Perspectives for Uses of Propolis in Therapy against Infectious Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(14), P. 4594 - 4594

Published: July 19, 2022

Propolis has gained wide popularity over the last decades in several parts of world. In parallel, literature about propolis composition and biological properties increased markedly. A great number papers have demonstrated that from different world is composed mainly phenolic substances, frequently flavonoids, derived plant resins. a relevant role increasing social immunity bee hives. Experimental evidence indicates its components activity against bacteria, fungi, viruses. Mechanisms action on viruses are known for components. Experiments shown may act synergistically with antibiotics, antifungals, antivirus drugs, permitting administration lower doses drugs higher antimicrobial effects. The current trend growing resistance microbial pathogens to available encouraged introduction therapy infectious diseases. Because widely variable, standardized extracts been produced. Successful clinical trials included as medicine dentistry an adjuvant treatment patients COVID-19. Present health conditions encourage initiatives toward spread niche propolis, not only traditional alternative but also protagonist anti-infectious therapy. Production other apiary products environmentally friendly contribute alleviating crisis decline populations. production had social-economic relevance Brazil, providing benefits underprivileged people.

Language: Английский

---

How diverse is the chemistry and plant origin of Brazilian propolis?

Apidologie, Journal Year: 2021, Volume and Issue: 52(6), P. 1075 - 1097

Published: Oct. 1, 2021

Language: Английский

---

The Effects of Propolis on Viral Respiratory Diseases

Molecules, Journal Year: 2023, Volume and Issue: 28(1), P. 359 - 359

Published: Jan. 1, 2023

Propolis remains an interesting source of natural chemical compounds that show, among others, antibacterial, antifungal, antiviral, antioxidative and anti-inflammatory activities. Due to the growing incidence respiratory tract infections caused by various pathogenic viruses, complementary methods prevention therapy supporting pharmacotherapy are constantly being sought out. The properties propolis may be important in treatment diseases viruses such as severe acute syndrome coronavirus 2, influenza parainfluenza virus rhinoviruses. One main challenges recent years has been 2 (SARS-CoV-2), causing COVID-19. Recently, increasing number studies focusing on activity preparations against SARS-CoV-2 adjuvant for this infection. shown a few key mechanisms anti-SARS-CoV-2 action as: inhibition interaction S1 spike protein ACE-2 protein; decreasing replication diminishing synthesis RNA transcripts cells; particles coronaviruses. anti-viral effect is observed not only with extracts but also single biologically active found (e.g., apigenin, caffeic acid, chrysin, kaempferol, quercetin). Moreover, effective hyperglycemia, which increases risk infections. aim literature review was summarize from PubMed database evaluating antiviral terms (in vitro, vivo, clinical trials). Based upon review, it have focused mainly assessment effectiveness its components exerts wide-spectrum antimicrobial activities; thus, can option co-infections associated tract.

Language: Английский

---

Propolis Use in Dentistry: A Narrative Review of Its Preventive and Therapeutic Applications

International Dental Journal, Journal Year: 2024, Volume and Issue: 74(3), P. 365 - 386

Published: Feb. 19, 2024

Propolis is a resinous substance produced naturally by bees, and it consists of the exudates plants mixed with enzymes, wax, pollen. continues to gain considerable scientific interest due its potential health benefits. The modern-day use propolis in pharmaceutical preparations, such as toothpastes, mouthwashes, chewable tablets, mucoadhesive gels, sprays, increasing. However, effectiveness using propolis-containing pharmaceuticals dentistry not clear. present paper aims review literature on dental applications preventive dentistry, periodontics, oral medicine, restorative discuss clinical effectiveness. A search was conducted Scopus, PubMed, Web Science databases. In total, 104 studies were included, which 46 laboratory studies, 5 animal 53 human studies. Overall, revealed range antimicrobial effects pathogens. Clinical investigations biofilm caries control well adjuvant periodontal therapies reported positive outcomes terms plaque control, pathogenic microbial count reduction, tissue inflammation control. Additional included for management recurrent aphthous stomatitis, mucositis, cavity disinfection after removal development materials. Based usage has potential. majority evidence derived from flaws their methodological design, making results conclusions questionable. As consequence, properly designed well-reported are required affirm applications. Additionally, safety optimal concentrations extraction methods warrant further investigation. Utilisation standardised extracts will help quality propolis-based products lead achievement reproducible research

Language: Английский

---

Is Propolis a Potential Anti-Obesogenic Agent for Obesity?

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(2), P. 186 - 193

Published: March 4, 2024

Abstract Purpose of Review Propolis is a bee product that has been used for thousands years. The chemical composition and biological activity propolis, which investigated in the twentieth century, may vary according to location. polyphenols can induce thermogenesis brown beige fat tissue via uncoupled protein-1 creatinine kinase metabolic pathways. This review provides comprehensive investigation structural properties propolis insights into their promising potential strategies body weight management. Recent Findings By raising overall energy expenditure, it might lead Furthermore, phenolic components artepillin C, quercetin, catechin, chlorogenic acid found its have anti-obesogenic effect by stimulating sympathetic nervous system, enhancing browning white adipose tissue, triggering AMP-activated protein activation mitochondrial biogenesis. Summary Propolis, natural product, effective preventing obesity contemporary pandemic.

Language: Английский

---