Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: June 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Language: Английский

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Catalase‐Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

Small, Journal Year: 2022, Volume and Issue: 18(37)

Published: Aug. 15, 2022

The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)-like nanozyme, acting as an essential part regulation reactive oxygen species (ROS), attracted extensive research interest in recent years. However, CAT-like are not well discussed other such peroxidase (POD)-like nanozymes, etc. Compared with natural or artificial CAT enzymes, have unique properties low cost, size-dependent properties, high catalytic activity and stability, easy surface modification, etc., which make them widely used fields, especially tumor therapy disease treatment. Consequently, there is a great requirement to systematic discussion on nanozymes. In this review, some key aspects deeply summarized as: 1) Typical classified by different nanomaterials; 2) mechanisms proposed experimental theoretical studies; 3) Extensive applications regard therapy, cytoprotection sensing. Therefore, it prospected that review will contribute further design optimize their much higher efficiency than before.

Language: Английский

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Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12567 - 12603

Published: Aug. 2, 2021

Immunotherapy that harnesses the human immune system to fight cancer has received widespread attention and become a mainstream strategy for treatment. Cancer immunotherapy not only eliminates primary tumors but also treats metastasis recurrence, representing major advantage over traditional treatments. Recently with development of nanotechnology, there exists much work applying nanomaterials on basis their excellent physiochemical properties, such as efficient tissue-specific delivery function, huge specific surface area, controllable chemistry. Consequently, nanotechnology holds significant potential in improving efficacy immunotherapy. Nanotechnology-based mainly manifests its inhibitory effect via two different approaches: one is produce an effective anti-tumor response during tumorigenesis, other enhance tumor defense ability by modulating suppression mechanism microenvironment. With success immunotherapy, understanding interaction between smart nanomedicine provided vigorous vitality This review highlights application, progress, prospect process immunoediting discusses several engineering methods improve efficiency

Language: Английский

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Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma

Theranostics, Journal Year: 2021, Volume and Issue: 11(11), P. 5464 - 5490

Published: Jan. 1, 2021

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one leading causes cancer-related death worldwide. Advanced HCC displays strong resistance to chemotherapy, traditional chemotherapy drugs do not achieve satisfactory therapeutic efficacy. Sorafenib an oral kinase inhibitor that inhibits tumor cell proliferation angiogenesis induces apoptosis. It also improves survival rates patients with advanced cancer. However, due its poor solubility, fast metabolism, low bioavailability, clinical applications sorafenib have been substantially restricted. In recent years, various studies conducted on use nanoparticles improve drug targeting efficacy in HCC. Moreover, extensively explored sorafenib, a variety nanoparticles, such as polymer, lipid, silica, metal developed for treating All these new technologies improved targeted treatment by promoted nanomedicines treatments This review provides overview hot topics nanoscience latest status further introduces current research nanoparticle delivery systems sorafenib.

Language: Английский

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Biomimetic Nanoemulsion for Synergistic Photodynamic‐Immunotherapy Against Hypoxic Breast Tumor

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(19), P. 10647 - 10653

Published: Feb. 8, 2021

Photodynamic therapy (PDT) is commonly used as an "in situ vaccine" to enhance the response rate of PD-1/PD-L1 antibodies. Unfortunately, high cost and adverse effects these antibodies, hypoxic state solid tumors limits efficacy synergistic photodynamic-immunotherapy. Here, we developed a biomimetic nanoemulsion camouflaged with PD-1-expressing cell membrane for photodynamic-immunotherapy against breast tumors. The perfluorocarbon could provide oxygen source PDT Moreover, co-delivering photosensitizer PD-1 protein (substituting PD-L1 antibody) achieves synergy effect immunotherapy. Synergistic completely inhibited primary distant subcutaneous 4T1 tumors, mechanistically by boosting maturation dendritic cells tumor infiltration cytotoxic T lymphocytes.

Language: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

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Combined Photodynamic and Photothermal Therapy and Immunotherapy for Cancer Treatment: A Review

International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 6427 - 6446

Published: Dec. 1, 2022

Photoactivation therapy based on photodynamic (PDT) and photothermal (PTT) has been identified as a tumour ablation modality for numerous cancer indications, with photosensitisers conversion agents playing important roles in the phototherapy process, especially recent decades.In addition, iteration of nanotechnology strongly promoted development treatment.PDT can increase sensitivity cells to PTT by interfering microenvironment, whereas heat generated blood flow, improve oxygen supply enhance PDT therapeutic effect.In cell debris serve tumour-associated antigens, evoking antitumor immune responses.In this review, research progress phototherapy, its effects combination immunotherapy treatment tumours are mainly outlined, issues that may need continued attention future raised.

Language: Английский

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Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma

Redox Biology, Journal Year: 2022, Volume and Issue: 54, P. 102351 - 102351

Published: May 28, 2022

The nonnegligible reason for the poor prognosis of hepatocellular carcinoma (HCC) is resistance to conventional chemotherapy. Immunogenic cell death (ICD) a rare immunostimulatory form that can reengage tumor-specific immune system. ICD improve clinical outcomes chemotherapeutics by promoting long-term cancer immunity. discovery potential inducers emerging as promising direction. In present study, micheliolide (MCL), natural guaianolide sesquiterpene lactone, was screened out virtual screening strategies, identified an inhibitor thioredoxin reductase (TrxR) and evaluated have high induce ICD. Here, we showed MCL induced ICD-associated DAMPs (damage-associated molecular patterns, such CRT exposure, ATP secretion HMGB1 release). significantly triggered regression established tumors in immunocompetent mouse vaccine model, (DCs maturation, stimulation CD4+, CD8+ T-cells responses) vivo. Mechanistically, found magnitude effects upon exposure HCC cells dependent on generation reactive oxygen species (ROS)-mediated endoplasmic reticulum stress (ERS). addition, suppression ROS normalized MCL-induced ERS, contrast, downregulation TrxR synergized with ERS driven MCL. We also systematically detected H2O2 using Hyper7 sensors exposed Notably, inhibited development organoids. Collectively, our results reveal association between inhibitors ICD, presenting valuable insights into MCL-activated cells.

Language: Английский

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NIR-II light in clinical oncology: opportunities and challenges

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(6), P. 449 - 467

Published: May 1, 2024

Language: Английский

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Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(29)

Published: June 9, 2023

Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.

Language: Английский

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