Diabetes and restenosis

Cardiovascular Diabetology, Journal Year: 2022, Volume and Issue: 21(1)

Published: Feb. 14, 2022

Restenosis, defined as the re-narrowing of an arterial lumen after revascularization, represents increasingly important issue in clinical practice. Indeed, number stent placements has risen to estimate that exceeds 3 million annually worldwide, revascularization procedures have become much more common. Several investigators demonstrated vessels patients with diabetes mellitus increased risk restenosis. Here we present a systematic overview effects on in-stent Current classification and updated epidemiology restenosis are discussed, alongside main mechanisms underlying pathophysiology this event. Then, summarize presentation restenosis, emphasizing importance glycemic control diabetic patients. who underwent proper remains imperative.

Language: Английский

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Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications

Theranostics, Journal Year: 2022, Volume and Issue: 12(3), P. 1342 - 1372

Published: Jan. 1, 2022

Diabetes mellitus (DM) is a chronic systemic disease with increasing prevalence globally.An important aspect of diabetic pathogenesis cellular crosstalk and information exchange between multiple metabolic organs tissues.In the past decade, evidence suggested that extracellular vesicles (EVs), class cell-derived membrane transmit perform inter-cellular inter-organ communication, are involved in pathological changes insulin resistance (IR), inflammation, endothelial injury, implicated development DM its complications.The biogenesis cargo sorting machinery dysregulation EVs may mediate their pathogenic roles under conditions.Moreover, EVs, ubiquitous production by different cells, function as mediators biological features body fluids have generated great promise biomarkers clinical treatments.In this review, we summarize components EV generation highlight role associated complications.Furthermore, discuss emerging implications potential therapeutic strategies for complications.A better understanding will deepen our knowledge pathophysiology complications offer attractive approaches to improve prevention, diagnosis, treatment, prognosis these disorders.

Language: Английский

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Intensified glycemic control by HbA1c for patients with coronary heart disease and Type 2 diabetes: a review of findings and conclusions

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: June 22, 2023

Abstract The occurrence and development of coronary heart disease (CHD) are closely linked to fluctuations in blood glucose levels. While the efficacy intensified treatment guided by HbA1c levels remains uncertain for individuals with diabetes CHD, this review summarizes findings conclusions regarding context CHD. Our showed a curvilinear correlation between regulated level therapeutic effectiveness glycemic control among patients type 2 disease. It is necessary optimize dynamic monitoring indicators HbA1c, combine genetic profiles, haptoglobin phenotypes example select more suitable hypoglycemic drugs establish appropriate glucose-controlling guideline CHD at different stage diabetes.

Language: Английский

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A Narrative Review of Diabetic Macroangiopathy: From Molecular Mechanism to Therapeutic Approaches

Diabetes Therapy, Journal Year: 2024, Volume and Issue: 15(3), P. 585 - 609

Published: Feb. 2, 2024

Diabetic macroangiopathy, a prevalent and severe complication of diabetes mellitus, significantly contributes to the increased morbidity mortality rates among affected individuals. This complex disorder involves multifaceted molecular mechanisms that lead dysfunction damage large blood vessels, including atherosclerosis (AS) peripheral arterial disease. Understanding intricate pathways underlying development progression diabetic macroangiopathy is crucial for effective therapeutic interventions. review aims shed light on mechanism implicated in pathogenesis macroangiopathy. We delve into interplay chronic inflammation, oxidative stress, endothelial dysfunction, dysregulated angiogenesis, all which contribute vascular complications observed this disorder. By exploring involved disease we provide insight potential targets strategies. Moreover, discuss current approaches used treating glycemic control, lipid-lowering agents,

Language: Английский

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Intermittent Use of Flash Glucose Monitoring Improves Glycemic Control in Chinese Older Patients with Type 2 Diabetes Mellitus

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 1 - 9

Published: Jan. 1, 2025

Objective: To explore the efficacy and safety of intermittent use flash glucose monitoring (FGM) for improving glycemic control in Chinese elderly patients with type 2 diabetes mellitus (T2DM). Methods: This is a prospective observational study involving T2DM aged ≥ 60 years. The period spans 12 weeks, participants wearing FGM at weeks 0, 5, 10. Participants were divided into two subgroups based on HbA1c enrollment: < 7.0% 7.0%. primary outcome was level. Secondary outcomes included time range (3.9– 10mmol/L) (TIR), below (< 3.9mmol/L) (TBR), above (> 10.0mmol/L) (TAR), variability (GV). Results: A total 68 completed 12-week follow-up (age 67.9 ± 5.2 years; BMI 25.4 3.3kg/m²). Overall findings revealed that compared to baseline, decreased from 7.81 1.25% 7.44± 1.10% after (p 0.001). In subgroup analysis 7.0%, results showed significant reduction 0.51mmol/L (8.36 0.95% vs 7.75 0.97%, p And there TBR 7% = 0.028). Multiple linear regression baseline (β − 0.529, P< 0.001), duration 0.341, P frequency sensor 0.269, 0.043) associated Conclusion: Intermittent an improvement reduces risk hypoglycemia T2DM. Keywords: monitoring, mellitus, HbA1c,

