute better overall. Keywords: Anesthesia, Pain Management, Health, Techniques, Coinfected Patients.

Language: Английский

Citations

4
COVID-19 complicated with severe M1UK-lineage Streptococcus pyogenes infection in elderly patients: A report of two cases. DOI Creative Commons
Atsushi Kawaguchi, Kentaro Nagaoka, Hitoshi Kawasuji

et al.

International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 148, P. 107246 - 107246

Published: Sept. 19, 2024

Case 1: A 71-year-old man was admitted to our hospital with progressive fever and dyspnea, which had developed three days after the onset of COVID-19. Initial chest computed tomography (CT) revealed a pulmonary lesion consistent secondary bacterial infection. Streptococcus pyogenes isolated from cultures primary sputum collected endotracheal tube, identified as causative microorganism. 2: 91-year-old transferred severe hypotension, nine CT pericardial effusion pericardiocentesis yielded purulent fluid. S. fluid specimens microorganism pericarditis. Isolates both patients were subsequently M1

Language: Английский

Citations

4
Disease X: Unraveling a mysterious outbreak in the Democratic Republic of the Congo DOI Creative Commons
Manish Verma, Amogh Verma,

Rahul Singla

et al.

Clinical Infection in Practice, Journal Year: 2025, Volume and Issue: unknown, P. 100409 - 100409

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effect of COVID-19 on infections associated with medical devices in critical care DOI Creative Commons
Fredy Leonardo Carreño Hernández,

Juanita Valencia Virguez,

Juan Felipe González Vesga

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 22, 2024

Abstract Objectives This study explores the hypothesis that COVID-19 patients are at a heightened risk of healthcare-associated infections (HAIs) associated with medical device usage compared to non-COVID-19 patients. Our primary objective was investigate correlation between infection in ICU and subsequent HAIs following invasive insertion. Additionally, we aim assess impact SARS-CoV-2 on onset times concerning specific microorganisms type device, providing valuable insights into this intricate relationship intensive care settings. Methodology A retrospective cohort conducted using patient records our hospital from 2020 2022. investigation entailed evaluating timing while distinguishing without infection. We identified analyzed isolation attributed controlling for duration ventilator days Cox regression. Results included 127 140 The findings indicated higher incidence HAI caused by various any (HR = 6.86; 95% CI-95%: 3.26–14.43; p < 0.01). After adjusting days, frequency persisted SARS-CoV-2-infected individuals. However, detailed examination revealed only ventilation-associated pneumonia (VAP) displayed significant association 6.69; CI: 2.59–17.31; statistically S. aureus also observed ( 0.034). prevalence notably (RR 8.080; 1.052–62.068; Conclusions pathogen isolates devices exhibited an Critically ill more prone developing early-onset VAP than those

Language: Английский

Citations

1
Comparison of clinical characteristics and severity of COVID-19 with or without viral co-infection in hospitalized children DOI
Kensuke Shoji, Yusuke Asai,

Shinya Tsuzuki

et al.

Journal of Infection and Chemotherapy, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

1
Blood Inflammatory Markers and Cytokines in COVID‐19 Patients With Bacterial Coinfections DOI Creative Commons

Qingqing Bi,

Jie Zhu,

Jinju Zheng

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(12)

Published: Dec. 1, 2024

ABSTRACT Background Bacterial coinfection in patients with SARS‐CoV‐2 infection is an important risk factor for death. This study investigated whether there were differences levels of serum inflammatory markers COVID‐19 bacterial coinfections compared those without infection. Methods A total 235 inpatients admitted to Qingdao Central Hospital from December 7, 2022, August 2024, included. Patients divided into a bacteria‐positive group (115 cases) and bacteria‐negative (120 according they had coinfections. PCT, CRP, 12 kinds cytokines between groups, the distribution species positive was statistically analyzed. Results The CRP ( Z = 8.94, p < 0.001), PCT 5.59, IL‐1β t 4.863, IL‐2 5.810, IL‐5 3.837, IL‐6 4.910, IL‐8 3.325, ILIL‐12p70 4.722, IL‐17 3.315, 0.001) TNF‐α 4.251, two groups significantly different. IL‐4, IL‐10, IFN‐α, IFN‐γ not significant > 0.05). Among 115 patients, 56 one 59 multiple infections. Acinetobacter baumannii , Klebsiella pneumoniae, Pseudomonas aeruginosa Staphylococcus aureus, Haemophilus influenzae common species. Conclusions Serum are higher than Cytokines such as IL‐1β, IL‐2, IL‐5, IL‐6, IL‐8, IL‐12p70, IL‐17, may be involved progression combined They can used potential evaluate disease condition prognosis.

Language: Английский

Citations

1