Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(4), P. 542 - 542
Published: April 4, 2022
Persistent
hyperglycemic
state
in
type
2
diabetes
mellitus
leads
to
the
initiation
and
progression
of
non-enzymatic
glycation
reaction
with
proteins
lipids
nucleic
acids.
Glycation
generation
a
heterogeneous
group
chemical
moieties
known
as
advanced
glycated
end
products
(AGEs),
which
play
central
role
pathophysiology
diabetic
complications.
The
engagement
AGEs
its
chief
cellular
receptor,
RAGE,
activates
myriad
signaling
pathways
such
MAPK/ERK,
TGF-β,
JNK,
NF-κB,
leading
enhanced
oxidative
stress
inflammation.
downstream
consequences
AGEs/RAGE
axis
involve
compromised
insulin
signaling,
perturbation
metabolic
homeostasis,
RAGE-induced
pancreatic
beta
cell
toxicity,
epigenetic
modifications.
instigated
modulation
gene
transcription
is
profoundly
associated
pathogenesis
In
this
review,
we
will
summarize
exogenous
endogenous
sources
AGEs,
their
dysfunction,
current
understandings
cascade.
focus
review
recapitulate
Furthermore,
present
an
overview
future
perspectives
offer
new
therapeutic
interventions
intervene
pathway
slow
down
diabetes-related
Nutrients,
Journal Year:
2021,
Volume and Issue:
14(1), P. 166 - 166
Published: Dec. 30, 2021
The
gut
microbiota
has
been
linked
to
the
emergence
of
obesity,
metabolic
syndrome
and
onset
type
2
diabetes
through
decreased
glucose
tolerance
insulin
resistance.
Uncontrolled
can
lead
serious
health
consequences
such
as
impaired
kidney
function,
blindness,
stroke,
myocardial
infarction
lower
limb
amputation.
Despite
a
variety
treatments
currently
available,
cases
resulting
complications
are
on
rise.
One
promising
new
approach
focuses
modulating
with
probiotics,
prebiotics,
synbiotics
fecal
microbial
transplantation.
Differences
in
composition
have
observed
preclinical
animal
models
well
patients
diabetic
nephropathy,
retinopathy,
neuropathy,
cerebrovascular
disease,
coronary
heart
disease
peripheral
artery
compared
healthy
controls.
Severity
dysbiosis
was
associated
severity
restoration
probiotic
administration
human
improvement
symptoms
progression.
Characterizing
different
diseases
determining
causal
relationship
between
be
beneficial
formulating
therapeutic
interventions
for
complications.
In
this
review,
we
present
most
important
findings
regarding
role
chronic
their
underlying
mechanisms.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2019,
Volume and Issue:
2019, P. 1 - 19
Published: March 10, 2019
The
prevalence
of
cardiovascular
disease
(CVD)
is
increasing
over
time.
CVD
a
comorbidity
in
diabetes
and
contributes
to
premature
death.
Citrus
flavonoids
possess
several
biological
activities
have
emerged
as
efficient
therapeutics
for
the
treatment
CVD.
scavenge
free
radicals,
improve
glucose
tolerance
insulin
sensitivity,
modulate
lipid
metabolism
adipocyte
differentiation,
suppress
inflammation
apoptosis,
endothelial
dysfunction.
intake
citrus
has
been
associated
with
improved
outcomes.
Although
exerted
multiple
beneficial
effects,
their
mechanisms
action
are
not
completely
established.
In
this
review,
we
summarized
recent
findings
advances
understanding
underlying
protective
effects
against
oxidative
stress,
inflammation,
diabetes,
dyslipidemia,
dysfunction,
atherosclerosis.
Further
studies
clinical
trials
assess
efficacy
explore
mechanism(s)
recommended.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(14), P. 7644 - 7644
Published: July 16, 2021
Many
approaches
have
been
used
in
the
effective
management
of
type
2
diabetes
mellitus.
A
recent
paradigm
shift
has
focused
on
role
adipose
tissues
development
and
treatment
disease.
Brown
(BAT)
white
(WAT)
are
two
main
types
with
beige
subsets
more
recently
identified.
They
play
key
roles
communication
insulin
sensitivity.
However,
WAT
shown
to
contribute
significantly
endocrine
function.
produces
hormones
cytokines,
collectively
called
adipocytokines,
such
as
leptin
adiponectin.
These
adipocytokines
proven
vary
conditions,
metabolic
dysfunction,
diabetes,
or
inflammation.
The
regulation
fat
storage,
energy
metabolism,
satiety,
release
all
features
tissues.
As
such,
they
indicators
that
may
provide
insights
dysfunction
can
be
considered
routes
for
therapeutic
considerations.
essential
vis-a-vis
appetite,
storage
energy,
glucose
tolerance,
release,
solidifies
tissue
pathogenesis
mellitus
complications
associated
ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(3), P. 3299 - 3315
Published: Feb. 12, 2020
Due
to
the
inability
spontaneously
heal
and
vulnerability
bacterial
infection,
diabetic
patients
are
frustrated
by
unexpected
epithelium
injuries
in
daily
life.