Language: Английский

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Correlation Between Glycemic Variability and Diabetic Complications: A Narrative Review

International Journal of General Medicine, Journal Year: 2023, Volume and Issue: Volume 16, P. 3083 - 3094

Published: July 1, 2023

Abstract: Diabetes mellitus is a metabolic disorder with complex etiology in which glycemic dynamics are disturbed and the body unable to maintain process of glucose homeostasis through pancreas. Persistent symptoms high blood or low may lead diabetic complications, such as neuropathy, nephropathy, retinopathy, cardiovascular diseases. Glycemic variability can represent presence excessive excursions an indicator for evaluating homoeostasis. Limiting has gradually become emerging therapeutic target improve diabetes metabolism prevent associated complications. This article reviews progress research on various quantifiable parameters their relationships vascular lesions mechanisms. Keywords: mellitus, variability, parameters,

Language: Английский

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Understanding the role of hyperglycemia and the molecular mechanism associated with diabetic neuropathy and possible therapeutic strategies

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 215, P. 115723 - 115723

Published: Aug. 1, 2023

Language: Английский

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Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: March 4, 2024

Type 2 diabetes mellitus (T2DM) poses a significant global health burden. This is particularly due to its macrovascular complications, such as coronary artery disease, peripheral vascular and cerebrovascular which have emerged leading contributors morbidity mortality. review comprehensively explores the pathophysiological mechanisms underlying these protective strategies, both existing emerging secondary preventive measures. Furthermore, we delve into applications of experimental models methodologies in foundational research while also highlighting current limitations future directions. Specifically, focus on literature published post-2020 concerning prevention complications patients with T2DM by conducting targeted studies supported robust evidence offer holistic perspective.

Language: Английский

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Sustained Release of Hydrogen and Magnesium Ions Mediated by a Foamed Gelatin-Methacryloyl Hydrogel for the Repair of Bone Defects in Diabetes

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(7), P. 4411 - 4424

Published: June 24, 2024

Diabetic bone defects, exacerbated by hyperglycemia-induced inflammation and oxidative stress, present significant therapeutic challenges. This study introduces a novel injectable scaffold, MgH2@PLGA/F-GM, consisting of foamed gelatin-methacryloyl (GelMA) magnesium hydride (MgH2) microspheres encapsulated in poly(lactic-co-glycolic acid) (PLGA). scaffold is uniquely suited for diabetic conforming to complex shapes fostering an environment conducive tissue regeneration. As it degrades, Mg(OH)2 released dissolved PLGA's acidic byproducts, releasing Mg2+ ions. These ions are instrumental macrophage phenotype modulation, reduction, angiogenesis promotion, all vital healing. Additionally, hydrogen (H2) during degradation mitigates stress diminishing reactive oxygen species (ROS). multifaceted approach not only reduces ROS but also enhances M2 polarization cell migration, culminating improved repair. presents innovative strategy addressing the complexities defect treatment.

Language: Английский

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Comparative Effect of Glucose-Lowering Drugs for Type 2 Diabetes Mellitus on Stroke Prevention: A Systematic Review and Network Meta-Analysis

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(2), P. 312 - 320

Published: Jan. 26, 2024

Background: There is still a lack of research on which diabetic drugs are more effective in preventing stroke. Our network metaanalysis aimed to compare cerebrovascular benefits among glucose-lowering treatments.Methods: We searched MEDLINE, EMBASE, the Cochrane Central Register Controlled Trials, and ClinicalTrials.gov registry for clinical trials from inception through May 25, 2021. included both prespecified outcomes events reported as severe adverse events. Subgroup analyses were conducted by stroke subtype, publication type, age patients, baseline glycosylated hemoglobin (HbA1c), duration type 2 diabetes mellitus, cardiovascular risks.Results: Of 2,861 reports 1,779 screened, 79 randomized controlled comprising 206,387 patients fulfilled inclusion criteria. In pairwise meta-analysis, use glucagon-like peptide-1 (GLP-1) agonist was associated with lower risk total compared placebo (relative [RR], –0.17; 95% confidence interval [CI], –0.27 –0.07). meta- analysis, only sodium-glucose cotransporter-2 (SGLT-2) inhibitor reduction stroke, (RR, 0.81; CI, 0.67 0.98). subgroup analyses, SGLT-2 GLP-1 those high HbA1c (≥8.0) low-risk disease, respectively.Conclusion: inhibitors agonists shown be beneficial prevention mellitus.

Language: Английский

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