Notably,
a
drug-resistant
infection
may
result
long-term
impact
natural
function
of
damaged
organs.
It
is
imperative
develop
strategies
that
promote
injury
recovery
eradicate
simultaneously.
Here,
we
present
composite
structured
cupriferous
hollow
nanoshell
(AuAgCu2O
NS)
consists
gold-silver
(AuAg)
core
Cu2O
shell
as
photothermal
therapeutic
agent
for
cutaneous
chronic
wound
nonhealing
keratitis
with
infection.
The
controllable
effect
released
silver
ion
from
AuAg
possess
synergistic
multi-drug-resistant
bacteria,
including
extended-spectrum
β-lactamase
Escherichia
coli
(ESBL
E.
coli)
methicillin-resistant
Staphylococcus
aureus
(MRSA).
Meanwhile,
copper
could
expedite
endothelial
cell
angiogenesis
fibroblast
migration,
thus
boosting
wound-healing
effects.
In
both
infection-complicated
disease
models,
ophthalmic
clinical
score,
closure
rates,
histopathology
analysis
demonstrate
AuAgCu2O
NSs
facilitate
re-epithelialization
at
area
eliminate
complicated
mice.
A
primary
signal
path
involved
promoted
healing
was
further
illustrated
comprehensive
assays
immunohistochemical
evaluation,
Western
blot,
quantitative
polymerase
chain
reaction.
Taken
together,
our
shown
be
potent
candidates
utilization
treatment
injuries.
Cardiovascular Diabetology,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: Jan. 7, 2021
Abstract
Diabetes
mellitus
is
the
major
risk
factor
for
development
of
macrovascular
and
microvascular
complications.
It
increasingly
recognized
that
glycemic
variability
(GV),
referring
to
oscillations
in
blood
glucose
levels
representing
either
short-term
or
long-term
GV,
involved
pathogenesis
diabetic
complications
has
emerged
as
a
possible
independent
them.
In
this
review,
we
summarize
metrics
measurement
GV
clinical
practice,
well
comprehensively
elaborate
role
related
mechanisms
complications,
aiming
provide
mechanism-based
therapeutic
strategies
clinicians
manage
diabetes
mellitus.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: April 2, 2023
Abstract
Type
2
diabetes
mellitus
(T2DM),
one
of
the
main
types
Noncommunicable
diseases
(NCDs),
is
a
systemic
inflammatory
disease
characterized
by
dysfunctional
pancreatic
β-cells
and/or
peripheral
insulin
resistance,
resulting
in
impaired
glucose
and
lipid
metabolism.
Genetic,
metabolic,
multiple
lifestyle,
sociodemographic
factors
are
known
as
related
to
high
T2DM
risk.
Dietary
lipids
metabolism
significant
metabolic
modulators
T2DM-related
complications.
Besides,
accumulated
evidence
suggests
that
altered
gut
microbiota
which
plays
an
important
role
health
host
contributes
significantly
involving
or
improved
At
this
point,
dietary
may
affect
physiology
via
interaction
with
microbiota.
increasing
literature
lipidomics
novel
parameters
detected
holistic
analytical
techniques
have
roles
pathogenesis
progression
T2DM,
through
various
mechanisms
action
including
gut-brain
axis
modulation.
A
better
understanding
some
nutrients
interactions
will
help
develop
new
strategies
for
prevention
treatment
T2DM.
However,
issue
has
not
yet
been
entirely
discussed
literature.
The
present
review
provides
up-to-date
knowledge
on
nutritional
considering
lipids-
given.
Scientific Reports,
Journal Year:
2020,
Volume and Issue:
10(1)
Published: July 16, 2020
Abstract
Probiotics
have
been
reported
to
a
positive
impact
on
the
metabolic
control
of
patients
with
type
2
diabetes.
We
aimed
systematically
evaluate
effects
probiotics
cardiometabolic
parameters
in
diabetes
based
randomized
controlled
studies.
MEDLINE,
Embase,
and
CENTRAL
databases
were
reviewed
search
for
trials
that
examined
probiotic
supplementation
32
provided
results
suitable
be
included
analysis.
The
calculated
following
parameters:
BMI,
total
cholesterol
levels,
LDL,
triglycerides,
HDL,
CRP,
HbA1c
fasting
plasma
glucose,
insulin
systolic
diastolic
blood
pressure
values.
Data
analysis
showed
significant
effect
reducing
cholesterol,
triglyceride
HbA1c,
both
Supplementation
increased
HDL
levels
however
did
not
BMI
or
LDL
levels.
Our
data
clearly
suggest
could
supplementary
therapeutic
approach
mellitus
improve
dyslipidemia
promote
better
control.
According
our
analysis,
is
beneficial
mellitus.
